Dietary Oxidative Balance Scores and Biomarkers of Inflammation among Individuals with and without Chronic Kidney Disease
Conclusion: This study suggests that a higher OBS is associated with more favorable levels of IL-6 and CRP, and that the association of OBS and IL-6 may be modified by CKD status.Nephron Extra 2018;8:11 –23 (Source: Nephron Extra)
Source: Nephron Extra - August 21, 2018 Category: Urology & Nephrology Source Type: research

Proteinuria and the Clinical Course of Dobrava-Belgrade Hantavirus Infection
Conclusions: DOBV infection of inpatients in Northern Germany is associated with severe kidney injury that recovers within a few weeks and normalizes within 1 year. Tubular proteinuria is associated with the severity of kidney injury and the necessity of renal replacement therapy in these DOBV-infected patients.Nephron Extra 2018;8:1 –10 (Source: Nephron Extra)
Source: Nephron Extra - February 9, 2018 Category: Urology & Nephrology Source Type: research

Evaluation of the Relationship between the Serum Alkaline Phosphatase Level at Dialysis Initiation and All-Cause Mortality: A Multicenter, Prospective Study
Conclusion: The serum ALP level at dialysis initiation is associated with all-cause mortality during maintenance dialysis.Nephron Extra 2017;7:78 –88 (Source: Nephron Extra)
Source: Nephron Extra - November 28, 2017 Category: Urology & Nephrology Source Type: research

Renal Effects and Carcinogenicity of Occupational Exposure to Uranium: A Meta-Analysis
Conclusion: Our hypothesis that a chronic uranium exposure is associated with an increased risk of cancer mortality or of kidney failure is refuted by clinical data. The decreased risk may result from better medical surveillance of uranium workers.Nephron Extra 2016;6:1-11 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

The Impact of Baseline Serum Creatinine on Complete Remission Rate and Long-Term Outcome in Patients with Severe Lupus Nephritis
Background/Aim: We assess the impact of serum creatinine at baseline on complete remission rate and long-term outcome in severe lupus nephritis (SLN).Methods: A total of 86 adult patients with SLN [International Society of Nephrology/Renal Pathology Society (ISN/RPS) class IV lesions] were evaluated based on baseline serum creatinine levels ( ≤1.0, 1.01-1.5, 1.51-2.0, 2.01-3.0, and>3.0 mg/dl; n = 22, 23, 16, 12, and 13, respectively). The complete remission rates (serum creatinine level of ≤1.4 mg/dl and proteinuria of ≤0.33 g/day) and long-term outcomes (stable renal function, dialysis, and death) were compared. The...
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

New Insight into Atherosclerosis in Hemodialysis Patients: Overexpression of Scavenger Receptor and Macrophage Colony-Stimulating Factor Genes
Background: Scavenger receptors (SRs) play a pivotal role in atherogenesis. The mechanism of atherosclerosis, which is specific to hemodialysis (HD) patients, was studied on the basis of SR gene expressions.Methods: The gene expressions of SR type A (SR-A) and CD36 were studied in peripheral monocytes by real-time reverse transcription polymerase chain reaction. Data were compared between HD (n = 30) and age-matched control subjects (n = 10). Serum levels of macrophage colony-stimulating factor (M-CSF) were measured with enzyme-linked immunosorbent assay to test its role in SR expression. The statistical differences and as...
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

Immunohistochemical Glomerular Expression of Phospholipase A2 Receptor in Primary and Secondary Membranous Nephropathy: A Retrospective Study in an Indian Cohort with Clinicopathological Correlations 

Conclusion: Anti-PLA2R IHC is a specific marker to distinguish primary MN from secondary MN. 
Nephron Extra 2017;7:1 –9 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

The Dialysis Sodium Gradient: A Modifiable Risk Factor for Fluid Overload 

Conclusion: A higher sodium gradient was associated with significant increases in IDWG and UF rates, known to be associated with poor outcomes, but was not associated with intradialytic hypotension. Individualizing the dialysate sodium prescription to minimize sodium gap may lead to less fluid overload in conventional hemodialysis patients. 
Nephron Extra 2017;7:10 –17 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

Improving CKD Diagnosis and Blood Pressure Control in Primary Care: A Tailored Multifaceted Quality Improvement Programme
Conclusions: Participating practices identified large numbers of “missing” CKD patients with comparator data showing they outperformed non-QI practices locally and nationally over similar timeframes. Improved BP control also occurred through this intervention, but overall achievement of the tighter BP target in proteinuric patients was notably less.Nephron Extra 2017;7:18 –32 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

MicroRNA-155 and Anti-M üllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease

Conclusions: We conclude that men with stage 3 –4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1–4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and A MH may be potential markers of subfertility in men with CKD.
Nephron Extra 2017;7:33 –41 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

Changes in Cerebral Oxygenation Associated with Intradialytic Blood Transfusion in Patients with Severe Anemia Undergoing Hemodialysis
Conclusion: HD patients with severe anemia represented cerebral oxygen metabolism deterioration, which could be significantly improved by intradialytic blood transfusion.Nephron Extra 2017;7:42 –51 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia
Conclusions: IgAN presents elevated uCD80 excretion and uPAR-positive podocyturia, while CD80 correlates with podocyturia. Glomerulosclerosis (S1) at the time of biopsy is associated with higher uP/C, lower renal function, increased uPAR-positive podocyturia, and CD80 excretion, and is independent of M1. In IgAN, uPAR may participate in podocyte detachment.Nephron Extra 2017;7:52 –61 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research