Dietary Oxidative Balance Scores and Biomarkers of Inflammation among Individuals with and without Chronic Kidney Disease
Conclusion: This study suggests that a higher OBS is associated with more favorable levels of IL-6 and CRP, and that the association of OBS and IL-6 may be modified by CKD status.Nephron Extra 2018;8:11 –23 (Source: Nephron Extra)
Source: Nephron Extra - August 21, 2018 Category: Urology & Nephrology Source Type: research

Proteinuria and the Clinical Course of Dobrava-Belgrade Hantavirus Infection
Conclusions: DOBV infection of inpatients in Northern Germany is associated with severe kidney injury that recovers within a few weeks and normalizes within 1 year. Tubular proteinuria is associated with the severity of kidney injury and the necessity of renal replacement therapy in these DOBV-infected patients.Nephron Extra 2018;8:1 –10 (Source: Nephron Extra)
Source: Nephron Extra - February 9, 2018 Category: Urology & Nephrology Source Type: research

Evaluation of the Relationship between the Serum Alkaline Phosphatase Level at Dialysis Initiation and All-Cause Mortality: A Multicenter, Prospective Study
Conclusion: The serum ALP level at dialysis initiation is associated with all-cause mortality during maintenance dialysis.Nephron Extra 2017;7:78 –88 (Source: Nephron Extra)
Source: Nephron Extra - November 28, 2017 Category: Urology & Nephrology Source Type: research

Renal Effects and Carcinogenicity of Occupational Exposure to Uranium: A Meta-Analysis
Conclusion: Our hypothesis that a chronic uranium exposure is associated with an increased risk of cancer mortality or of kidney failure is refuted by clinical data. The decreased risk may result from better medical surveillance of uranium workers.Nephron Extra 2016;6:1-11 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

The Impact of Baseline Serum Creatinine on Complete Remission Rate and Long-Term Outcome in Patients with Severe Lupus Nephritis
Background/Aim: We assess the impact of serum creatinine at baseline on complete remission rate and long-term outcome in severe lupus nephritis (SLN).Methods: A total of 86 adult patients with SLN [International Society of Nephrology/Renal Pathology Society (ISN/RPS) class IV lesions] were evaluated based on baseline serum creatinine levels ( ≤1.0, 1.01-1.5, 1.51-2.0, 2.01-3.0, and>3.0 mg/dl; n = 22, 23, 16, 12, and 13, respectively). The complete remission rates (serum creatinine level of ≤1.4 mg/dl and proteinuria of ≤0.33 g/day) and long-term outcomes (stable renal function, dialysis, and death) were compare...
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

New Insight into Atherosclerosis in Hemodialysis Patients: Overexpression of Scavenger Receptor and Macrophage Colony-Stimulating Factor Genes
Background: Scavenger receptors (SRs) play a pivotal role in atherogenesis. The mechanism of atherosclerosis, which is specific to hemodialysis (HD) patients, was studied on the basis of SR gene expressions.Methods: The gene expressions of SR type A (SR-A) and CD36 were studied in peripheral monocytes by real-time reverse transcription polymerase chain reaction. Data were compared between HD (n = 30) and age-matched control subjects (n = 10). Serum levels of macrophage colony-stimulating factor (M-CSF) were measured with enzyme-linked immunosorbent assay to test its role in SR expression. The statistical differences and as...
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

Immunohistochemical Glomerular Expression of Phospholipase A2 Receptor in Primary and Secondary Membranous Nephropathy: A Retrospective Study in an Indian Cohort with Clinicopathological Correlations 

Conclusion: Anti-PLA2R IHC is a specific marker to distinguish primary MN from secondary MN. 
Nephron Extra 2017;7:1 –9 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

The Dialysis Sodium Gradient: A Modifiable Risk Factor for Fluid Overload 

Conclusion: A higher sodium gradient was associated with significant increases in IDWG and UF rates, known to be associated with poor outcomes, but was not associated with intradialytic hypotension. Individualizing the dialysate sodium prescription to minimize sodium gap may lead to less fluid overload in conventional hemodialysis patients. 
Nephron Extra 2017;7:10 –17 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

Improving CKD Diagnosis and Blood Pressure Control in Primary Care: A Tailored Multifaceted Quality Improvement Programme
Conclusions: Participating practices identified large numbers of “missing” CKD patients with comparator data showing they outperformed non-QI practices locally and nationally over similar timeframes. Improved BP control also occurred through this intervention, but overall achievement of the tighter BP target in proteinuric patients was notably less.Nephron Extra 2017;7:18 –32 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

MicroRNA-155 and Anti-M üllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease

Conclusions: We conclude that men with stage 3 –4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1–4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and A MH may be potential markers of subfertility in men with CKD.
Nephron Extra 2017;7:33 –41 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

Changes in Cerebral Oxygenation Associated with Intradialytic Blood Transfusion in Patients with Severe Anemia Undergoing Hemodialysis
Conclusion: HD patients with severe anemia represented cerebral oxygen metabolism deterioration, which could be significantly improved by intradialytic blood transfusion.Nephron Extra 2017;7:42 –51 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia
Conclusions: IgAN presents elevated uCD80 excretion and uPAR-positive podocyturia, while CD80 correlates with podocyturia. Glomerulosclerosis (S1) at the time of biopsy is associated with higher uP/C, lower renal function, increased uPAR-positive podocyturia, and CD80 excretion, and is independent of M1. In IgAN, uPAR may participate in podocyte detachment.Nephron Extra 2017;7:52 –61 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

Urinary Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Acute Kidney Injury, Severe Kidney Injury, and the Need for Renal Replacement Therapy in the Intensive Care Unit
Conclusions: Maximum urine levels of uNGAL measured over the first and second 24 h of an ICU admission were highly accurate predictors of the future need for RRT, however less accurate at detecting early and severe AKI.Nephron Extra 2017;7:62 –77 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research

In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia
Conclusions: IgAN presents elevated uCD80 excretion and uPAR-positive podocyturia, while CD80 correlates with podocyturia. Glomerulosclerosis (S1) at the time of biopsy is associated with higher uP/C, lower renal function, increased uPAR-positive podocyturia, and CD80 excretion, and is independent of M1. In IgAN, uPAR may participate in podocyte detachment.Nephron Extra 2017;7:52 –61 (Source: Nephron Extra)
Source: Nephron Extra - May 16, 2017 Category: Urology & Nephrology Source Type: research

Changes in Cerebral Oxygenation Associated with Intradialytic Blood Transfusion in Patients with Severe Anemia Undergoing Hemodialysis
Conclusion: HD patients with severe anemia represented cerebral oxygen metabolism deterioration, which could be significantly improved by intradialytic blood transfusion.Nephron Extra 2017;7:42 –51 (Source: Nephron Extra)
Source: Nephron Extra - April 28, 2017 Category: Urology & Nephrology Source Type: research

Improving CKD Diagnosis and Blood Pressure Control in Primary Care: A Tailored Multifaceted Quality Improvement Programme
Conclusions: Participating practices identified large numbers of “missing” CKD patients with comparator data showing they outperformed non-QI practices locally and nationally over similar timeframes. Improved BP control also occurred through this intervention, but overall achievement of the tighter BP target in proteinuric patients was notably less.Nephron Extra 2017;7:18 –32 (Source: Nephron Extra)
Source: Nephron Extra - April 11, 2017 Category: Urology & Nephrology Source Type: research

MicroRNA-155 and Anti-M üllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease

Conclusions: We conclude that men with stage 3 –4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1–4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and A MH may be potential markers of subfertility in men with CKD.
Nephron Extra 2017;7:33 –41 (Source: Nephron Extra)
Source: Nephron Extra - April 11, 2017 Category: Urology & Nephrology Source Type: research

Immunohistochemical Glomerular Expression of Phospholipase A2 Receptor in Primary and Secondary Membranous Nephropathy: A Retrospective Study in an Indian Cohort with Clinicopathological Correlations 

Conclusion: Anti-PLA2R IHC is a specific marker to distinguish primary MN from secondary MN. 
Nephron Extra 2017;7:1 –9 (Source: Nephron Extra)
Source: Nephron Extra - February 9, 2017 Category: Urology & Nephrology Source Type: research

The Dialysis Sodium Gradient: A Modifiable Risk Factor for Fluid Overload 

Conclusion: A higher sodium gradient was associated with significant increases in IDWG and UF rates, known to be associated with poor outcomes, but was not associated with intradialytic hypotension. Individualizing the dialysate sodium prescription to minimize sodium gap may lead to less fluid overload in conventional hemodialysis patients. 
Nephron Extra 2017;7:10 –17 (Source: Nephron Extra)
Source: Nephron Extra - February 9, 2017 Category: Urology & Nephrology Source Type: research

Neutrophil Gelatinase-Associated Lipocalin, Fibroblast Growth Factor 23, and Soluble Klotho in Long-Term Kidney Donors
Background: The best treatment for end-stage renal disease (ESRD) is kidney transplantation. Twenty-seven percent of transplantations in Norway are from living donors. Recent studies have shown an increased risk of ESRD and increased mortality in donors. The aim of this study was to determine if the levels of the new biomarkers neutrophil gelatinase-associated lipocalin (NGAL), soluble Klotho (sKlotho), and fibroblast growth factor 23 (FGF23) are changed in kidney donors with normal kidney function defined as an estimated glomerular filtration rate (eGFR)>60 ml/min/1.73 m2 compared to patients with chronic kidney diseas...
Source: Nephron Extra - October 11, 2016 Category: Urology & Nephrology Source Type: research

New Insight into Atherosclerosis in Hemodialysis Patients: Overexpression of Scavenger Receptor and Macrophage Colony-Stimulating Factor Genes
Background: Scavenger receptors (SRs) play a pivotal role in atherogenesis. The mechanism of atherosclerosis, which is specific to hemodialysis (HD) patients, was studied on the basis of SR gene expressions.Methods: The gene expressions of SR type A (SR-A) and CD36 were studied in peripheral monocytes by real-time reverse transcription polymerase chain reaction. Data were compared between HD (n = 30) and age-matched control subjects (n = 10). Serum levels of macrophage colony-stimulating factor (M-CSF) were measured with enzyme-linked immunosorbent assay to test its role in SR expression. The statistical differences and as...
Source: Nephron Extra - August 26, 2016 Category: Urology & Nephrology Source Type: research

The Impact of Baseline Serum Creatinine on Complete Remission Rate and Long-Term Outcome in Patients with Severe Lupus Nephritis
Background/Aim: We assess the impact of serum creatinine at baseline on complete remission rate and long-term outcome in severe lupus nephritis (SLN).Methods: A total of 86 adult patients with SLN [International Society of Nephrology/Renal Pathology Society (ISN/RPS) class IV lesions] were evaluated based on baseline serum creatinine levels ( ≤1.0, 1.01-1.5, 1.51-2.0, 2.01-3.0, and>3.0 mg/dl; n = 22, 23, 16, 12, and 13, respectively). The complete remission rates (serum creatinine level of ≤1.4 mg/dl and proteinuria of ≤0.33 g/day) and long-term outcomes (stable renal function, dialysis, and death) were compare...
Source: Nephron Extra - August 17, 2016 Category: Urology & Nephrology Source Type: research

Effects of Tumor Necrosis Factor- α on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy
Conclusion: TNF- α potently stimulates podocytes to produce MCP-1, utilizing the TNFR2 receptor and the NF-#954;B and PI3K/Akt pathways. Both TNF-α and MCP-1 levels were increased in the urine of diabetic db/db mice, correlating with the severity of diabetic albuminuria. Nephron Extra 2015;5:1-18 (Source: Nephron Extra)
Source: Nephron Extra - July 22, 2016 Category: Urology & Nephrology Source Type: research

Renal Effects and Carcinogenicity of Occupational Exposure to Uranium: A Meta-Analysis
Conclusion: Our hypothesis that a chronic uranium exposure is associated with an increased risk of cancer mortality or of kidney failure is refuted by clinical data. The decreased risk may result from better medical surveillance of uranium workers.Nephron Extra 2016;6:1-11 (Source: Nephron Extra)
Source: Nephron Extra - February 10, 2016 Category: Urology & Nephrology Source Type: research

A Higher Cardiothoracic Ratio Is Associated with 2-Year Mortality after Hemodialysis Initiation
A high cardiothoracic ratio (CTR) is indicative of a cardiac disorder. However, few reports have revealed an association between the CTR and mortality in patients starting hemodialysis (HD). Methods: Patients with HD initiation (n = 387; mean age, 66.7 ± 12.7 years) were divided into the following three groups according to their CTR at HD initiation: CTR 55% may improve their survival.Nephron Extra 2015;5:100-110 (Source: Nephron Extra)
Source: Nephron Extra - December 19, 2015 Category: Urology & Nephrology Source Type: research

Prehospitalization Risk Factors for Acute Kidney Injury during Hospitalization for Serious Infections in the REGARDS Cohort
In this study, we determined prehospitalization characteristics associated with AKI in community-dwelling adults hospitalized for a serious infection. Methods: We used prospective data from 30,239 participants of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a national cohort of community-dwelling adults ≥45 years old. We identified serious infection hospitalizations between 2003 and 2012. Using the Kidney Disease Improving Global Outcomes (KDIGO) criteria, we defined AKI as an increase in serum creatinine (sCr) ≥0.3 mg/dl from the first inpatient sCr measurement during the first 7 hosp...
Source: Nephron Extra - November 10, 2015 Category: Urology & Nephrology Source Type: research

Factors Contributing to Erythropoietin Hyporesponsiveness in Patients on Long-Term Continuous Ambulatory Peritoneal Dialysis: A Cross-Sectional Study
We examined associations between ERI and clinical parameters, such as physiological, chemical and nutrition status, by correlation and multiple linear regression analyses. Results: Peritoneal dialysis duration was 95 ± 23 months, and all patients underwent peritoneal dialysis for>5 years. Hemoglobin, blood pressure and ultrafiltration volume of peritoneal dialysis were 11.5 ± 1.2 g/dl, 123 ± 14/72 ± 8 mm Hg and 834 ± 317 ml/day, respectively. Renal Kt/V and peritoneal Kt/V, which are indices of dialysis adequacy, were 0.32 ± 0.31 and 1.70 ± 0.31, respectively. Age and ext...
Source: Nephron Extra - October 29, 2015 Category: Urology & Nephrology Source Type: research

Vasoactive Peptide Levels after Change of Dialysis Mode
Conclusion: The postdialysis plasma levels of NT-proBNP, BNP and NPY decreased significantly during both dialysis modes when compared to before dialysis. The postdialysis lowering of NT-proBNP increased further over time after the switch to ol-HDF; the predialysis levels were unchanged, suggesting no effect on its production in the ventricles of the heart.Nephron Extra 2015;5:67-78 (Source: Nephron Extra)
Source: Nephron Extra - October 29, 2015 Category: Urology & Nephrology Source Type: research

Approximation of Corrected Calcium Concentrations in Advanced Chronic Kidney Disease Patients with or without Dialysis Therapy
Conclusion: Compared to other formulas, the approximated corrected TCa values calculated from the new formula for patients with CKD G4 + G5 and CKD G5D demonstrates superior agreement with the measured corrected TCa.Nephron Extra 2015;5:39-49 (Source: Nephron Extra)
Source: Nephron Extra - September 2, 2015 Category: Urology & Nephrology Source Type: research

Thrice-Weekly Nocturnal In-Centre Haemodiafiltration: A 2-Year Experience
Background: Adequate control of plasma phosphate without phosphate binders is difficult to achieve on a thrice-weekly haemodialysis schedule. The use of quotidian nocturnal dialysis is effective but not practical in the in-centre setting. This quality improvement project was set up as an exercise allowing the evaluation of small-solute clearance by combining convection with extended-hour dialysis in a thrice-weekly hospital setting. Methods: A single-centred, prospective analysis of patients' electronic records was performed from August 2012 to July 2014. The duration of haemodiafiltration was increased from a median of 4....
Source: Nephron Extra - August 29, 2015 Category: Urology & Nephrology Source Type: research

A Prospective Observational Survey on the Long-Term Effect of LDL Apheresis on Drug-Resistant Nephrotic Syndrome
Background/Aims: LDL apheresis (LDL-A) is used for drug-resistant nephrotic syndrome (NS) as an alternative therapy to induce remission by improvement of hyperlipidemia. Several clinical studies have suggested the efficacy of LDL-A for refractory NS, but the level of evidence remains insufficient. A multicenter prospective study, POLARIS (Prospective Observational Survey on the Long-Term Effects of LDL Apheresis on Drug-Resistant Nephrotic Syndrome), was conducted to evaluate its clinical efficacy with high-level evidence. Methods: Patients with NS who showed resistance to primary medication for at least 4 weeks were prosp...
Source: Nephron Extra - August 29, 2015 Category: Urology & Nephrology Source Type: research

A Case of Fibrillary Glomerulonephritis Associated with Thrombotic Microangiopathy and Anti-Glomerular Basement Membrane Antibody
In conclusion, it was shown that TMA, FGN and anti-GBM antibody were closely related.Nephron Extra 2015;5:30-38 (Source: Nephron Extra)
Source: Nephron Extra - February 26, 2015 Category: Urology & Nephrology Source Type: research

Lipid Levels and Renal Function Decline in Pre-Dialysis Patients
Background: Little is known about the effect of low-density lipoprotein (LDL) cholesterol, triglyceride (TG), and high-density lipoprotein (HDL) cholesterol levels on renal function decline in patients receiving specialized pre-dialysis care. Methods: In the prospective PREPARE-2 study, incident patients starting pre-dialysis care were included when referred to one of the 25 participating Dutch specialized pre-dialysis outpatient clinics (2004-2011). Clinical and laboratory data were collected every 6 months. A linear mixed model was used to compare renal function decline between patients with LDL cholesterol, TG, or HDL c...
Source: Nephron Extra - February 3, 2015 Category: Urology & Nephrology Source Type: research

Effects of Tumor Necrosis Factor-α on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy
Conclusion: TNF-α potently stimulates podocytes to produce MCP-1, utilizing the TNFR2 receptor and the NF-#x03BA;B and PI3K/Akt pathways. Both TNF-α and MCP-1 levels were increased in the urine of diabetic db/db mice, correlating with the severity of diabetic albuminuria.Nephron Extra 2015;5:1-18 (Source: Nephron Extra)
Source: Nephron Extra - February 3, 2015 Category: Urology & Nephrology Source Type: research

The Effect of Shiga Toxin on Weibel-Palade Bodies in Primary Human Endothelial Cells
Conclusion: Stx1 can contribute, via an effect on WPbs, to the exocytosis of WPbs in flow conditions in HUVECs and probably in GMVECs. This results in the release of VWF, suggesting an initiating role of the coagulation system in the pathogenesis.Nephron Extra 2014;4:101-107 (Source: Nephron Extra)
Source: Nephron Extra - November 7, 2014 Category: Urology & Nephrology Source Type: research

Improvements in Renal Replacement Therapy Practice Patterns in Estonia
Conclusion: An improvement in the data collection was noticed, and the analysis of CPI allows renal centres to assess and compare their practices with others. The collection and evaluation of CPI of RRT patients is an important improvement and significantly increases the awareness of nephrologists.Nephron Extra 2014;4:108-118 (Source: Nephron Extra)
Source: Nephron Extra - November 7, 2014 Category: Urology & Nephrology Source Type: research

Renal AA Amyloidosis in Patients with Type 2 Diabetes Mellitus
Conclusions: RAAA is prevalent in T2DM and is associated with worse CVD and renal disease, likely because RAAA is a marker of severe chronic inflammation.Nephron Extra 2014;4:119-126 (Source: Nephron Extra)
Source: Nephron Extra - November 7, 2014 Category: Urology & Nephrology Source Type: research

Urinary Alpha- and Pi-Glutathione S-Transferases in Adult Patients with Type 1 Diabetes
Background/Aims: Glutathione S-transferases (GSTs) are cytosolic enzymes excreted from renal tubules following tubular damage. α-GST primarily originates from proximal tubules, while π-GST from distal tubules and collecting ducts. We investigated if GST levels are associated with renal function in patients with type 1 diabetes. Methods: We conducted a cross-sectional study including 189 Caucasian patients with type 1 diabetes and 16 nondiabetic controls. α- and π-GST were measured by ELISA and reported as GST/urinary creatinine excretion (μg/mmol). Results: The subjects were 53 ± 14 years old, 6...
Source: Nephron Extra - November 7, 2014 Category: Urology & Nephrology Source Type: research

Metabolic Syndrome in IgA Glomerulonephritis
Conclusion: The number of subjects with MetS among IgAGN patients and the general population is equal in Finland. MetS does not seem to be an independent prognostic variable.Nephron Extra 2014;4:138-145 (Source: Nephron Extra)
Source: Nephron Extra - November 7, 2014 Category: Urology & Nephrology Source Type: research

Safe and Effective Use of Chronic Transdermal Estradiol for Life-Threatening Uremic Bleeding in a Patient with Coronary Artery Disease
We present a patient on long-term peritoneal dialysis with coronary disease who developed recurrent life-threatening bleeding episodes secondary to uremia, where treatment with transdermal estrogen was used safely and effectively for a 24-month period.Nephron Extra 2014;4:134-137 (Source: Nephron Extra)
Source: Nephron Extra - November 7, 2014 Category: Urology & Nephrology Source Type: research

Neph1 Is Reduced in Primary Focal Segmental Glomerulosclerosis, Minimal Change Nephrotic Syndrome, and Corresponding Experimental Animal Models of Adriamycin-Induced Nephropathy and Puromycin Aminonucleoside Nephrosis
Conclusion: With nephrin (but not Neph1) unchanged in FSGS, there might be a disruption of the complex and an involvement of Neph1 in its pathogenesis.Nephron Extra 2014;4:146-154 (Source: Nephron Extra)
Source: Nephron Extra - November 7, 2014 Category: Urology & Nephrology Source Type: research

Conservative Management of an Iatrogenic Arteriovenous Fistula
Conclusion: Our study highlights the etiology of this uncommon complication as well as suggesting a role for conservative management.Nephron Extra 2014;4:155-158 (Source: Nephron Extra)
Source: Nephron Extra - November 7, 2014 Category: Urology & Nephrology Source Type: research

Collapsing Focal Segmental Glomerulosclerosis Resulting from a Single Dose of Zoledronate
We describe the case of a 36-year-old African American female with metastatic breast cancer who presented with nephrotic-range proteinuria and acute kidney injury within 2 weeks of exposure to a single dose of zoledronate. The patient had a partial recovery of her renal function and showed improved proteinuria to a subnephrotic level after discontinuing zoledronate. In contrast to 2 prior reports of zoledronate-induced collapsing FSGS, the causative role of the exposure described here is certain. Our case necessitates the addition of zoledronate to the list of known causes of collapsing FSGS. Furthermore, it highlights the...
Source: Nephron Extra - November 7, 2014 Category: Urology & Nephrology Source Type: research

Frequent Hemodialysis Fistula Infectious Complications
Conclusions: The rate of buttonhole-related infections was high among patients on frequent hemodialysis and more than 50 times greater than that among patients on CIHD with the stepladder technique. Most bacteremias were due to S. aureus - with serious consequences. The risks and benefits of buttonhole cannulation require individual consideration with careful monitoring, prophylaxis and management.Nephron Extra 2014;4:159-167 (Source: Nephron Extra)
Source: Nephron Extra - November 7, 2014 Category: Urology & Nephrology Source Type: research