Urinary Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Acute Kidney Injury, Severe Kidney Injury, and the Need for Renal Replacement Therapy in the Intensive Care Unit
Conclusions: Maximum urine levels of uNGAL measured over the first and second 24 h of an ICU admission were highly accurate predictors of the future need for RRT, however less accurate at detecting early and severe AKI.Nephron Extra 2017;7:62 –77 (Source: Nephron Extra)
Source: Nephron Extra - October 25, 2017 Category: Urology & Nephrology Source Type: research
In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia
Conclusions: IgAN presents elevated uCD80 excretion and uPAR-positive podocyturia, while CD80 correlates with podocyturia. Glomerulosclerosis (S1) at the time of biopsy is associated with higher uP/C, lower renal function, increased uPAR-positive podocyturia, and CD80 excretion, and is independent of M1. In IgAN, uPAR may participate in podocyte detachment.Nephron Extra 2017;7:52 –61 (Source: Nephron Extra)
Source: Nephron Extra - May 16, 2017 Category: Urology & Nephrology Source Type: research
Changes in Cerebral Oxygenation Associated with Intradialytic Blood Transfusion in Patients with Severe Anemia Undergoing Hemodialysis
Conclusion: HD patients with severe anemia represented cerebral oxygen metabolism deterioration, which could be significantly improved by intradialytic blood transfusion.Nephron Extra 2017;7:42 –51 (Source: Nephron Extra)
Source: Nephron Extra - April 28, 2017 Category: Urology & Nephrology Source Type: research
Improving CKD Diagnosis and Blood Pressure Control in Primary Care: A Tailored Multifaceted Quality Improvement Programme
Conclusions: Participating practices identified large numbers of “missing” CKD patients with comparator data showing they outperformed non-QI practices locally and nationally over similar timeframes. Improved BP control also occurred through this intervention, but overall achievement of the tighter BP target in proteinuric patients was notably less.Nephron Extra 2017;7:18 –32 (Source: Nephron Extra)
Source: Nephron Extra - April 11, 2017 Category: Urology & Nephrology Source Type: research
MicroRNA-155 and Anti-M üllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease
Conclusions: We conclude that men with stage 3 –4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1–4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and A MH may be potential markers of subfertility in men with CKD.
Nephron Extra 2017;7:33 –41 (Source: Nephron Extra)
Source: Nephron Extra - April 11, 2017 Category: Urology & Nephrology Source Type: research
MicroRNA-155 and Anti-M üllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease
Conclusions: We conclude that men with stage 3 –4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1–4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and A MH may be potential markers of subfertility in men with CKD.Nephron Extra 2017;7:33 –41 (Source: Nephron Extra)
Source: Nephron Extra - April 7, 2017 Category: Urology & Nephrology Source Type: research
Improving CKD Diagnosis and Blood Pressure Control in Primary Care: A Tailored Multifaceted Quality Improvement Programme
Conclusions: Participating practices identified large numbers of “missing” CKD patients with comparator data showing they outperformed non-QI practices locally and nationally over similar timeframes. Improved BP control also occurred through this intervention, but overall achievement of the tighter BP target in proteinuric patients was notably less.Nephron Extra 2017;7:18 –32 (Source: Nephron Extra)
Source: Nephron Extra - April 7, 2017 Category: Urology & Nephrology Source Type: research
Immunohistochemical Glomerular Expression of Phospholipase A2 Receptor in Primary and Secondary Membranous Nephropathy: A Retrospective Study in an Indian Cohort with Clinicopathological Correlations
Conclusion: Anti-PLA2R IHC is a specific marker to distinguish primary MN from secondary MN.
Nephron Extra 2017;7:1 –9 (Source: Nephron Extra)
Source: Nephron Extra - February 9, 2017 Category: Urology & Nephrology Source Type: research
The Dialysis Sodium Gradient: A Modifiable Risk Factor for Fluid Overload
Conclusion: A higher sodium gradient was associated with significant increases in IDWG and UF rates, known to be associated with poor outcomes, but was not associated with intradialytic hypotension. Individualizing the dialysate sodium prescription to minimize sodium gap may lead to less fluid overload in conventional hemodialysis patients.
Nephron Extra 2017;7:10 –17 (Source: Nephron Extra)
Source: Nephron Extra - February 9, 2017 Category: Urology & Nephrology Source Type: research
The Dialysis Sodium Gradient: A Modifiable Risk Factor for Fluid Overload
Conclusion: A higher sodium gradient was associated with significant increases in IDWG and UF rates, known to be associated with poor outcomes, but was not associated with intradialytic hypotension. Individualizing the dialysate sodium prescription to minimize sodium gap may lead to less fluid overload in conventional hemodialysis patients.Nephron Extra 2017;7:10 –17 (Source: Nephron Extra)
Source: Nephron Extra - February 9, 2017 Category: Urology & Nephrology Source Type: research
