Journal of Pharmacy and Pharmaceutical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Remdesivir-induced conduction abnormalities: A molecular model-based explanation
Conclusion: The proposed mechanism of exogenous cardiac A1 receptor activation from bioaccumulation of GS-441524 as a cause of observed cardiac conduction abnormalities with the use of remdesivir in COVID-19 is viable. Further studies are needed to assess causality.PMID:36942295 | PMC:PMC9990623 | DOI:10.3389/jpps.2023.11208 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - March 21, 2023 Category: Drugs & Pharmacology Authors: Ryan Kingsley Christopher Rohlman Ashley Otto Rahul Chaudhary David Phelan Robert Kirchoff Source Type: research

The mechanism of < em > Leonuri Herba < /em > in improving polycystic ovary syndrome was analyzed based on network pharmacology and molecular docking
Conclusion: In summary, this study elucidates the potential effect of Leonuri Herba on PCOS, which is helpful to provide reference for clinical practice. This is also conducive to the secondary development of motherwort and its monomer components, and precision medicine for PCOS.PMID:36942296 | PMC:PMC9990637 | DOI:10.3389/jpps.2023.11234 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - March 21, 2023 Category: Drugs & Pharmacology Authors: Mali Wu Hua Liu Jie Zhang Fangfang Dai Yiping Gong Yanxiang Cheng Source Type: research

Gastrointestinal perforation associated with novel antineoplastic agents: A real-world study based on the FDA Adverse Event Reporting System
Conclusion: The potential risk of GIP associated with several novel antineoplastic agents was identified through data mining, which provided valuable information on the safety risks associated with GIP among these drugs. The potential threat of GIP should be recognized and managed properly when using these novel antineoplastic agents.PMID:36942297 | PMC:PMC9990630 | DOI:10.3389/jpps.2023.11235 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - March 21, 2023 Category: Drugs & Pharmacology Authors: Zicheng Yu Haibin Zhu Hongjun Chen Lifei Zhu Xiaolan Liao Source Type: research

Effects of dual therapy with betamethasone and tetracycline in a NC/Nga mouse model of atopic dermatitis
Conclusion: The present results show that simultaneous topical application of betamethasone and tetracycline synergistically ameliorates AD-like skin lesions in NC/Nga mice. This suggests that dual therapy with betamethasone and tetracycline for AD lesions colonized by S. aureus might be one of the best options for inhibiting the development of both Th1 and Th2 cells and acting on superficially located S. aureus .PMID:36942298 | PMC:PMC9990628 | DOI:10.3389/jpps.2023.11182 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - March 21, 2023 Category: Drugs & Pharmacology Authors: Katsuhiko Matsui Mahoka Kobayashi Mari Nagano Mio Matsuoka Source Type: research

The role of < em > CYP2C9*2 < /em > , < em > CYP2C9*3 < /em > and < em > VKORC1- < /em > 1639 variants on the susceptibility of upper gastrointestinal bleeding: A full case-control study
Conclusion: Our findings suggest an increased risk of UGIB in carriers of the variant allele of rs9923231 and in carriers of the *3 allele associated with doses of NSAIDs greater than 0.5. Hence, the assessment of these variants might reduce the incidence of NSAIDs-related UGIB and contribute to the safety of the NSAIDs user.PMID:36942299 | PMC:PMC9990631 | DOI:10.3389/jpps.2023.11136 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - March 21, 2023 Category: Drugs & Pharmacology Authors: Marcela Forgerini Gustavo Urbano Tales Rubens De Nadai Sabrina Setembre Batah Alexandre Todorovic Fabro Patr ícia De Carvalho Mastroianni Source Type: research