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Clinical observation of dexmedetomidine nasal spray in the treatment of sleep disorders on the first night after undergoing maxillofacial surgery: a single-center double-blind randomized controlled study
Conclusion: The sleep quality of participants on the night after having undergone maxillofacial surgery was safely and effectively improved by 1.0-1.5 μg/kg dexmedetomidine atomized nasal sprays. Notably, only the latter could prolong N3 sleep. Level of Evidence II: Evidence was obtained from at least one properly designed randomized controlled trial.PMID:37854323 | PMC:PMC10579589 | DOI:10.3389/jpps.2023.11699 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - October 19, 2023 Category: Drugs & Pharmacology Authors: Ye Wang Zibin Jin Wenli Xu Keyu Chen Lingxin Wei Dong Yang Xiaoming Deng Shiyi Tong Source Type: research

Integration of real-world evidence from different data sources in health technology assessment
J Pharm Pharm Sci. 2023 Jul 17;26:11460. doi: 10.3389/jpps.2023.11460. eCollection 2023.ABSTRACTReal-world evidence (RWE) is being increasingly used by a wide range of stakeholders involved in the therapeutic product lifecycle but remains underutilized in the health technology assessment (HTA) process. RWE aims to fill the current evidence gaps, reduce the uncertainty around the benefits of medical technologies, and better understand the long-term impact of health technologies in real-world conditions. Despite the minimal use of RWE in some elements of HTA, there has been a larger push to further utilize RWE in the HTA pro...
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 2, 2023 Category: Drugs & Pharmacology Authors: Pooyeh Graili Jason R Guertin Kelvin K W Chan Mina Tadrous Source Type: research