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Effect of Oregon grape root extracts on P-glycoprotein mediated transport in < em > in vitro < /em > cell lines
Conclusion: Our study showed that Oregon grape root extracts modulated P-glycoprotein, thereby may affect the bioavailability of drugs that are substrates of P-glycoprotein.PMID:38304488 | PMC:PMC10830684 | DOI:10.3389/jpps.2023.11927 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - February 2, 2024 Category: Drugs & Pharmacology Authors: Ying Fan Zhu Zhou Lei Zhang Source Type: research

Comparing broad and narrow phenotype algorithms: differences in performance characteristics and immortal time incurred
Conclusion: Attempting to increase the specificity of a health condition algorithm by adding a second code is a potentially valid approach to increase specificity, albeit at the cost of incurring immortal time.PMID:38235322 | PMC:PMC10791821 | DOI:10.3389/jpps.2023.12095 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - January 18, 2024 Category: Drugs & Pharmacology Authors: Joel N Swerdel Mitchell M Conover Source Type: research

Therapeutic update on oral potassium exchange resin use in chronic kidney disease patients: a systematic review of randomized controlled clinical trials
J Pharm Pharm Sci. 2023 Dec 20;26:11892. doi: 10.3389/jpps.2023.11892. eCollection 2023.ABSTRACTHyperkalemia is a common electrolyte disorder in patients with chronic kidney disease (CKD) that increases in prevalence with the decline of glomerular fltration rate (GFR). Another risk of hyperkalemia is the use of renin-angiotensin-aldosterone system inhibitors (RAASi) and/or mineralocorticoid receptor antagonists (MRAs) in managing CKD and proteinuria. The treatment of chronic hyperkalemia is challenging especially for outpatients. Treatment options for hyperkalemia include the potassium exchange resins of which two new pota...
Source: Journal of Pharmacy and Pharmaceutical Sciences - January 4, 2024 Category: Drugs & Pharmacology Authors: Jaclyn Gruver Akram Al-Makki Brian Shepler Source Type: research

Corrigendum: Applications of exhaled breath condensate analysis for drug monitoring and bioequivalence study of inhaled drugs
J Pharm Pharm Sci. 2023 Dec 18;26:12042. doi: 10.3389/jpps.2023.12042. eCollection 2023.ABSTRACT[This corrects the article DOI: 10.18433/jpps33121.].PMID:38164456 | PMC:PMC10758231 | DOI:10.3389/jpps.2023.12042 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: Nastaran Hashemzadeh Elaheh Rahimpour Abolghasem Jouyban Source Type: research

Third-line treatment patterns in HER2-positive metastatic breast cancer: a retrospective analysis of real-world data in Canada
This study presents the first real-world analysis of third-line treatment patterns in HER2-positive metastatic breast cancer (mBC) patients in Canada. The purpose was to assess evolution of clinical practice and identify unmet needs in post-second-line therapy. Retrospective data from medical records of 66 patients who received third-line treatment before 31st October 2018, and data from 56 patients who received third-line treatment after this date, extracted from the Personalize My Treatment (PMT) cancer patient registry, were analyzed. In the first cohort, the study revealed heterogeneity in the third-line setting, with ...
Source: Journal of Pharmacy and Pharmaceutical Sciences - December 28, 2023 Category: Drugs & Pharmacology Authors: Karen Gambaro M élanie Groleau Suzan McNamara Arif Awan Maged Salem Mahmoud Abdelsalam Eve St-Hilaire Fran çois Vincent Julie Carrier Helen MacKay Louise Provencher Dominique Boudreau Zineb Hamilou Fred Saad Cristiano Ferrario Gerald Batist Maud Marques Source Type: research