Clinical observation of dexmedetomidine nasal spray in the treatment of sleep disorders on the first night after undergoing maxillofacial surgery: a single-center double-blind randomized controlled study

Conclusion: The sleep quality of participants on the night after having undergone maxillofacial surgery was safely and effectively improved by 1.0-1.5 μg/kg dexmedetomidine atomized nasal sprays. Notably, only the latter could prolong N3 sleep. Level of Evidence II: Evidence was obtained from at least one properly designed randomized controlled trial.PMID:37854323 | PMC:PMC10579589 | DOI:10.3389/jpps.2023.11699
Source: Journal of Pharmacy and Pharmaceutical Sciences - Category: Drugs & Pharmacology Authors: Source Type: research