Retrospective Cohort Study of Safety Outcomes Associated with Opioid Rotations to Buprenorphine
The objective of this study was to understand the effect buprenorphine rotations have on respiratory risk and other safety outcomes. This was a retrospective observational study evaluating Veterans who underwent an opioid rotation from full-agonist opioids to buprenorphine products or to alternative opioids. The primary endpoint was change in the Risk Index for Overdose or Serious Opioid-induced Respiratory Depression (RIOSORD) score from baseline to six months post-rotation. Median baseline RIOSORD scores were 26.0 and 18.0 in the Buprenorphine Group and the Alternative Opioid Group, respectively. There was no statistical...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 25, 2023 Category: Palliative Care Authors: Neil K Shah Michael W Chandler Anne V Cetto Lisa L Luciani Jacob Painter Danielle Bailey Source Type: research