Potential Drug Interactions in Terminally-Ill Cancer Patients, a Report from the Middle East
This study aims to evaluate the epidemiology of potential drug interactions in terminally-ill cancer patients receiving exclusively supportive care. In this cross-sectional study, during a 6-month follow-up, we considered the medical record of terminally-ill cancer patients referred to palliative care at the cancer center in Isfahan, Iran. Potential drug-drug interactions (DDIs) were assessed by Lexi-Interact ver.1.1 online software. During the study period, 133 terminally-ill cancer patients were recruited. We detected 1678 DDIs with moderate or major severity levels. Among them, 330, 219, 32, 1075, and 51 interactions we...
Source: Journal of Pain and Palliative Care Pharmacotherapy - September 15, 2023 Category: Palliative Care Authors: Hamed Mahzoni Erfan Naghsh Mehran Sharifi Ayda Moghaddas Mahnaz Momenzadeh Azadeh Moghaddas Source Type: research

Effects of Opioids, Steroids, Benzodiazepines, Anticholinergics, and Antihistamines on the Efficacy of Antipsychotics for Treating Delirium in End-of-Life Adult Patients Undergoing Palliative Care
J Pain Palliat Care Pharmacother. 2023 Sep 13:1-10. doi: 10.1080/15360288.2023.2253241. Online ahead of print.ABSTRACTThe purpose of the study was to determine the effect of combination therapy involving opioids, steroids, benzodiazepines, anticholinergics, and antihistamines on antipsychotics efficacy for delirium. The study included adult inpatients receiving end-of-life palliative care and diagnosed with hyperactive delirium. Changes in delirium symptoms were assessed using the Intensive Care Delirium Screening Checklist (ICDSC). A retrospective analysis was conducted on 97 patients with ICDSC scores of ≥4, comparing ...
Source: Journal of Pain and Palliative Care Pharmacotherapy - September 13, 2023 Category: Palliative Care Authors: Junya Sato Rei Tanaka Source Type: research

Oxycodone Extended-Release Capsule Utilization for Pain Management in  a Cancer Palliative Care Clinic: A Retrospective Review
J Pain Palliat Care Pharmacother. 2023 Sep 13:1-12. doi: 10.1080/15360288.2023.2253248. Online ahead of print.ABSTRACTABSTRACT Xtampza ER™, an oxycodone extended-release capsule (OERC), was the first long-acting opioid to feature abuse-deterrent properties and various routes of administration without pharmacokinetic alterations. The primary objective of this study was to evaluate changes in reported pain scores after initiation of or rotation to OERC from a previous opioid. Baseline scores were from patients' outpatient visits immediately before starting OERC and were compared to those at the next two follow-up visits. S...
Source: Journal of Pain and Palliative Care Pharmacotherapy - September 13, 2023 Category: Palliative Care Authors: Jordan Fortunato Justin Kullgren Gary Houchard Jessica Hirsch Nicole Shirilla Meridith Bumb Junan Li Source Type: research