ARV-825 Showed Antitumor Activity against BRD4-NUT Fusion Protein by Targeting the BRD4
CONCLUSION: Through the induction of BRD4 protein degradation, ARV-825 can successfully limit BRD4-NUT 3T3 cell proliferation in vitro and in vivo. These findings suggested that the BRD4 inhibitor ARV-825 would be an effective therapeutic strategy for treating NUT carcinoma that with the genetic feature of BRD4-NUT fusion event.PMID:38130463 | PMC:PMC10735731 | DOI:10.1155/2023/9904143 (Source: Journal of Oncology)
Source: Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Liu Yang Yue Jing Xia Xia Xiushan Yin Source Type: research
A Natural Organic Compound "Decursin" Has Both Antitumor and Renal Protective Effects: Treatment for Osteosarcoma
In this study, the research theme was to examine the sensitizing effect of decursin and its influence on cisplatin-induced nephrotoxicity. The cell viability and half maximal inhibitory concentration (IC50), apoptosis induction, and effect on cell cycle and Akt pathways were examined. In vivo, we examine the effects of decursin on tumors and mice bodies. Additionally, the effects of the cisplatin-decursin combination were evaluated in vitro and in vivo. Decursin suppressed cell viability and induced apoptosis via the cell cycle. Decursin also inhibited the Akt pathway by suppressing the phosphorylation of Akt. It enhanced ...
Source: Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Daichi Hayashi Toshiharu Shirai Ryu Terauchi Shinji Tsuchida Naoki Mizoshiri Yuki Mori Seiji Shimomura Osam Mazda Kenji Takahashi Source Type: research
