ARV-825 Showed Antitumor Activity against BRD4-NUT Fusion Protein by Targeting the BRD4

CONCLUSION: Through the induction of BRD4 protein degradation, ARV-825 can successfully limit BRD4-NUT 3T3 cell proliferation in vitro and in vivo. These findings suggested that the BRD4 inhibitor ARV-825 would be an effective therapeutic strategy for treating NUT carcinoma that with the genetic feature of BRD4-NUT fusion event.PMID:38130463 | PMC:PMC10735731 | DOI:10.1155/2023/9904143
Source: Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research