A Natural Organic Compound "Decursin" Has Both Antitumor and Renal Protective Effects: Treatment for Osteosarcoma
In this study, the research theme was to examine the sensitizing effect of decursin and its influence on cisplatin-induced nephrotoxicity. The cell viability and half maximal inhibitory concentration (IC50), apoptosis induction, and effect on cell cycle and Akt pathways were examined. In vivo, we examine the effects of decursin on tumors and mice bodies. Additionally, the effects of the cisplatin-decursin combination were evaluated in vitro and in vivo. Decursin suppressed cell viability and induced apoptosis via the cell cycle. Decursin also inhibited the Akt pathway by suppressing the phosphorylation of Akt. It enhanced ...
Source: Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Daichi Hayashi Toshiharu Shirai Ryu Terauchi Shinji Tsuchida Naoki Mizoshiri Yuki Mori Seiji Shimomura Osam Mazda Kenji Takahashi Source Type: research
Polypeptide N-Acetylgalactosaminyltransferase 14 (GALNT14) as a Chemosensitivity-Related Biomarker for Osteosarcoma
CONCLUSION: We identified a GALNT family gene, GALNT14, that was highly expressed in osteosarcoma. This gene was closely associated with metastasis, progression, cuproptosis-related genes, and chemosensitivity of osteosarcoma, and showed correlation with poor overall survival and disease-free survival in osteosarcoma.PMID:38024474 | PMC:PMC10681776 | DOI:10.1155/2023/1083423 (Source: Journal of Oncology)
Source: Journal of Oncology - November 29, 2023 Category: Cancer & Oncology Authors: Qiong Xi Jinqi Ma Source Type: research
