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Neural correlates of face processing associated with development of social communication in 12-month infants with familial risk of autism spectrum disorder
ConclusionsIn 12-month-old infant siblings with subsequent ASD, increased P400 response to Mother over Stranger faces is positively associated with concurrent language and future social skills. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - January 12, 2022 Category: Neurology Source Type: research

Social communication in fragile X syndrome: pilot examination of the Brief Observation of Social Communication Change (BOSCC)
ConclusionsThe BOSCC-MV shows promise as a FXS social communication outcome measure, warranting further large-scale evaluation. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - January 8, 2022 Category: Neurology Source Type: research

Feasibility of delivering parent-implemented NDBI interventions in low-resource regions: a pilot randomized controlled study
ConclusionsEven though the experimental parent group averaged less than 30 min of intervention weekly with providers in the 6 months, both providers and parents demonstrated statistically significant gains on the fidelity of implementation scores with moderate effect sizes compared to control groups. Since child changes in parent-mediated models are dependent upon the parents ’ ability to deliver the intervention, and since parent delivery is dependent upon providers who are coaching the parents, these results demonstrated that two of these three links of the chain were positively affected by the experimental implementat...
Source: Journal of Neurodevelopmental Disorders - January 5, 2022 Category: Neurology Source Type: research

Trajectories of imitation skills in preschoolers with autism spectrum disorders
ConclusionsThe clinical implications of the findings are discussed, particularly the impact of an early imitation deficit on other areas of competence of the young child. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - January 5, 2022 Category: Neurology Source Type: research

Behavioural and psychological features of PTEN mutations: a systematic review of the literature and meta-analysis of the prevalence of autism spectrum disorder characteristics
ConclusionsExisting research suggests approximately 25% of people with constitutionalPTEN mutations may meet criteria for or have characteristics of ASD. Studies have also begun to establish a range of possible cognitive impairments in affected individuals, especially when ASD is also reported. However, further large-scale studies are needed to elucidate psychological/behavioural corollaries of this mutation, and how they may relate to physiological/physical characteristics. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - January 4, 2022 Category: Neurology Source Type: research

Correction to: The prevalence and profile of autism in individuals born preterm: a systematic review and meta-analysis
(Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - December 24, 2021 Category: Neurology Source Type: research

Patterns of psychopathology and cognition in sex chromosome aneuploidy
ConclusionsThere is domain-specific variation in psychopathology across SCA groups and domain-specific correlation between psychopathology and IQ within SCAs. These findings (i) help to tailor clinical assessment of this common and impactful family of genetic disorders and (ii) suggest that dosage abnormalities of X- and Y-linked genes impart somewhat distinct profiles of neuropsychiatric risk. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - December 15, 2021 Category: Neurology Source Type: research

Symptom rates and profile clustering in tuberous sclerosis complex-associated neuropsychiatric disorders (TAND)
ConclusionThis study is the first to identify natural phenotypic profiles of TAND symptoms. Study of specific TAND subpopulations with shared profiles may facilitate better understanding of the underlying biology of TAND and better assessment of more targeted treatments. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - December 13, 2021 Category: Neurology Source Type: research

MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice
ConclusionsOur data supports that MeCP2 is an essential component of HPA axis reprogramming and underlies the differential response to anxiogenic situations later in life. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - December 11, 2021 Category: Neurology Source Type: research

Social visual attentional engagement and memory in Phelan-McDermid syndrome and autism spectrum disorder: a pilot eye tracking study
ConclusionThese findings demonstrate further evidence of differences in attention and memory for social stimuli in ASD and provide contrasts between iASD and PMS. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - December 4, 2021 Category: Neurology Source Type: research

Prediction of autism spectrum disorder diagnosis using nonlinear measures of language-related EEG at 6 and 12 months
ConclusionsThese results demonstrate that speech processing EEG measures can facilitate earlier identification of ASD but emphasize the need for age-specific predictive models with large sample sizes to develop clinically relevant classification algorithms. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - November 30, 2021 Category: Neurology Source Type: research

Developing and evaluating treatments for the challenges of autism and related neurodevelopmental disabilities
(Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - November 17, 2021 Category: Neurology Source Type: research

Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications
ConclusionsAnimal models of SHANK3 deficiency generated by various genetic strategies, which determine the composition of the residual SHANK3-isoforms and affected cell types, show phenotypes resembling ASD and PMDS. The phenotypic heterogeneity across multiple models and studies resembles the variation of clinical severity in human ASD and PMDS patients. Multiple therapeutic strategies have been proposed and tested in animal models, which might lead to translational implications for human patients with ASD and/or PMDS. Future studies should explore the effects of new therapeutic approaches that target genetic haploinsuffi...
Source: Journal of Neurodevelopmental Disorders - November 16, 2021 Category: Neurology Source Type: research

Pleiotropy between language impairment and broader behavioral disorders —an investigation of both common and rare genetic variants
ConclusionsOur study provides, for the first time, to our knowledge, genetic evidence for ASD subtypes based on risk variants for language impairment. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - November 13, 2021 Category: Neurology Source Type: research

Parent-reported measure of repetitive behavior in Phelan-McDermid syndrome
ConclusionsThe RBS-R total overall score in a PMS cohort appears milder compared to individuals with ASD characterized in previous studies. Stereotypic behavior in PMS may reflect cognitive functioning. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - November 5, 2021 Category: Neurology Source Type: research