Journal of Neurodevelopmental Disorders 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Early life stress and development: potential mechanisms for adverse outcomes
ConclusionsEarly life stress has persistent and pervasive effects on prefrontal –hypothalamic–amygdala and dopaminergic circuits that are at least partially mediated by alterations in hypothalamic–pituitary–adrenal axis function. However, to date, this research has primarily utilized methods of assessment that focus solely on children’s event exposures. Incorporating assessment of factors that influence children’s interpretation of stressors, along with stressful events, has the potential to provide further insight into the mechanisms contributing to individual differences in neurodevelopmental effects of early...
Source: Journal of Neurodevelopmental Disorders - December 16, 2020 Category: Neurology Source Type: research
Stunting and lead: using causal mediation analysis to better understand how environmental lead exposure affects cognitive outcomes in children
ConclusionsWe used a novel method of mediation analysis to test whether stunting mediated the adverse effect of prenatal lead exposure on cognitive outcomes in Bangladesh. While we did not find that stunting acted as mediator of lead’s effect on cognitive development, we found significant effect modification by stunting. Our results suggest that children with stunting are mo re vulnerable to the adverse effects of low-level lead exposure. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - December 16, 2020 Category: Neurology Source Type: research
Investigating the impact of the environment on neurodevelopmental disorder
(Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - December 16, 2020 Category: Neurology Source Type: research
Risk of neurodevelopmental disorders in children born from different ART treatments: a systematic review and meta-analysis
ConclusionsPooled estimates suggest that children born after ART are at higher risk of acquiring cerebral palsy. ICSI treatment causes higher risk of intellectual disability and ASD. These findings suggest the importance of the availability of intensive care unit at the time of delivery and long-term developmental evaluation particularly in children from ICSI. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - December 13, 2020 Category: Neurology Source Type: research
Sleep characteristics and problems of 2-year-olds with Williams syndrome: relations with language and behavior
ConclusionsThe relations of nighttime sleep duration, positive screens for SRBD, and excessive daytime sleepiness to language and behavior in toddlers with WS parallel prior findings for typically developing toddlers. These results highlight the importance of screening young children with WS for sleep problems. Studies investigating the efficacy of behavioral strategies for improving sleep in children with WS are warranted. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - November 20, 2020 Category: Neurology Source Type: research
Telehealth-enabled behavioral treatment for problem behaviors in boys with fragile X syndrome: a randomized controlled trial
ConclusionsThese findings support telehealth-enabled FCT as a framework for expanding access to behavioral treatments for problem behaviors in children with FXS. Expanded delivery of behavior analytic treatment via telehealth also has the potential to lower healthcare costs, improve child and family quality of life, and lead to advances in the treatment of problem behavior in the broader population of individuals with neurodevelopmental disorders.Trial registrationClinicalTrials.gov,NCT03510156. Registered 27 April 2018 (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - November 20, 2020 Category: Neurology Source Type: research
Affective and psychotic reactivity to daily-life stress in adults with 22q11DS: a study using the experience sampling method
ConclusionThe results point toward higher levels of negative affect and differences in the perception of daily hassles in 22q11DS but no difference in affective or psychotic reactivity to stress. This study contributes to the growing literature regarding the impact of stress on the development of psychopathology in the 22q11DS population. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - November 13, 2020 Category: Neurology Source Type: research
A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance
ConclusionsOur results suggest that inhibition of the JAK/STAT pathway is a new potential pathway to reinstateMeCP2 gene expression as an efficient RTT treatment. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - November 10, 2020 Category: Neurology Source Type: research
Deficits in higher visual area representations in a mouse model of Angelman syndrome
ConclusionAssaying downstream, or “higher” circuitry may provide a more sensitive measure for circuit dysfunction in mouse models of neurodevelopmental disorders.Trial registrationNot applicable. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - October 19, 2020 Category: Neurology Source Type: research
Deficits in skilled motor and auditory learning in a rat model of Rett syndrome
ConclusionsTogether, these findings illustrate novel deficits in skilled learning consistent with clinical manifestation of Rett syndrome and provide a framework for development of therapeutic strategies to improve these complex behaviors. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - September 27, 2020 Category: Neurology Source Type: research
Protective role of mirtazapine in adult female Mecp2 +/ − mice and patients with Rett syndrome
ConclusionsThis study provides the first evidence that long-term treatment of adult female heterozygousMecp2tm1.1Bird mice and adult Rett patients with the antidepressant mirtazapine is well tolerated and that it protects from disease progression and improves motor, sensory, and behavioral symptoms. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - September 27, 2020 Category: Neurology Source Type: research
Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia
ConclusionsThe combined data suggest that missense variants inNRXN1 could be associated with phenotypes of neurodevelopmental disorders beyond the diagnosis of ASD and/or SCZ. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - September 16, 2020 Category: Neurology Source Type: research
Natural clusters of tuberous sclerosis complex (TSC)-associated neuropsychiatric disorders (TAND): new findings from the TOSCA TAND research project
ConclusionsResults from this TOSCA research project in an independent international data set showed that the combination of cluster analysis and factor analysis may be able to identify clinically meaningful natural TAND clusters. Findings were remarkably similar to those identified in the earlier feasibility study, supporting the potential robustness of these natural TAND clusters. Further steps should include examination of larger samples, investigation of internal consistency, and evaluation of the robustness of the proposed natural clusters. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - August 31, 2020 Category: Neurology Source Type: research
Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation
ConclusionsOur DNAm data provide insights into the regulatory changes associated with genetic variation, highlighting their potential utility both in directing GWAS and in elucidating the pathophysiology of neurodevelopmental disorders. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - August 15, 2020 Category: Neurology Source Type: research
Properties of beta oscillations in Dup15q syndrome
ConclusionsIn this era of precision health, with pharmacological and neuromodulatory therapies being developed and tested for specific genetic etiologies of neurodevelopmental disorders, quantification and examination of mechanistic biomarkers can greatly improve clinical trials. To this end, the robust beta oscillations evident in Dup15q syndrome are clinically reproducible and stable over time. With future preclinical and computational studies that will help disentangle the underlying mechanism, it is possible that this biomarker could serve as a robust measure of drug target engagement or a proximal outcome measure in f...
Source: Journal of Neurodevelopmental Disorders - August 12, 2020 Category: Neurology Source Type: research
