Sympathetic nerve-adipocyte interactions in response to acute stress
AbstractPsychological stress predisposes our body to several disorders. Understanding the cellular and molecular mechanisms involved in the physiological responses to psychological stress is essential for the success of therapeutic applications. New studies show, by using in vivo inducible Cre/loxP-mediated approaches in combination with pharmacological blockage, that sympathetic nerves, activated by psychological stress, induce brown adipocytes to produce IL-6. Strikingly, this cytokine promotes gluconeogenesis in hepatocytes, that results in the decline of tolerance to inflammatory organ damage. The comprehension arising...
Source: Journal of Molecular Medicine - November 4, 2021 Category: Molecular Biology Source Type: research
Correction to: Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat
(Source: Journal of Molecular Medicine)
Source: Journal of Molecular Medicine - November 1, 2021 Category: Molecular Biology Source Type: research
Correction to: Arginine derivatives in atrial fibrillation progression phenotypes
(Source: Journal of Molecular Medicine)
Source: Journal of Molecular Medicine - October 30, 2021 Category: Molecular Biology Source Type: research
Genetic abnormalities in biopsy-proven, adult-onset hemolytic uremic syndrome and C3 glomerulopathy
In this study, a retrospective adult cohort of 35 patients with biopsy-proven thrombotic microangiopathy (the largest in Canada) and 10 patients with C3 glomerulopathy was tested through an extended exome panel to identify causative defects in associated or candidate genes including those of the alternative and terminal complement pathways. A variant of unknown significance was also analyzed for pathogenicity through in vitro studies. To our surprise, the prevalence of known causative or risk-associated variants in either of these cohorts was found to be less than ~ 15% overall. However, the panel used and analyses ca...
Source: Journal of Molecular Medicine - October 29, 2021 Category: Molecular Biology Source Type: research
The vasculature niches required for hematopoiesis
AbstractEndothelial cells play a critical role in supporting postnatal hematopoiesis in the bone marrow. Unique endothelial cells, together with various perivascular cells, form different types of vascular structures, constructing a vast microvascular delivery and trafficking network for blood cells, oxygen, and nutrition. These blood vessels build distinct hematopoietic stem and progenitor cell niches, which offer not only sites of residence for blood cells but also indispensable signals directing HSPC homing, self-renewal, and multilineage differentiation. Deep insight into the structure and function of the BM vasculatur...
Source: Journal of Molecular Medicine - October 28, 2021 Category: Molecular Biology Source Type: research
