Regulation of endothelial progenitor cell functions during hyperglycemia: new therapeutic targets in diabetic wound healing
AbstractDiabetes is primarily characterized by hyperglycemia, and its high incidence is often very costly to patients, their families, and national economies. Unsurprisingly, the number and function of endothelial progenitor cells (EPCs) decrease in patients resulting in diabetic wound non-healing. As precursors of endothelial cells (ECs), these cells were discovered in 1997 and found to play an essential role in wound healing. Their function, number, and role in wound healing has been widely investigated. Hitherto, a lot of complex molecular mechanisms have been discovered. In this review, we summarize the mechanisms of h...
Source: Journal of Molecular Medicine - January 8, 2022 Category: Molecular Biology Source Type: research
A comprehensive review on phytochemicals for fatty liver: are they potential adjuvants?
AbstractNon-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome and, as such, is associated with obesity. With the current and growing epidemic of obesity, NAFLD is already considered the most common liver disease in the world. Currently, there is no official treatment for the disease besides weight loss. Although there are a few synthetic drugs currently being studied, there is also an abundance of herbal products that could also be used for treatment. With theWorld Health Organization (WHO) traditional medicine strategy (2014 –2023) in mind, this review aims to analyze th...
Source: Journal of Molecular Medicine - January 7, 2022 Category: Molecular Biology Source Type: research
Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway
This study revealed for the first time the expression mechanism of MMP-7, which is one of the causes of LPRD. (Source: Journal of Molecular Medicine)
Source: Journal of Molecular Medicine - January 1, 2022 Category: Molecular Biology Source Type: research
Retraction Note: Radiation-induced glucocorticoid receptor promotes CD44 + prostate cancer stem cell growth through activation of SGK1-Wnt/β-catenin signaling
(Source: Journal of Molecular Medicine)
Source: Journal of Molecular Medicine - December 10, 2021 Category: Molecular Biology Source Type: research
Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology
AbstractNa+/K+-ATPase (NKA) is a large transmembrane protein expressed in all cells. It is well studied for its ion exchanging function, which is indispensable for the maintenance of electrochemical gradients across the plasma membrane and herein neuronal excitability. The widely recognized pump function of NKA closely depends on its unique structure features and conformational changes upon binding of specific ions. Various Na+-dependent secondary transport systems are rigorously controlled by the ionic gradients generated by NKA and are essential for multiple physiological processes. In addition, roles of NKA as a signal ...
Source: Journal of Molecular Medicine - November 27, 2021 Category: Molecular Biology Source Type: research
Advances in gene therapy for neurogenetic diseases: a brief review
AbstractNeurogenetic diseases are neurological conditions with a genetic cause (s). There are thousands of neurogenetic diseases, and most of them are incurable. The development of bioinformatics and elucidation of the mechanism of pathogenesis have allowed the development of gene therapy approaches, which show great potential in treating neurogenetic diseases. Viral vectors delivery, antisense oligonucleotides, gene editing, RNA interference, and burgeoning viroid delivery technique are promising gene therapy strategies, and commendable therapeutic effects in the treatment of neurogenetic diseases have been achieved (Fig....
Source: Journal of Molecular Medicine - November 27, 2021 Category: Molecular Biology Source Type: research
Targeting the Wnt signaling pathway for breast cancer bone metastasis therapy
AbstractOsteolytic bone destruction is found in approximately 60% of advanced breast cancer patients. With the pathogenesis of bone metastasis being unclear, traditional antiresorptive therapeutic strategies might not be ideal for treatment. The Wnt pathway is a highly organized cascade involved in multiple stages of cancer bone metastasis, and Wnt-targeted therapeutic strategies have shown promise in achieving favorable outcomes. In this review, we summarize the current progress of pharmacological Wnt modulators against breast cancer bone metastasis, discuss emerging therapeutic strategies based on Wnt pathway-related tar...
Source: Journal of Molecular Medicine - November 25, 2021 Category: Molecular Biology Source Type: research
Correction to: The vasculature niches required for hematopoiesis
(Source: Journal of Molecular Medicine)
Source: Journal of Molecular Medicine - November 24, 2021 Category: Molecular Biology Source Type: research
Sexual dimorphism in cardiac remodeling: the molecular mechanisms ruled by sex hormones in the heart
AbstractHeart failure (HF) is growing in prevalence, due to an increase in aging and comorbidities. Heart failure with reduced ejection fraction (HFrEF) is more common in men, whereas heart failure with preserved ejection fraction (HFpEF) has a higher prevalence in women. However, the reasons for these epidemiological trends are not clear yet. Since HFpEF affects mostly postmenopausal women, sex hormones should play a pivotal role in HFpEF development. Furthermore, for HFpEF, contrary to HFrEF, effective therapeutic approaches are missing. Interestingly, studies evidenced that some therapies can have better results in wome...
Source: Journal of Molecular Medicine - November 23, 2021 Category: Molecular Biology Source Type: research
Circulating tumor cells in colorectal cancer in the era of precision medicine
This study reviewed the existing CTC isolation techniques and their applications in the clinical diagnosis and treatment of CRC. The study also presented their limitations and provided future research directions. (Source: Journal of Molecular Medicine)
Source: Journal of Molecular Medicine - November 20, 2021 Category: Molecular Biology Source Type: research
Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence
AbstractThe aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that can be activated by structurally diverse compounds arising from the environment and the microbiota and host metabolism. Expanding evidence has been shown that the modulation of the canonical pathway of AHR occurs during several chronic diseases and that its abrogation might be of clinical interest for metabolic and inflammatory pathological processes. However, most of the evidence on the pharmacological abrogation of the AHR-CYP1A1 axis has been reported in vitro, and therefore, guidance for in vivo studies is needed. In this review...
Source: Journal of Molecular Medicine - November 20, 2021 Category: Molecular Biology Source Type: research
Androgen-dependent tissue factor pathway inhibitor regulating protein: a review of its peripheral actions and association with cardiometabolic diseases
AbstractThe first genome-wide association study on coronary artery disease (CAD) in the Han Chinese population identifiedC6orf105 as a susceptibility gene. TheC6orf105 gene was later found to encode for a protein that regulates tissue factor pathway inhibitor (TFPI) expression in endothelial cells in an androgen-dependent manner, and the novel protein was thus termed androgen-dependent TFPI-regulating protein (ADTRP). Since the identification of ADTRP, there have been several studies associating genetic variants on the ADTRP gene with CAD risk, as well as research providing mechanistic insights on this novel protein and it...
Source: Journal of Molecular Medicine - November 19, 2021 Category: Molecular Biology Source Type: research
Discriminating head trauma outcomes using machine learning and genomics
This study illustrates how ML methods in combination with WES data have the potential to predict severe or prolonged responses to head traum a from healthy recovery.Key messagesLinear association analysis has been inconclusive in concussion genetics.Non-linear methods as boosted trees can offer better insights in small samples.Strong discrimination trends can be achieved from exome data of cases and controls. (Source: Journal of Molecular Medicine)
Source: Journal of Molecular Medicine - November 19, 2021 Category: Molecular Biology Source Type: research
Bone marrow adiposity during pathologic bone loss: molecular mechanisms underlying the cellular events
AbstractBone marrow (BM) is a heterogeneous niche where bone marrow stromal cells (BMSCs), osteoblasts, osteoclasts, adipocytes, hematopoietic cells, and immune cells coexist. The cellular composition of BM changes with various pathophysiological states. A reduction in osteoblast number and a concomitant increase in adipocyte number in aging and pathological conditions put bone marrow adipose tissue (BMAT) into spotlight. Accumulating evidence strongly supports that an overwhelming production of BMAT is a major contributor to bone loss disorders. Therefore, BMAT-targeted therapy can be an efficient and feasible interventio...
Source: Journal of Molecular Medicine - November 9, 2021 Category: Molecular Biology Source Type: research
Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations
AbstractThe risk of severe COVID-19 increases with age as older patients are at highest risk. Thus, there is an urgent need to identify how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with blood components during aging. We investigated the whole blood transcriptome from the Genotype-Tissue Expression (GTEx) database to explore differentially expressed genes (DEGs) translated into proteins interacting with viral proteins during aging. From 22 DEGs in aged blood,FASLG,CTSW,CTSE,VCAM1, andBAG3 were associated with immune response, inflammation, cell component and adhesion, and platelet activation/ag...
Source: Journal of Molecular Medicine - November 6, 2021 Category: Molecular Biology Source Type: research
