Journal of Labelled Compounds and Radiopharmaceuticals This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Development of an automated production process of [64Cu][Cu (ATSM)] for positron emission tomography imaging and theranostic applications
Various production methods of [64Cu][Cu (ATSM)] exist, but non-standardized equipment results in varying production qualities often not easily implemented in wider hospital settings. [64Cu][Cu (ATSM)] was synthesized on a modified GE TRACERlab FXN automated synthesis module with high molar activity and good radiostability over 20 h. We demonstrate a simple and feasible synthesis of [64Cu][Cu (ATSM)] based on commercially distributed standardized synthesis modules suitable for PET imaging and theranostic studies of tumor microenvironment hypoxia. Cyclotron-produced copper-64 radioisotope tracers offer the possibility to per...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - April 29, 2022 Category: Biochemistry Authors: Tengzhi Liu, Kathrine R øe Redalen, Morten Karlsen Tags: PRACTITIONER PROTOCOL ‐ SYNTHESIS Source Type: research

Novel developed HPLC analyses of [68Ga]Ga/[177Lu]Lu ‐EDTMP and [68Ga]Ga/[177Lu]Lu‐DOTA‐Zoledronate
Practical and realible R-HPLC analyses of [68Ga]Ga/[177Lu]Lu-EDTMP and [177Lu]Lu-DOTA-Zoledronate were exhibited for the first time. Radiolabeled phosphonates have found widespread applications in nuclear medicine for the treatment of bone metastases. Even though considerable attention has been devoted to the administration of radiolabeled phosphonates to the patients, quality control (QC) studies belong to detection of them are still speculative and need to be improved. Herein, practical, efficient, and more reliable high-performance liquid chromatograpy (HPLC) methods were described for the first time. Radiochemical puri...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - April 27, 2022 Category: Biochemistry Authors: Kurtulus Eryilmaz, Hasan Ensar Bakar, Benan Kilbas Tags: RESEARCH ARTICLE Source Type: research

Issue Information
No abstract is available for this article. (Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - April 26, 2022 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Automated Radiochemical Synthesis of Pharmaceutical Grade [18F]FLT using 3 ‐N‐Boc‐5’‐O‐dimethoxytrityl‐3’‐O‐nosyl‐thymidine precursor and its Sep‐Pak® Purification employing Selective Elution from Reversed Phase
Pharmaceutical grade 3 ’-deoxy-3’-[18F]fluorothymidine [18F]FLT was synthesized using 3-N-Boc-5 ’-O-dimethoxytrityl-3’-O-nosyl-thymidine (BOC-Nosyl) precursor, in the general purpose TRACERlab FX modules. Purification of [18F]FLT, via solid phase extraction (SPE) after radiosynthesis, using a combination of different SPE cartridges, yielded satisfactory results, with radiochemical and chemical purity> 99%. While the non-decay corrected radiochemical yield (RCY) with 20 mg (24 μmole) of BOC-Nosyl precursor was found to be 6.80 ± 0.16 %, the decay corrected radiochemical yield (RCY) was 9.95 ± 0.24 %, Residual ...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - April 26, 2022 Category: Biochemistry Authors: Arpit Mitra, Avik Chakraborty, Trupti Upadhye, Megha Tawate, Sangita Lad, Sudeep Sahu, C. Rajesh, Swati Bagul, Yogita Pawar, Mukti Kant Ray, Sharmila Banerjee Tags: RESEARCH ARTICLE Source Type: research

Development of an Automated Production Process of [64Cu][Cu (ATSM)] for PET imaging and theranostic Applications
(Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - April 25, 2022 Category: Biochemistry Authors: Tengzhi Liu, Kathrine R øe Redalen, Morten Karlsen Tags: PRACTITIONER PROTOCOL ‐ SYNTHESIS Source Type: research

Novel developed HPLC analyses of [68Ga]Ga/[177Lu]Lu ‐EDTMP and [68Ga]Ga/[177Lu]Lu‐DOTA‐Zoledronate
Radiolabeled phosphonates have found widespread applications in nuclear medicine for the treatment of bone metastases. Even considerable attention has been devoted to the administration of radiolabeled phosphonates to the patients, quality control (QC) studies belongs to detection of them are still speculative and need to be improved. Herein practical, efficient and more reliable high performance liquid chromatograpy (HPLC) methods were described for the first time. Radiochemical purity was easily determined by our developed analytical methods.N,N-Dimethylhexylamine andN,N-dimethyltetradecylamine were furnished as suitable...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - April 25, 2022 Category: Biochemistry Authors: Kurtulus Eryilmaz, Hasan Ensar Bakar, Benan Kilbas Tags: RESEARCH ARTICLE Source Type: research

Issue Information
No abstract is available for this article. (Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - April 4, 2022 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

A synthesis of [14C]formamidine acetate
The one step synthesis of [14C]formamidine acetate from [14C]barium cyanamide is described with product characterization by TLC and proton NMR. (Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - March 30, 2022 Category: Biochemistry Authors: Crist N. Filer, Giliyar V. Ullas Tags: PRACTITIONER PROTOCOL ‐ SYNTHESIS Source Type: research

Synthesis of [2H5]baricitinib via [2H5]ethanesulfonyl chloride
Recently, baricitinib has attracted interest for its potential role as a therapeutic agent in the treatment of COVID-19, creating a need to develop a synthetic route to its deuterium-labelled analogue for use as a mass spectrum internal standard, since the isotopologue is typically somewhat costly. This paper presents a new synthetic route to [2H5]baricitinib from [2H5]ethanesulfonyl chloride. Since the preparation and isolation of [2H5]ethanesulfonyl chloride form a major challenge, these comprise a large focus of the overall work. Baricitinib, typically applied as a treatment for rheumatoid arthritis, has recently attrac...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - March 25, 2022 Category: Biochemistry Authors: Ross D. Jansen ‐van Vuuren, Rahul Vohra Tags: PRACTITIONER PROTOCOL ‐ SYNTHESIS Source Type: research

Automated radiosynthesis of the adenosine A2A receptor ‐targeting radiotracer [18F]FLUDA
We report herein a remotely controlled automated radiosynthesis of [18F]FLUDA using a GE TRACERlab FX2 N radiosynthesizer. The radiotracer was obtained by a one-pot two-step radiofluorination procedure (radiochemical yield: 9 ± 1%, radiochemical purity: ≥99%, molar activities: 69–333 GBq/µmol (EOS), total synthesis time: approx. 95 min). Altogether, we successfully established a reliable and reproducible procedure for the automated production of [18F]FLUDA. [18F]FLUDA is a selective radiotracer for in vivo imaging of the adenosine A2A receptor (A2AR) by positron emission tomography (PET). Promising preclinical result...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - March 25, 2022 Category: Biochemistry Authors: Thu Hang Lai, Barbara Wenzel, Rare ş‐Petru Moldovan, Peter Brust, Klaus Kopka, Rodrigo Teodoro Tags: PRACTITIONER PROTOCOL ‐ SYNTHESIS Source Type: research

Automated radiosynthesis of the adenosine A2A receptor ‐targeting radiotracer [18F]FLUDA
[18F]FLUDA is a selective radiotracer for in vivo imaging of the adenosine A2A receptor (A2AR) by positron emission tomography (PET). Promising preclinical results obtained by neuroimaging of mice and piglets suggest the translation of [18F]FLUDA to human PET studies. Thus, we report herein a remotely controlled automated radiosynthesis of [18F]FLUDA using a GE TRACERlab FX2 N radiosynthesizer. The radiotracer was obtained by a one-pot two-step radiofluorination procedure with a radiochemical yield of 9 ± 1%, a radiochemical purity of ≥ 99% and molar activities in the range of 69-333 GBq/μmol at the end of synthesis wi...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - March 15, 2022 Category: Biochemistry Authors: Thu Hang Lai, Barbara Wenzel, Rares ‐Petru Moldovan, Peter Brust, Klaus Kopka, Rodrigo Teodoro Tags: PRACTITIONER PROTOCOL ‐ SYNTHESIS Source Type: research

Issue Information
No abstract is available for this article. (Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - March 14, 2022 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research