Novel developed HPLC analyses of [68Ga]Ga/[177Lu]Lu ‐EDTMP and [68Ga]Ga/[177Lu]Lu‐DOTA‐Zoledronate

Practical and realible R-HPLC analyses of [68Ga]Ga/[177Lu]Lu-EDTMP and [177Lu]Lu-DOTA-Zoledronate were exhibited for the first time. Radiolabeled phosphonates have found widespread applications in nuclear medicine for the treatment of bone metastases. Even though considerable attention has been devoted to the administration of radiolabeled phosphonates to the patients, quality control (QC) studies belong to detection of them are still speculative and need to be improved. Herein, practical, efficient, and more reliable high-performance liquid chromatograpy (HPLC) methods were described for the first time. Radiochemical purity was easily determined by our developed analytical methods.N,N-Dimethylhexylamine andN,N-dimethyltetradecylamine were furnished as suitable ion pair reagents for the identification of radiopharmaceutical products. Effects of column type, pH of the mobile phase, and salt concentration were also examined.
Source: Journal of Labelled Compounds and Radiopharmaceuticals - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research