Journal of Labelled Compounds and Radiopharmaceuticals This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Tritium HIE with electron ‐poor tertiary benzenesulfonamide moiety; application in late‐stage labeling of T0901317
The multi-functional radioligand [3H]T0901317 ([3H]1) has been employed as a powerful autoradiographic tool to target several receptors, such as liver X, farnesoid X and retinoic acid-related orphan receptor alpha and gamma subtypes at nanomolar concentrations. Although [3H]1 is commercially available and its synthesis via tritiodebromination has been reported, the market price of this radioligand and the laborious synthesis of corresponding bromo-intermediate potentially preclude its widespread use in biochemical, pharmacological and pathological studies in research lab settings. We exploit recent reports on hydrogen-isot...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - December 28, 2021 Category: Biochemistry Authors: Yongsong Tian, B řetislav Brož, František Tureček, Aleš Marek Tags: RESEARCH ARTICLE Source Type: research

Issue Information
No abstract is available for this article. (Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - December 3, 2021 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Radiolabeling and brain penetration of [11C]VU0071063, a ligand of type 1 sulfonylurea receptors for positron emission tomography imaging
Automated isotopic carbon-11 radiolabeling of SURI ligand VU0071063 was successfully developed to demonstrate in vivo the brain penetration of this tracer in healthy rats using PET imaging. Sulfonylurea receptor 1 (SUR1) overexpression in the central nervous system is a potential biomarker for positron emission tomography (PET) imaging of brain damage and recovery. VU0071063, a selective ligand of SUR1 able to cross the blood –brain barrier, was isotopically radiolabeled with carbon-11 from a desmethyl precursor obtained quantitatively in one step. Ready-to-inject [11C]VU0071063 was obtained in 18 ± 2% radiochemical...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - December 1, 2021 Category: Biochemistry Authors: Fabien Caill é, Wadad Saba, Sébastien Goutal, Louise Breuil, Bertrand Kuhnast, Nicolas Tournier Tags: RESEARCH ARTICLE Source Type: research