Journal of Labelled Compounds and Radiopharmaceuticals This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Featured Cover
The cover image is based on different strategies covered within this issue used for crossing the blood brain barrier.SMS would like to acknowledge Simon Zientek (University of Cambridge) for helpful discussion about the cover image. (Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - July 21, 2023 Category: Biochemistry Tags: FEATURED COVER Source Type: research

Issue Information
No abstract is available for this article. (Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - July 21, 2023 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Blood Brain Barrier – tactics and attributes in developing successful neuroimaging agents
(Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - July 21, 2023 Category: Biochemistry Authors: Selena Milicevic Sephton, Stephen Thompson Tags: EDITORIAL Source Type: research

A practical approach to the optimization of positron emission tomography imaging agents for the central nervous system
(Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - July 21, 2023 Category: Biochemistry Tags: NOTE Source Type: research

Blood Brain Barrier – tactics and attributes in developing successful neuroimaging agents
(Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - July 7, 2023 Category: Biochemistry Authors: Selena Milicevic Sephton, Stephen Thompson Tags: EDITORIAL Source Type: research

Development of an economical method to synthesize O ‐(2‐[18F]fluoroethyl)‐L‐tyrosine (18FFET)
In this study, we are reporting the experience of synthesis [18F]FET by varying the concentration of TET precursor in different chemistry modules. TET precursor (2 –10 mg) was used for the synthesis of [18F]FET in an automated (MX Tracerlab) module (n = 6) and semiautomated (FX2N Tracerlab) module (n = 19). The quality control was performed for all the preparations. For human imaging, 220 ± 50 MBq of [18F]FET was briefly injected into the patient to acquire PET-MR images. The radiochemical purity was greater than 95% for the final product in both modules. The decay corrected average yield was 10.7 ±�...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - July 6, 2023 Category: Biochemistry Authors: Aishwarya Kumar, Raman Kumar Joshi, Riptee Thakur, Dinesh Kumar, Chandana Nagaraj, Pardeep Kumar Tags: RESEARCH ARTICLE Source Type: research

Carbon 14 synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites
Iclepertin (BI 425809) is a potent and selective GlyT-1 inhibitor being developed for the treatment of schizophrenia. It was prepared labeled with carbon 14 using two synthetic routes to incorporate the radioactive carbon in two locations of the molecule. The synthesis of major metabolites labeled with carbon 14 is also described. Carbon 14 labeledIclepertin (BI 425809,1) and its major metabolites were needed for ADME and several other studies necessary for the advancement of this drug candidate in clinical trials. Iclepertin is composed of two main chemical blocks, (R)-5-(methylsulfonyl)-2-([1,1,1-trifluoropropan-2-yl]oxy...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - July 4, 2023 Category: Biochemistry Authors: Bachir Latli, Matt J. Hrapchak, Rogelio P. Frutos, Heewon Lee, Jinhua J. Song Tags: RESEARCH ARTICLE Source Type: research

Mild and selective hydrogen –deuterium exchange for aromatic hydrogen of amines
The direct deuteration of the aromatic moiety in aromatic and aralkyl amines by deuterated trifluoromethanesulfonic acid is reported. Short reaction times and a high degree of aromatic deuteration are achieved, and isolation of the product is simple. The optical activity of the chiral aralkyl amines studied was preserved. The direct electrophilic deuteration of the aromatic moiety in aromatic and aralkyl amines is reported. The acid-catalyzed deuteration is facilitated by deuterated trifluoromethanesulfonic acid, [D]triflic acid, CF3SO3D, TfOD, which acts as both the reaction solvent and the source of the deuterium label. ...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - June 20, 2023 Category: Biochemistry Authors: Zetryana Puteri Tachrim, Manami Hashinoki, Zeping Wang, Zhang Wen, Zhuang Zihan, Makoto Hashimoto Tags: RESEARCH ARTICLE Source Type: research

Issue Information
No abstract is available for this article. (Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - June 19, 2023 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research