Journal of Labelled Compounds and Radiopharmaceuticals This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Synthesis of N ‐acetyl‐L‐aspartyl‐L‐glutamic acid; [3H]NAAG
[3H]NAAG,N-acetyl-L-aspartyl-L-glutamic acid has been widely used as a substrate in glutamate carboxypeptidase II (GCPII) reactions, either to determine the inhibitory constants at 50% inhibition (IC50) of novel compounds or to measure GCPII activities in different tissues harvested from various disease models. The importance of [3H]NAAG, combined with its current commercial unavailability, prompted the development of a reliable eight-step synthetic procedure towards [3H2]NAAG starting from commercially available pyroglutamate. Pure [3H]NAAG of high molar activity (49.8 Ci/mmol) and desired stereochemistry was isolated in ...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - July 19, 2022 Category: Biochemistry Authors: Michal Kriegelstein, Ale š Marek Tags: RESEARCH ARTICLE Source Type: research

Determination of isotope abundance for deuterium ‐labeled compounds by quantitative 1H NMR + 2H NMR
1H NMR  + 2H NMR method can obtain the isotope abundance of deuterium reagents by employing a single NMR tube. It has promising application potential for the evaluation of deuterium abundance and in the quality control process for deuterated reagents. Deuterated reagents have been used in many research fields. Isotope abundance, as the feature parameter of deuterated reagents, the precise quantification, is of great importance. Based on quantitative nuclear magnetic resonance technology, a novel method that combines1H NMR  + 2H NMR was systematically established to determine the isotopic abundance of deuterated rea...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - July 5, 2022 Category: Biochemistry Authors: Long Xie, Yameng Zhao, Liyan Sheng, Shancheng Feng, An Shen, Yanqiu Chen, Cheng Zhao, Mingming Song, Yucai Hu, Wen Lei Tags: RESEARCH ARTICLE Source Type: research

Determination of Isotope Abundance for Deuterium ‐labeled Compounds by Quantitative 1H NMR + 2H NMR
Deuterated reagents have been used in many research fields. Isotope abundance, as the feature parameter of deuterated reagents, the precise quantification is of great importance. Based on quantitative nuclear magnetic resonance technology, a novel method that combines1H NMR +2H NMR was systematically established to determine the isotopic abundance of deuterated reagents. The results showed that the isotopic abundance of partially labeled and fully labeled compounds calculated by this new method was even more accurate than that calculated by classical1H NMR and MS methods. In brief, this new method is a robust strategy for ...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - June 30, 2022 Category: Biochemistry Authors: Long Xie, Yameng Zhao, Liyan Sheng, Shancheng Feng, An Shen, Yanqiu Chen, Cheng Zhao, Mingming Song, Yucai Hu, Wen Lei Tags: RESEARCH ARTICLE Source Type: research

Issue Information
No abstract is available for this article. (Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - June 8, 2022 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Automated radiochemical synthesis of pharmaceutical grade [18F]FLT using 3 ‐N‐Boc‐5′‐O‐dimethoxytrityl‐3′‐O‐nosyl‐thymidine precursor and its Sep‐Pak® purification employing selective elution from reversed phase
Shown are the modification in TRACERlab FX radiochemistry module and the automated one-pot radiochemical synthesis of18FLT by selective elution from HLB Sep-Pak. Specifications of produced18FLT are in accordance with Investigational New Drug Program by National Cancer Institute-Cancer Imaging Program. Pharmaceutical grade 3 ′-deoxy-3′-[18F]fluorothymidine [18F]FLT was synthesized using 3-N-Boc-5 ′-O-dimethoxytrityl-3′-O-nosyl-thymidine (BOC-Nosyl) precursor, in the general purpose TRACERlab FX modules. Purification of [18F]FLT, via solid phase extraction (SPE) after radiosynthesis, using a combination of different ...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - May 17, 2022 Category: Biochemistry Authors: Arpit Mitra, Avik Chakraborty, Trupti Upadhye, Megha Tawate, Sangita Lad, Sudeep Sahu, Chinagandham Rajesh, Swati Bagul, Yogita Pawar, Mukti Kant Ray, Sharmila Banerjee Tags: RESEARCH ARTICLE Source Type: research

Automated synthesis of (R) ‐[18F]MH.MZ on the iPhase Flexlab reaction platform
A straightforward, cGMP automated raidosynthesis of [18F]MH.MZ using a single reaction module was successfully developed to support clinical trials. (R)-[18F]MH.MZ ([18F]MH.MZ) is a promising positron emission tomography (PET) radiotracer for in vivo study of the 5-HT2A receptor. To facilitate clinical trials, a fully automated radiosynthesis procedure for [18F]MH.MZ was developed using commercially available materials on the iPhase Flexlab module. The overall synthesis time was 100  min with a radiochemical yield of 7 ± 0.9% (n = 3). The radiochemical purity was greater than 99% for [18F]MH.MZ with a molar activ...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - May 7, 2022 Category: Biochemistry Authors: Adam J. Rosenberg, Yiu ‐Yin Cheung, Fei Liu, Todd E. Peterson, James Silverman, Ciaran M. Considine, Daniel O. Claassen Tags: PRACTITIONER PROTOCOL ‐ SYNTHESIS Source Type: research

Issue Information
No abstract is available for this article. (Source: Journal of Labelled Compounds and Radiopharmaceuticals)
Source: Journal of Labelled Compounds and Radiopharmaceuticals - May 5, 2022 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Automated Synthesis of (R) ‐[18F F]MH.MZ on the iPhase Flexlab Reaction Platform
(R)-[18F]MH.MZ ([18F]MH.MZ) is a promising positron emission tomography (PET) radiotracer forin vivo study of the 5-HT2A receptor. To facilitate clinical trials a fully automated radiosynthesis procedure for [18F]MH.MZ was developed using commercially available materials on the iPhase Flexlab module. The overall synthesis time was 100 minutes with a radiochemical yield of 7 ± 0.9% (n=3). The radiochemical purity was greater than 99% for [18F]MH.MZ with a molar activity of 361 ± 57 GBq/μmol (n=3). The protocol described herein reliably provides [18F]MH.MZ that meets all relevant release criteria for a GMP radiopharmaceut...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - May 2, 2022 Category: Biochemistry Authors: Adam J. Rosenberg, Yiu ‐Yin Cheung, Fei Liu, Todd E. Peterson, James Silverman, Ciaran M. Considine, Daniel O. Claassen Tags: PRACTITIONER PROTOCOL ‐ SYNTHESIS Source Type: research