Automated Synthesis of (R) ‐[18F F]MH.MZ on the iPhase Flexlab Reaction Platform

(R)-[18F]MH.MZ ([18F]MH.MZ) is a promising positron emission tomography (PET) radiotracer forin vivo study of the 5-HT2A receptor. To facilitate clinical trials a fully automated radiosynthesis procedure for [18F]MH.MZ was developed using commercially available materials on the iPhase Flexlab module. The overall synthesis time was 100 minutes with a radiochemical yield of 7 ± 0.9% (n=3). The radiochemical purity was greater than 99% for [18F]MH.MZ with a molar activity of 361 ± 57 GBq/μmol (n=3). The protocol described herein reliably provides [18F]MH.MZ that meets all relevant release criteria for a GMP radiopharmaceutical.
Source: Journal of Labelled Compounds and Radiopharmaceuticals - Category: Biochemistry Authors: Tags: PRACTITIONER PROTOCOL ‐ SYNTHESIS Source Type: research