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Altered Resting-State Amygdalar Functional Connectivity in Primary Angle-Closure Glaucoma Patients
CONCLUSIONS: Patients with PACG exhibit extensive resting state abnormalities with respect to the FC between the amygdala and other regions of the brain, suggesting that dysregulated amygdalar FC may play a role in the pathophysiology of PACG.PMID:38682218 | DOI:10.31083/j.jin2304075 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ye Chen Yuanyuan Wang Linglong Chen Feng Ouyang Mingxue Yin Lianjiang Lv Zihe Xu Jie Liu Xianjun Zeng Source Type: research

Decoding Typical Flight States Based on Neural Signals from the Midbrain Motor Nuclei of Pigeons
CONCLUSIONS: Our results open up possibilities for further research into the neural mechanism of avian flight and contribute to the understanding of flight behavior control in birds.PMID:38682219 | DOI:10.31083/j.jin2304072 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Long Yang Erteng Ma Lifang Yang Mengmeng Li Zhigang Shang Liaofeng Wang Zuohao Ma Jiajia Li Source Type: research

Pharmacotherapeutic Potential of Bitter Gourd ( < em > Momordica charantia < /em > ) in Age-related Neurological Diseases
J Integr Neurosci. 2024 Apr 23;23(4):86. doi: 10.31083/j.jin2304086.ABSTRACTDue to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a membe...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Seyed Mohammad Hosein Hosseini Adarmanabadi Orod Jalali Khalil Abadi Amirhossein Amiri Rozhina Tamannaeifar Sahar Balanian Mehdi Rasekhjam Mohammad Sadra Samiazar Sara Hasanpour Samira Peiravi Dorsa Alijanzadeh Mohadeseh Poudineh Hamidreza Amiri Seyed Ami Source Type: research

The Roles of Circular RNAs in Ischemic Stroke through Modulating Neuroinflammation
This study reviews the current evidence on neuroinflammatory responses, the role of circRNAs in IS and their potential mechanisms in regulating inflammatory cells, and inflammatory factors affecting IS damage. This review lays a foundation for future clinical application of circRNAs as novel biomarkers and therapeutic targets.PMID:38682221 | DOI:10.31083/j.jin2304087 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Xin Gu Lingfei Li Biao Chen Yuyao Zhang Yongji Zhou Keqin Liu Wenqin Xia Xiaoqin Li Zheng Zhang Huanqing Shi Jinyu Huang Beibei Gao Lin Jiang Anwen Shao Congguo Yin Source Type: research

Causal Relationship between Sex Hormones and Risk of Developing Common Neurodegenerative Diseases: A Mendelian Randomization Study
CONCLUSIONS: Elevated BT is associated with a reduced risk of developing ALS. Further research is needed to investigate the underlying mechanisms of action for this correlation and how it can be used as a potential target of action to reduce the risk of developing ALS.PMID:38682222 | DOI:10.31083/j.jin2304078 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Qiang Huang Qiong Li Jun-Hong Guo Source Type: research

Causal Associations between Posttraumatic Stress Disorder and COVID-19
CONCLUSIONS: Our study suggests that PTSD was associated with increased risks for COVID-19 susceptibility and severity. Early diagnosis and effective treatment of PTSD in individuals infected with the coronavirus may improve the management of the outcomes of COVID-19.PMID:38682223 | DOI:10.31083/j.jin2304068 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ancha Baranova Li Fu Yuqing Song Hongbao Cao Fuquan Zhang Source Type: research

A Modified Hybrid Brain-Computer Interface Speller Based on Steady-State Visual Evoked Potentials and Electromyogram
CONCLUSIONS: Our proposed hybrid BCI speller showed improved system speed compared with state-of-the-art systems based on SSVEP or SSVEP-EMG, and can provide a user-friendly, practical system for speller applications.PMID:38682224 | DOI:10.31083/j.jin2304073 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Sahar Sadeghi Ali Maleki Source Type: research

Changes in SLITRK1 Level in the Amygdala Mediate Chronic Neuropathic Pain-Induced Anxio-Depressive Behaviors in Mice
CONCLUSION: Our findings indicated that SLITRK1 in the amygdala plays an important role in chronic pain and related ADD, and may prove to be a potential therapeutic target for chronic NPP-ADD comorbidity.PMID:38682225 | DOI:10.31083/j.jin2304082 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ruitong Chu Ye Lu Xiaoyi Fan Chengyuan Lai Jian Li Rui Yang Zhenghua Xiang Chaofeng Han Mouli Tian Hongbin Yuan Source Type: research

Neuromyelitis Optica Spectrum Disorder in Latin America: State-of-the-Art and Current Challenges
J Integr Neurosci. 2024 Apr 7;23(4):74. doi: 10.31083/j.jin2304074.ABSTRACTNeuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease of the central nervous system characterized by severe attacks of optic neuritis, myelitis, and/or area postrema. Advances in understanding the pathophysiology of NMOSD have led to improved diagnostic and therapeutic approaches. There has been a notable increase in research efforts worldwide, including in Latin America (LATAM). In recent years, LATAM has witnessed a surge in research on NMOSD, resulting in a growing body of evidence on various aspects such as epidemiology, cl...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Edgar Carnero Contentti B árbara Eizaguirre Pablo A L ópez Berenice Silva Ver ónica A Tkachuk Santiago Tizio Ricardo Alonso Source Type: research

Thalamic Alterations in Motor Neuron Diseases: A Systematic Review of MRI Findings
CONCLUSIONS: Thalamic alterations provide valuable insights into the pathophysiology and progression of MNDs. Multimodal MRI techniques are potent tools for detecting dynamic thalamic changes, indicating structural integrity, connectivity disruption, and metabolic activity.PMID:38682227 | DOI:10.31083/j.jin2304077 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Sana Mohammadi Sadegh Ghaderi Mahdi Mohammadi Zahra Najafi Asli Pashaki Rahim Khatyal Fatemeh Mohammadian Sahar Mohammadjani Source Type: research

Health Neuroscience-How the Brain/Mind and Body Affect our Health Behavior and Outcomes
J Integr Neurosci. 2024 Apr 1;23(4):69. doi: 10.31083/j.jin2304069.ABSTRACTThis Opinion piece discusses several key research questions in health neuroscience, a new interdisciplinary field that investigates how the brain and body interact to affect our health behavior such as health mindsets, decision-making, actions, and health outcomes across the lifespan. To achieve physical, mental, and cognitive health, and promote health behavior change, we propose that the prevention and treatment of diseases should target the root causes-the dysfunction and imbalance of brain-body biomarkers, through evidence-based body-mind interv...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: YiYuan Tang Rongxiang Tang Source Type: research

Immune Ataxias: The Continuum of Latent Ataxia, Primary Ataxia and Clinical Ataxia
J Integr Neurosci. 2024 Apr 12;23(4):79. doi: 10.31083/j.jin2304079.ABSTRACTThe clinical category of immune-mediated cerebellar ataxias (IMCAs) is now recognized after 3 decades of clinical and experimental research. The cerebellum gathers about 60% of neurons in the brain, is enriched in numerous plasticity mechanisms, and presents a large variety of antigens at the neuroglial level: ion channels and related proteins, synaptic adhesion/organizing proteins, transmitter receptors, and glial cells. Cerebellar circuitry is especially vulnerable to immune attacks. After the loss of immune tolerance, IMCAs present in an acute o...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Mario Manto Hiroshi Mitoma Source Type: research

Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease
CONCLUSIONS: These results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.PMID:38682230 | DOI:10.31083/j.jin2304084 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Sydney G Hillan Anders J Asp Leena B Pramanik Aarushi A Mukerjee Carter B Mulder Wendy D Lujan Jodi L Silvernail Su-Youne Chang Suelen L Boschen J Luis Lujan Source Type: research

Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood
CONCLUSIONS: We discuss possible reasons for this discrepancy with the prior literature, including (1) the age of exposure and (2) the pattern in the previous literature that most previous demonstrations of drug exposure impairing devaluation in laboratory animals may be attributed to either drug-associated cues present in the testing environment and/or accelerated habit learning in tasks that predispose laboratory animals towards habit formation with extended training (with training procedures that should resist the formation of habits in the current experiment). However, additional research is needed to examine the effec...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ian R Davis Hayley Fisher Caitlin McLean Jackson Murray Charles L Pickens Source Type: research

Astrocyte Syncytium-A Biopower Grid System in the Brain
J Integr Neurosci. 2024 Apr 2;23(4):71. doi: 10.31083/j.jin2304071.NO ABSTRACTPMID:38682232 | DOI:10.31083/j.jin2304071 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Zhouruolan A Li Min Zhou Source Type: research