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Harnessing Big Data in Amyotrophic Lateral Sclerosis: Machine Learning Applications for Clinical Practice and Pharmaceutical Trials
J Integr Neurosci. 2024 Mar 18;23(3):58. doi: 10.31083/j.jin2303058.ABSTRACTThe arrival of genotype-specific therapies in amyotrophic lateral sclerosis (ALS) signals the dawn of precision medicine in motor neuron diseases (MNDs). After decades of academic studies in ALS, we are now witnessing tangible clinical advances. An ever increasing number of well-designed descriptive studies have been published in recent years, characterizing typical disease-burden patterns in vivo and post mortem. Phenotype- and genotype-associated traits and "typical" propagation patterns have been described based on longitudinal clinical and biom...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Ee Ling Tan Jasmin Lope Peter Bede Source Type: research

Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research

Self-Modulation of Gamma-Band Synchronization through EEG-Neurofeedback Training in the Elderly
CONCLUSION: The findings of this double-blind study align with a key criterion for successful neuromodulation, highlighting the significant potential of Gamma-band synchronization in such a process. This important outcome encourages further exploration of EEG-neurofeedback on this specific neural biomarker as a promising intervention to counter the cognitive decline that often accompanies brain aging and, eventually, to modify the progression of AD.PMID:38538229 | DOI:10.31083/j.jin2303067 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Katia Andrade Nesma Houmani Thomas Guieysse Solofo Razafimahatratra Andr é Klarsfeld G érard Dreyfus Bruno Dubois Fran çois Vialatte Takfarinas Medani Source Type: research

Blocking Pannexin 1 Channels Alleviates Peripheral Inflammatory Pain but not Paclitaxel-Induced Neuropathy
CONCLUSION: Our findings suggest that Panx1 is critical for developing peripheral inflammatory pain and acute nociception involving transient receptor potential vanilloid subtype 1 (TRPV1) but is not essential for neuropathic pain chronicity.PMID:38538230 | DOI:10.31083/j.jin2303064 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Julia Borges Paes Lemes Kaue Franco Malange Nathalia Santos Carvalho Amanda Ferreira Neves Marcia Urban-Maldonado Paula Regina Gelinski Kempe Catarine Massucato Nishijima Cecilia Costa Fagundes Celina Monteiro da Cruz Lotufo Sylvia Ottile Suadicani Carlos Source Type: research

No Frequency-Specific Effect of Transcranial Random Noise Stimulation on Resting EEG
CONCLUSIONS: These observations suggest that tRNS itself does not target or alter specific EEG frequencies. Rather, tRNS most likely interacts with the cognitive task/activity at hand to produce an observable difference in post-tRNS EEG. Positive tRNS-EEG findings from previous studies are also likely to have resulted from the interactive and cognitive activity-dependent nature of tRNS.PMID:38538231 | DOI:10.31083/j.jin2303059 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Shih-Chiang Ke Yu-Hui Lo Philip Tseng Source Type: research

Properties of the Caudal Pontine Reticular Nucleus Neurons Determine the Acoustic Startle Response in Cntnap2 KO Rats
CONCLUSIONS: Recruitment and size of PnC giant neurons are important factors for regulating the magnitude of the acoustic startle response in Cntnap2-⁣/- rats, particularly in males. These findings allow for a better understanding of increased reactivity to sound in Cntnap2-⁣/- rats and in CNTNAP2-associated disorders such as ASD.PMID:38538232 | DOI:10.31083/j.jin2303063 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Alice Zheng Rajkamalpreet S Mann Dami Solaja Brian L Allman Susanne Schmid Source Type: research

The Neural Mechanism Underlying Differentiated In-Group Versus Out-Group Face Recognition and Memory, Identification, Empathy and Pro-social Behavior: Evidence from fMRI and ERP Studies
J Integr Neurosci. 2024 Mar 1;23(3):48. doi: 10.31083/j.jin2303048.ABSTRACTIn the context of perceiving individuals within and outside of social groups, there are distinct cognitive processes and mechanisms in the brain. Extensive research in recent years has delved into the neural mechanisms that underlie differences in how we perceive individuals from different social groups. To gain a deeper understanding of these neural mechanisms, we present a comprehensive review from the perspectives of facial recognition and memory, intergroup identification, empathy, and pro-social behavior. Specifically, we focus on studies that ...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Kaizhen Peng Lili Tan Xiaomin Zhang Source Type: research

 CD6 and CCR7 as Genetic Biomarkers in Evaluating Intracranial Aneurysm Rupture Risk
CONCLUSIONS: The identified two-gene signature (CD6-CCR7) for evaluating the risk of IA rupture demonstrated good clinical application value.PMID:38538213 | DOI:10.31083/j.jin2303055 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Dan-Dan Xu Xiao-Qiang Liu Zhi-Sheng Wu Source Type: research

Fasting, a Potential Intervention in Alzheimer's Disease
J Integr Neurosci. 2024 Mar 4;23(3):50. doi: 10.31083/j.jin2303050.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder characterized by the onset of symptoms, typically occurring later in life, and significant deficits in cognitive functions including learning, memory, speech, and behavior. Ongoing research endeavors seek to explore methods for preventing and treating AD, as well as delving into the molecular mechanisms underlying existing and novel therapeutic approaches encompassing exercise, diet, and drug regimens for individuals with AD or those at risk of developing AD. Among these interventions, dietary...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Zhengzhong Zeng Hu Zhang Xianping Wang Jiawen Shen Danyang Chen Source Type: research

Netrin-1 Role in Nociceptive Neuron Sprouting through Activation of DCC Signaling in a Rat Model of Bone Cancer Pain
CONCLUSIONS: Netrin-1 may contribute to the activation of the BCP by inducing nociceptive nerve innervation and improving pain behaviors.PMID:38538215 | DOI:10.31083/j.jin2303047 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Zhihao Gong Yuxin Zhang Wei Wang Xin Li Kai Wang Xingji You Jingxiang Wu Source Type: research

Mechanism of Dendrobium Nobile Polysaccharide Inhibition of Ferroptosis in Rats with Spinal Cord Injury
CONCLUSIONS: DNP facilitated the post-injury recovery in SCI rats via the inhibition of ferroptosis.PMID:38538216 | DOI:10.31083/j.jin2303065 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Jian Huang Jianghong Luo Ying Huang Linghong Wang Haibing Zhu Zhengnan Li Jianping Chen Source Type: research

The Genetic Association of MMP-2 Gene Polymorphisms with the Susceptibility to Alzheimer's Disease
CONCLUSIONS: MMP-2 gene rs243866 and rs243865 polymorphisms were closely associated with the onset age of AD. The presence of rs243866 AA genotype emerged as a crucial predictor of AD risk.PMID:38538217 | DOI:10.31083/j.jin2303052 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Lina Liu Luran Liu Yunting Lu Tianyuan Zhang Wenting Zhao Source Type: research

Neuropeptides as Potential Biomarkers in Vascular Dementia
This article reviews recent advances in the involvement of neuropeptides in vascular dementia. Neuropeptides are present in the brain as chemical signals and last for nearly 50 years. Peptide hormones are chemical signals of the endocrine system. Thus, neuropeptides are the most diverse class of signaling molecules in the brain, involving the genomes of many mammals, encoding neuropeptide precursors and many bioactive neuropeptides. Here the aim is to describe the recent advances in classical neuropeptides, as well as putative neuropeptides from other families, in the control of or as diagnostic tools for vascular dementia...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Xue Yan Yihong Ma Limin Yan Simin Li Yuzhen Xu Source Type: research

Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research

Association of Retinal Nerve Fiber Layer Thickness with Brain Microstructural Changes in Participants with White Matter Hyperintensities
CONCLUSIONS: We suggest neurodegeneration of peripapillary RNFL in older adults with WMH was associated with cerebral microstructural volume, impaired cerebral axonal damage, and cognitive performances. OCT metrics may provide evidence of neurodegeneration that may underpin WMH and cerebral microstructural changes in the brain.CLINICAL TRIAL REGISTRATION: This study was registered online at the China Clinical Trial Registration Center (registration number: ChiCTR-ROC-17011819).PMID:38538220 | DOI:10.31083/j.jin2303056 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Yucong Wu Jueyue Yan Lu Xu Chunfei Xu Meiqi Zhao Zhenxiang Zhan Yi Lu Xiaozhen Liu Yungang Cao Zhao Han Source Type: research