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Neuromodulation of Cardiac Ischemic Pain: Role of the Autonomic Nervous System and Vasopressin
J Integr Neurosci. 2024 Mar 1;23(3):49. doi: 10.31083/j.jin2303049.ABSTRACTCardiac pain is an index of cardiac ischemia that helps the detection of cardiac hypoxia and adjustment of activity in the sufferer. Drivers and thresholds of cardiac pain markedly differ in different subjects and can oscillate in the same individual, showing a distinct circadian rhythmicity and clinical picture. In patients with syndrome X or silent ischemia, cardiac pain intensity may cause neurogenic stress that potentiates the cardiac work and intensifies the cardiac hypoxia and discomfort of the patient. The reasons for individual differences i...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Ewa Szczepanska-Sadowska Source Type: research

The Impact of PCSK9 Gene Polymorphisms on Ischemic Stroke: A Systematic Review and Meta-Analysis
CONCLUSIONS: This meta-analysis demonstrated that G allele variant of PCSK9 rs505151 and A allele variant of PCSK9 rs17111503 were associated with an increased risk of IS. Based on our findings, these SNPs could serve as potential targets for the diagnosis and treatment of IS. The integration of information on genetic polymorphism into IS risk prediction model may be beneficial in routine clinical practice.PMID:38538222 | DOI:10.31083/j.jin2303062 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Jianhong Wang Shuang Li Yi Ren Guiquan Wang Weirong Li Source Type: research

Tanshinone IIA Regulates Synaptic Plasticity in Mg 2+ -Free-Induced Epileptic Hippocampal Neurons via the PI3K/Akt Signaling Pathway
CONCLUSIONS: TSIIA was effective in reducing harm to the synaptic plasticity of hippocampal neurons induced by persistent status epilepticus, with the possible mechanism being regulation of the phosphatidylinositol 3-kinase 56 (PI3K)/Akt signaling pathway.PMID:38538223 | DOI:10.31083/j.jin2303061 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Meile Ma Xi Hua Chen Jia Nan Xiao Li Zhang Liming Wei Haisheng Jiao Source Type: research

Optogenetic Inhibition of the Cortical Efferents to the Locus Ceruleus Region of Pontine Tegmentum Causes Cognitive Deficits
CONCLUSIONS: Our results reveal essential long-range regulatory circuits from the mPFC to LC and from LC to the limbic system that serves to optimize cognitive performance.PMID:38538224 | DOI:10.31083/j.jin2303060 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Eugene Dimitrov Source Type: research

Single Session Effects of Prolonged Continuous Theta Burst Stimulation Targeting Two Brain Regions on Pain Perception in Patients with Painful Diabetic Neuropathy: A Preliminary Study
CONCLUSIONS: In pDN patients with NP, our study results demonstrated significant improvement in scores on self-report measures of pain (SRMP) after a single session of pcTBS targeting the M1 and DLPFC brain regions. Future studies should consider utilizing multiple sessions of pcTBS to evaluate its long-term effects on pain perception, safety and tolerability in patients with chronic pain.CLINICAL TRIAL REGISTRATION: This study was registered on the ClinicalTrials.gov website (NCT04988321).PMID:38538225 | DOI:10.31083/j.jin2303054 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Bhushan Thakkar Carrie L Peterson Edmund O Acevedo Source Type: research

Translation from Preclinical Research to Clinical Trials: Brain-Gut Photobiomodulation Therapy for Alzheimer's Disease
This article outlines the translation from the preclinical to clinical stages of an innovative brain-gut PBM therapy in a mouse model of AD, a pilot clinical trial involving mild-to-moderate AD patients, and a continuing pivotal clinical trial with a similar patient population. In a mouse model of AD (Aβ25-35), daily application of brain-gut PBM therapy to both the head and the abdomen produced a neuroprotective effect against the neurotoxic effects of an Aβ25-35 peptide injection by normalizing all the modified behavioral and biochemical parameters. The pilot clinical trial to evaluate brain-gut PBM therapy demonstrated...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Guillaume Blivet Fran çois J Roman Julien Delrieu Jacques Touchon Source Type: research

Harnessing Big Data in Amyotrophic Lateral Sclerosis: Machine Learning Applications for Clinical Practice and Pharmaceutical Trials
J Integr Neurosci. 2024 Mar 18;23(3):58. doi: 10.31083/j.jin2303058.ABSTRACTThe arrival of genotype-specific therapies in amyotrophic lateral sclerosis (ALS) signals the dawn of precision medicine in motor neuron diseases (MNDs). After decades of academic studies in ALS, we are now witnessing tangible clinical advances. An ever increasing number of well-designed descriptive studies have been published in recent years, characterizing typical disease-burden patterns in vivo and post mortem. Phenotype- and genotype-associated traits and "typical" propagation patterns have been described based on longitudinal clinical and biom...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Ee Ling Tan Jasmin Lope Peter Bede Source Type: research

Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research

Self-Modulation of Gamma-Band Synchronization through EEG-Neurofeedback Training in the Elderly
CONCLUSION: The findings of this double-blind study align with a key criterion for successful neuromodulation, highlighting the significant potential of Gamma-band synchronization in such a process. This important outcome encourages further exploration of EEG-neurofeedback on this specific neural biomarker as a promising intervention to counter the cognitive decline that often accompanies brain aging and, eventually, to modify the progression of AD.PMID:38538229 | DOI:10.31083/j.jin2303067 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Katia Andrade Nesma Houmani Thomas Guieysse Solofo Razafimahatratra Andr é Klarsfeld G érard Dreyfus Bruno Dubois Fran çois Vialatte Takfarinas Medani Source Type: research

Blocking Pannexin 1 Channels Alleviates Peripheral Inflammatory Pain but not Paclitaxel-Induced Neuropathy
CONCLUSION: Our findings suggest that Panx1 is critical for developing peripheral inflammatory pain and acute nociception involving transient receptor potential vanilloid subtype 1 (TRPV1) but is not essential for neuropathic pain chronicity.PMID:38538230 | DOI:10.31083/j.jin2303064 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Julia Borges Paes Lemes Kaue Franco Malange Nathalia Santos Carvalho Amanda Ferreira Neves Marcia Urban-Maldonado Paula Regina Gelinski Kempe Catarine Massucato Nishijima Cecilia Costa Fagundes Celina Monteiro da Cruz Lotufo Sylvia Ottile Suadicani Carlos Source Type: research

No Frequency-Specific Effect of Transcranial Random Noise Stimulation on Resting EEG
CONCLUSIONS: These observations suggest that tRNS itself does not target or alter specific EEG frequencies. Rather, tRNS most likely interacts with the cognitive task/activity at hand to produce an observable difference in post-tRNS EEG. Positive tRNS-EEG findings from previous studies are also likely to have resulted from the interactive and cognitive activity-dependent nature of tRNS.PMID:38538231 | DOI:10.31083/j.jin2303059 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Shih-Chiang Ke Yu-Hui Lo Philip Tseng Source Type: research

Properties of the Caudal Pontine Reticular Nucleus Neurons Determine the Acoustic Startle Response in Cntnap2 KO Rats
CONCLUSIONS: Recruitment and size of PnC giant neurons are important factors for regulating the magnitude of the acoustic startle response in Cntnap2-⁣/- rats, particularly in males. These findings allow for a better understanding of increased reactivity to sound in Cntnap2-⁣/- rats and in CNTNAP2-associated disorders such as ASD.PMID:38538232 | DOI:10.31083/j.jin2303063 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Alice Zheng Rajkamalpreet S Mann Dami Solaja Brian L Allman Susanne Schmid Source Type: research

The Neural Mechanism Underlying Differentiated In-Group Versus Out-Group Face Recognition and Memory, Identification, Empathy and Pro-social Behavior: Evidence from fMRI and ERP Studies
J Integr Neurosci. 2024 Mar 1;23(3):48. doi: 10.31083/j.jin2303048.ABSTRACTIn the context of perceiving individuals within and outside of social groups, there are distinct cognitive processes and mechanisms in the brain. Extensive research in recent years has delved into the neural mechanisms that underlie differences in how we perceive individuals from different social groups. To gain a deeper understanding of these neural mechanisms, we present a comprehensive review from the perspectives of facial recognition and memory, intergroup identification, empathy, and pro-social behavior. Specifically, we focus on studies that ...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Kaizhen Peng Lili Tan Xiaomin Zhang Source Type: research

 CD6 and CCR7 as Genetic Biomarkers in Evaluating Intracranial Aneurysm Rupture Risk
CONCLUSIONS: The identified two-gene signature (CD6-CCR7) for evaluating the risk of IA rupture demonstrated good clinical application value.PMID:38538213 | DOI:10.31083/j.jin2303055 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Dan-Dan Xu Xiao-Qiang Liu Zhi-Sheng Wu Source Type: research

Fasting, a Potential Intervention in Alzheimer's Disease
J Integr Neurosci. 2024 Mar 4;23(3):50. doi: 10.31083/j.jin2303050.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder characterized by the onset of symptoms, typically occurring later in life, and significant deficits in cognitive functions including learning, memory, speech, and behavior. Ongoing research endeavors seek to explore methods for preventing and treating AD, as well as delving into the molecular mechanisms underlying existing and novel therapeutic approaches encompassing exercise, diet, and drug regimens for individuals with AD or those at risk of developing AD. Among these interventions, dietary...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Zhengzhong Zeng Hu Zhang Xianping Wang Jiawen Shen Danyang Chen Source Type: research