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Harnessing Big Data in Amyotrophic Lateral Sclerosis: Machine Learning Applications for Clinical Practice and Pharmaceutical Trials
J Integr Neurosci. 2024 Mar 18;23(3):58. doi: 10.31083/j.jin2303058.ABSTRACTThe arrival of genotype-specific therapies in amyotrophic lateral sclerosis (ALS) signals the dawn of precision medicine in motor neuron diseases (MNDs). After decades of academic studies in ALS, we are now witnessing tangible clinical advances. An ever increasing number of well-designed descriptive studies have been published in recent years, characterizing typical disease-burden patterns in vivo and post mortem. Phenotype- and genotype-associated traits and "typical" propagation patterns have been described based on longitudinal clinical and biom...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Ee Ling Tan Jasmin Lope Peter Bede Source Type: research

Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research

Self-Modulation of Gamma-Band Synchronization through EEG-Neurofeedback Training in the Elderly
CONCLUSION: The findings of this double-blind study align with a key criterion for successful neuromodulation, highlighting the significant potential of Gamma-band synchronization in such a process. This important outcome encourages further exploration of EEG-neurofeedback on this specific neural biomarker as a promising intervention to counter the cognitive decline that often accompanies brain aging and, eventually, to modify the progression of AD.PMID:38538229 | DOI:10.31083/j.jin2303067 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Katia Andrade Nesma Houmani Thomas Guieysse Solofo Razafimahatratra Andr é Klarsfeld G érard Dreyfus Bruno Dubois Fran çois Vialatte Takfarinas Medani Source Type: research

Blocking Pannexin 1 Channels Alleviates Peripheral Inflammatory Pain but not Paclitaxel-Induced Neuropathy
CONCLUSION: Our findings suggest that Panx1 is critical for developing peripheral inflammatory pain and acute nociception involving transient receptor potential vanilloid subtype 1 (TRPV1) but is not essential for neuropathic pain chronicity.PMID:38538230 | DOI:10.31083/j.jin2303064 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Julia Borges Paes Lemes Kaue Franco Malange Nathalia Santos Carvalho Amanda Ferreira Neves Marcia Urban-Maldonado Paula Regina Gelinski Kempe Catarine Massucato Nishijima Cecilia Costa Fagundes Celina Monteiro da Cruz Lotufo Sylvia Ottile Suadicani Carlos Source Type: research

No Frequency-Specific Effect of Transcranial Random Noise Stimulation on Resting EEG
CONCLUSIONS: These observations suggest that tRNS itself does not target or alter specific EEG frequencies. Rather, tRNS most likely interacts with the cognitive task/activity at hand to produce an observable difference in post-tRNS EEG. Positive tRNS-EEG findings from previous studies are also likely to have resulted from the interactive and cognitive activity-dependent nature of tRNS.PMID:38538231 | DOI:10.31083/j.jin2303059 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Shih-Chiang Ke Yu-Hui Lo Philip Tseng Source Type: research