Strain Cervical Elastography in Pregnancy: Feasibility Study and Its Usefulness in Prediction of Preterm Birth
AbstractCervix in pregnancy is a biomechanical barrier holding the uterine contents till the time of parturition. The feasibility and reproducibility of assessing cervical tissue stiffness for predicting preterm birth by a standard method using strain cervical elastography were studied here. The prospective study included use of transvaginal strain elastography assessment of cervix at 22 –24 weeks in three regions of interest: (1) Endocervical canal and entire cervix in mid-sagittal plane (2) At the level of external os in cross section and (3) at the level of internal os in cross-sectional plane, with constant pressure...
Source: Journal of Fetal Medicine - June 7, 2018 Category: Perinatology & Neonatology Source Type: research
First-Trimester Contingent Screening for Trisomy 21 by Fetal Nuchal Translucency and Maternal Serum Biomarkers and Maternal Blood Cell-Free DNA Testing
AbstractAnalysis of cell-free DNA in maternal blood has been proposed as a novel screening method for evaluation of aneuploidies. The higher performance of this technique in screening of trisomies compared to all currently available methods would lead to widespread use of this technique in clinical settings. In total, 1,066,829 singleton pregnancies referred to Nilou Clinical Laboratory were screened for chromosomal trisomies during a period of 12 years. First-trimester screening (FTS), Triple and Quad markers of second-trimester screening (STS) as well as integrated results have been obtained from 444,515, 34,984, 560,8...
Source: Journal of Fetal Medicine - June 7, 2018 Category: Perinatology & Neonatology Source Type: research
Non-invasive Prenatal Testing: A Unique Approach with Single Nucleotide Polymorphism
AbstractThe purpose of this review is to demonstrate the unique properties of a single nucleotide polymorphism (SNP)-based approach in non-invasive prenatal testing (NIPT). The identification of cell free fetal DNA in the plasma of pregnant women led to the development of NIPT. This can be performed with either a quantitative approach (massively parallel shotgun sequencing, chromosome selective sequencing) or a qualitative approach (SNP-based). NIPT tests have been shown to have superior performance as a screen for common fetal chromosome abnormalities compared with maternal serum screening. At low fetal fractions, NIPT se...
Source: Journal of Fetal Medicine - June 1, 2018 Category: Perinatology & Neonatology Source Type: research
Idiopathic Arterial Calcification: Experience from a Single Center in South India
Abstract Idiopathic arterial calcification of infancy is a rare autosomal recessive disease, characterized by deposition of calcium along the internal elastic membrane of arteries, accompanied by fibrous thickening of the intima which causes luminal narrowing. We hereby report a series of 20 cases seen over a period of 10 years. Nineteen cases were reported as idiopathic arterial calcification and one was reported as arterial calcification in a twin reversed arterial perfusion sequence. The sites of calcification were mainly aortic valve and root of aorta which was involved in 100% of case s followed by pulmonary artery...
Source: Journal of Fetal Medicine - May 29, 2018 Category: Perinatology & Neonatology Source Type: research
Giant Congenital Intracranial Immature Teratoma: A Case Report and Review of Literature
We presented a case of giant fetal intracranial tumour diagnosed antenatally at 28 weeks of gestation in sonography. The magnetic resonance imaging confirmed a large hetrogenous intracran ial mass with bilateral ventriculomegaly. Because of the large size of the tumor and associated macrocephaly, the baby was delivered by caessaran section. On delivery, fetal head size was 44.5 cm with wide suture and left facial nerve was involved. Ventriculoeritoneal shunt was inserted on 4th pos tnatal day, however complete surgical resection of tumour was not performed because of parents refusal. Neonate had rapid increase in head s...
Source: Journal of Fetal Medicine - May 24, 2018 Category: Perinatology & Neonatology Source Type: research
Thanatophoric Dysplasia and the Brain —A Perinatal Pathology Study
AbstractThe purpose of this article is to analyse all cases of thanatophoric dysplasia and document the associated CNS anomalies. A retrospective study of all cases of thanatophoric dysplasia diagnosed in the department of perinatal pathology from January 2009 to December 2016. The various associated findings with due reference to the CNS manifestations were analyzed. During the study period, 7741 foetal autopsies were done, of which 24 (0.31%) were diagnosed to have thanatophoric dysplasia. The brain of one case was autolysed and hence, this had been excluded from this study. Of the 23 cases, 19 were of type 1 (83%) and...
Source: Journal of Fetal Medicine - May 23, 2018 Category: Perinatology & Neonatology Source Type: research
Early Second-Trimester Spontaneous Miscarriage Due to Fourth Ventricle Choroid Plexus Papilloma
AbstractMiscarriage due to fetal tumors is an extremely rare finding, with a varying incidence from 1.7 to 13.5 per 100,000 live births, with central nervous system tumors occupying a minority of these cases. Herein, we report the gross morphological and histological findings of a 17-gestational week spontaneous miscarriage in a 27 year old multi-gravida due to a fourth ventricle choroid plexus papilloma (CPP). The CPP was composed of a pronoun fibro-vascular stroma covered with a dense lining of tall cuboid sparsely ciliated single cell layer with rich in chromatin nuclei. The cytoplasm of the CPP covering cells was int...
Source: Journal of Fetal Medicine - May 16, 2018 Category: Perinatology & Neonatology Source Type: research
Sonographic Evaluation of Umbilical Vein
AbstractTo evaluate intraabdominal course of umbilical vein, its relation with portal vein and ductus venosus and its anomalies. All pregnant women were examined during midtrimester anomaly scan between January 2015 and December 2017. With evaluation of umbilical vein in its intraabdominal course, size of umbilical vein, its relation to the stomach and the gallbladder and origin of ductus venosus were studied in middle and upper abdominal axial and sagittal planes by two dimensional and colour doppler sonography. Anastomosis of umbilical vein with portal vein and its further course was examined and detailed anatomical surv...
Source: Journal of Fetal Medicine - May 10, 2018 Category: Perinatology & Neonatology Source Type: research
Rupture of Non-communicating Rudimentary Horn of Unicornuate Uterus with Pregnancy
We describe a case which presented with the rupture of non-communicating horn with live fetus inside it. The present case had a 22 week fetus floating in the peritoneal cavity following the rupture of non-communicating horn with normal other uterine horn. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - May 8, 2018 Category: Perinatology & Neonatology Source Type: research
Prenatal Diagnosis of Isolated Redundant Foramen Ovale: A Case Report
Abstract
Redundant foramen ovale (RFO) is defined as an abnormally redundant foramen ovale flap that extends at least halfway across the left atrium. The exact pathogenesis is unknown. Premature, isolated, in utero RFO is rare. The prevalence in general population is unknown as it may be easily ignored on routine fetal echocardiography. The reported frequency in fetuses referred for echocardiographic examination is 0.6 –1.7%. It can cause right ventricular volume overload leading to fetal hydrops and subsequent cardiac failure. In such cases, prompt delivery depending on fetal gestational age may be instrumental for t...
Source: Journal of Fetal Medicine - May 2, 2018 Category: Perinatology & Neonatology Source Type: research
Prenatal Diagnosis of Aberrant Right Subclavian Artery in Unselected North Indian Population: Significance and Counselling
This study was carried out to assess the incidence and association of aberrant right subclavian artery in North Indian population and to analyse its significance as a marker of Down syndrome and to formulate an adaptable protocol for counselling and management of such pregnancies. A prospective assessment of 1024 consecutive unselected pregnancies with gestational age between 12 and 34 weeks was carried out from May 2016 to August 2017 at the author’s fetal medicine centre in North India. The screening for ARSA was performed with Color Doppler using low PRF at 3 vessel trachea view in axial section followed by confirmi...
Source: Journal of Fetal Medicine - April 16, 2018 Category: Perinatology & Neonatology Source Type: research
The Year Gone By: SFM Academic Activities 2017
(Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - April 10, 2018 Category: Perinatology & Neonatology Source Type: research
Non-invasive Prenatal Testing: A Unique Approach with Single Nucleotide Polymorphism
AbstractThe purpose of this review is to demonstrate the unique properties of a single nucleotide polymorphism (SNP)-based approach in non-invasive prenatal testing (NIPT). The identification of cell free fetal DNA in the plasma of pregnant women led to the development of NIPT. This can be performed with either a quantitative approach (massively parallel shotgun sequencing, chromosome selective sequencing) or a qualitative approach (SNP-based). NIPT tests have been shown to have superior performance as a screen for common fetal chromosome abnormalities compared with maternal serum screening. At low fetal fractions, NIPT se...
Source: Journal of Fetal Medicine - April 10, 2018 Category: Perinatology & Neonatology Source Type: research
Achievements in 2017, Promises of 2018
(Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - April 4, 2018 Category: Perinatology & Neonatology Source Type: research
Congenital Pouch Colon: A Case Report
We report the antenatal sonographic findings of a boy found to have CPC type I postnatally, which was suspected to be an anorectal malformation in utero. This entity has been described in the literature mainly from the Indian subcontinent. Therefore, it is an important differential diagnosis to be kept in mind in fetuses with abnormal large bowel pattern. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - March 13, 2018 Category: Perinatology & Neonatology Source Type: research
