Management of Isolated Fetal Lymphangiomas Following Prenatal Diagnosis: Case Series
We report three cases of isolated fetal cystic hygromas diagnosed prenatally at various gestations. Two were of moderate size over the anterolateral aspect of the neck and one case had a huge lymphangioma involving the entire right side of the chest wall. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - February 15, 2021 Category: Perinatology & Neonatology Source Type: research

‘TRAP-ped with an Acardius’: Case Series of Twin Reversed Arterial Perfusion (TRAP) Sequence and Review of Literature
We report four cases of TRAP sequence treated in our institutions and supply an overview on currently existing literature. This case series demonstrates the heterogeneity in manifestations and clinical course of patients affected by this condition. Furthermore, it includes an acardius amorphous of considerable size delivered at 35.6  weeks of gestation. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - February 8, 2021 Category: Perinatology & Neonatology Source Type: research

Clinical Profile of Women with Congenital Fetal Malformations: A Retrospective Cohort Study
ConclusionThe most common anomalies were CNS and majority were primigravidae. The most common medical disorder associated was diabetes. It is possible that they are deficient in folic acid and vitamin B12. Hence pre-conceptional control of medical disorders, nutritional counselling regarding intake of micronutrients and awareness programmes to take pre-conceptional folic acid and vitamin B12 are the need of the hour for prevention. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - January 20, 2021 Category: Perinatology & Neonatology Source Type: research

Prenatal Diagnosis of Agnathia/Otocephaly: Associations and Outcomes-Large Case Series and Review of Literature
We present 26 cases of prenatally diagnosed agnathia/otocephaly, the largest published series so far, with a broad review of available literature and updated concepts on the etiopathogenesis. This is a retrospective case series identified between May 2000 and April 2018 in a tertiary fetal medicine centre in South India where we evaluated the ultrasound features of agnathia/ otocephaly and assessed the associated anomalies and syndromes. Out of 26 cases identified, 42% were isolated and 58% were associated with other anomalies. The most common associations were skeletal (7) followed by central nervous system anomalies (4) ...
Source: Journal of Fetal Medicine - January 19, 2021 Category: Perinatology & Neonatology Source Type: research

Prenatal Sonographic and MRI Assessment of Early Fetal Neck Immature Teratoma
We report a case of a pregnancy involving a  fetal neck mass which was diagnosed at 19 weeks of gestation. Three dimensional ultrasound provided detailed additional information about the extent of the lesion and the areas of involvement. Color Doppler revealed intense vascularity within the lesion, with both arterial and venous flow. Fetal MRI revealed the exact extent of the lesion along with deep seated structures involved. Diffusion weighted images revealed restricted diffusion with low ADC values suggesting a mitotic etiology. The patient along with her husband decided to abort the fetus. An infantogram of th...
Source: Journal of Fetal Medicine - January 11, 2021 Category: Perinatology & Neonatology Source Type: research

Retrograde Flow in the  Aortic Isthmus: Trigger to Deliver Growth Restricted Fetuses Between 30 and 34 Weeks of Gestation?
ConclusionRetrograde blood flow in the  AoI is associated with adverse perinatal outcome, particularly intrauterine fetal demise, neonatal death, Respiratory Distress Syndrome (RDS) and increased duration of Neonatal Intensive Care Unit (NICU) stay. Even if DV flow is normal, adverse outcome might be suspected in fetuses with AEDF/RED F in the UA and retrograde flow in the AoI. Consequently, retrograde flow in the AoI might be considered as an additional trigger for delivering FGR fetuses at 30–34 weeks with AREDF in the UA. Larger longitudinal studies are, however, requir...
Source: Journal of Fetal Medicine - January 6, 2021 Category: Perinatology & Neonatology Source Type: research

Interstitial Laser Occlusion of the Systemic Feeding Vessel in a Hybrid Lung Lesion: Technique, Clinical Course, Perinatal Outcome and a Review of Literature
We describe a case of a hybrid CPAM complicated by hydrops which was successfully treated by interstitial laser coagulation of the systemic feeder artery. We also review current literature on the available interventions and conclude that interstitial laser has emerged as the preferred modali ty of treatment over the years. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - January 3, 2021 Category: Perinatology & Neonatology Source Type: research

Prenatal Binder Phenotype: Physician ’s Dilemma-A Case Report
AbstractThe  Binder phenotype is defined by midface hypoplasia, underdeveloped frontal sinuses, hypoplastic and abnormally positioned nasal bones, nostrils appearing moon or comma-shaped and prognathism. It is heterogeneous in etiology and not fully understood. Multiple causative factors are describe d. The physician’s dilemma is of diagnosing the fetal abnormalities on antenatal ultrasound for which there is no confirmatory testing. There are management and ethical problems regarding the diagnosis, further investigations and confirmation of the diagnosis. The Binder phenotype...
Source: Journal of Fetal Medicine - January 3, 2021 Category: Perinatology & Neonatology Source Type: research

Surgical Removal of a Gigantic Retroperitoneal Fetus in Fetu: One Case Report
AbstractFetus in fetu (FIF) is a rare congenital disorder. At present, the mechanism of FIF has not been fully elucidated. Clinically, the most common site of FIF is the abdominal cavity, while other sites have also been reported, such as from the scrotum to the intracranial space. Surgery is the best treatment for FIF. Our case is a 1-month-old girl. The mother ’s ultrasound examination at 36 weeks of gestation revealed that the solid part of the abdominal mass showed strong echoes of the limbs, and the fetus was about 40 mm long. The diagnosis was a parasitic fetus in the fetus. The child was admitted to ...
Source: Journal of Fetal Medicine - January 2, 2021 Category: Perinatology & Neonatology Source Type: research

Size and Volume Charts for Fetal Adrenal Gland: A Prospective Study in Indian Population
AbstractThe  fetal adrenal gland plays a pivotal role in perinatal survival. Because imaging the fetal adrenal gland is not part of routine antenatal ultrasonography (US), there is a paucity of available data about imaging techniques. The purpose of this study was to construct gestational age-wise data for f etal adrenal gland size and volume (2D US measurements) for 20, 21, 22 and 32 weeks of gestation and define a technique to measure the gland ultrasonographically. One year prospective study, at a single centre. 87 consecutive pregnant women with uncomplicated singleton pregnancy were inclu...
Source: Journal of Fetal Medicine - January 2, 2021 Category: Perinatology & Neonatology Source Type: research

Prenatal Diagnosis of Absent Right Superior Vena Cava in Referrals for Fetal Echocardiography
We present 14 patients with a prenatal diagnosis of single LSVC and situs solitus, including prenatal findings and information on medium-term follow-up. We identified patients with situs solitus and a persistent LSVC born between March 2004 and March 2020, which had been diagnosed prenatally between December 2003 and November 2019. From this cohort, we identified those with absent RSVC. In the population of women undergoing fetal echocardiography, the prevalence of persistent LSVC in situs solitus was 0.43% (84/19,712). For the 84 identified patients and for the entire population respectively, 14/84 (17%) and 14/19,712 (0....
Source: Journal of Fetal Medicine - January 1, 2021 Category: Perinatology & Neonatology Source Type: research

Antenatal Diagnosis of Filar Cysts: An Ultrasound Study of 2 Cases
We report 2 cases of cysts of filum terminale (filar cysts) diagnosed antenatally in the second trimester (19 weeks and 22 weeks of gestation respectively). (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - December 29, 2020 Category: Perinatology & Neonatology Source Type: research

Prenatal Diagnosis of Bardet-Biedl Syndrome: A Case Study and Review of Literature
We present a case of Bardet-Biedl syndrome diagnosed prenatally at 18 weeks gestation based on prenatal ultrasound findings of post axial polydactyly with bilateral hyperechogenic kidneys. Clinica l suspicion based on ultrasound findings was supplemented amniocentesis and clinical exome sequencing. This showed a  pathogenic variant in homozygous state in theMKKS gene, consistent with Bardet-Biedl syndrome type 6. Unless BBS has been suspected antenatally, diagnosis of BBS is usually made in late childhood or early adulthood adding to the psychological, emotional and financial burden on the family. With advances i...
Source: Journal of Fetal Medicine - December 28, 2020 Category: Perinatology & Neonatology Source Type: research

Anticancer Agent Gefitinib and Congenital Anomalies
We report the  first case of multiple anomalies associated with antenatal exposure to the anticancer agent Gefitinib. The patient conceived while she was on tablet Gefitinib 250 mg once a day for stage IV adenocarcinoma of lungs. The first scan done at 29 weeks 2 days showed liquor amnii on the upper limit of normal, single umbilical artery, left sided congenital diaphragmatic hernia, ventriculoseptal defect and left radial ray defect. The patient had a preterm delivery after one week and she refused autopsy. It is important to advise patients regarding contraception while undergoing chem...
Source: Journal of Fetal Medicine - December 28, 2020 Category: Perinatology & Neonatology Source Type: research

Ultrasound Guided Intrasac Methotrexate Instillation for Live Cesarean Scar Ectopic Pregnancy
AbstractA 38-year-old G5P2 with previous 2LSCS, 2D&Cs and hysteroscopic myomectomy presented with a live Cesarean scar ectopic of 7  weeks gestation. Transabdominal ultrasound-guided intrasac potassium chloride and methotrexate instillation was performed under local anesthesia leading to a successful resolution of the ectopic pregnancy. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - December 5, 2020 Category: Perinatology & Neonatology Source Type: research

Unusual Combination of Anomalous Connection of the Left Pulmonary Veins and Aortic Arch Anomaly Presenting as Abnormal Three Vessel View in the 2nd Trimester US Scan
AbstractPartial anomalous pulmonary venous drainage is often missed antenatally unless a complex congenital heart defect is associated. Likewise, isolated fetal coarctation of aorta has only a  60–70% chance to be diagnosed in the second trimester. The combination of these two conditions (PAPVC and COA), in the absence of situs abnormality or syndromic association is rare and not much reported in the literature. We are reporting a fetal heart which presented with apparent hypoplasia o f the left ventricle and ascending aorta, as well as significant dilatation of the right atrium, right ventricle and pu...
Source: Journal of Fetal Medicine - November 27, 2020 Category: Perinatology & Neonatology Source Type: research

Diagnostic Value of Ultrasonography and MR in Antenatal Diagnosis of Placenta Accreta Spectrum
AbstractThe aim of this study was to compare the accuracy of ultrasonography and magnetic resonance imaging (MR)  in the antenatal diagnosis of placenta accreta. We also determined the most relevant sonographic and MR features associated with the diagnosis of placenta accreta. In a prospective observational study approved by the Ethical Board of the Radiology Department, 109 pregnant women who were at high ri sk for Placenta Accreta were enrolled. The placentas of all cases were scanned using both gray-scale and color Doppler transabdominal sonography. MR was performed when sonographic findings were equivocal &nb...
Source: Journal of Fetal Medicine - November 19, 2020 Category: Perinatology & Neonatology Source Type: research

Cyst of the Filum Terminale: Potpourri of 3 Prenatally Diagnosed Cases
We report three cases of a FT cyst diagnosed prenatally. The objective of reporting these is to make clinicians aware of the importance of the relevance of this clinical entity. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - November 19, 2020 Category: Perinatology & Neonatology Source Type: research

Chorioangioma: A Case Report
We report a case of large Chorioangioma managed conservatively. Early diagnosis was made, patient counseling followed by close surveillance with Doppler, MCA PSV was done for fetal wellbeing. The timely intervention led to good neonatal and maternal outcome aided with NICU management. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - October 31, 2020 Category: Perinatology & Neonatology Source Type: research

Unusual Presentations of Trisomy 21
We present 2 cases which had abnormalities which are very rarely associated with Down ’s syndrome. In the first case, the patient had bilateral congenital cataract along with an absent nasal bone. In the second case, the patient had severe asymmetric fetal growth restriction at 20 weeks with other multi-system abnormalities. With detailed ultrasound scanning and thorough investi gation, we could diagnose trisomy 21 even with such unusual presentations. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - October 5, 2020 Category: Perinatology & Neonatology Source Type: research

Hyperechogenic Fetal Kidneys: Uncertain Diagnosis and Unpredictable Future?
AbstractGlomerulocystic kidney with increased renal echogenicity encompasses a number of renal abnormalities that might have cystic glomeruli and be a sequelae of  renal obstruction. Increased echogenicity of the kidneys is a non-specific finding and a result of varied etiologies. Multiple microscopic cortical and medullary cysts, interstitial fibrosis and mesangial sclerosis are the etiopathogenesis for renal hyperechogenicity even in the absence of macrocy sts. The crucial point is poor predictability of antenatal ultrasound to fully define the extent and severity of parenchymal damage and to forecast its outco...
Source: Journal of Fetal Medicine - September 17, 2020 Category: Perinatology & Neonatology Source Type: research

A Novel Co-occurrence of VACTERL and Closed Neural Tube Defect
We present a case with 4 components of the association—single umbilical artery, an orectal malformation, unilateral renal agenesis and limb abnormalities. There was also a closed neural tube defect-lipomyelomeningocele with tethered cord. The presence of a neural tube defect with VACTERL makes  this a unique case since the reported vertebral anomalies in VACTERL are non dysra phic. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - September 15, 2020 Category: Perinatology & Neonatology Source Type: research

Prenatal Diagnosis of Right Sided Inguinoscrotal Hernia Associated with Severe Growth Restriction in a Fetus with Trisomy 18: A Case Report
We present a case of prenatal diagnosis of right sided fetal inguinoscrotal hernia, with contralateral hydrocele and severe fetal growth restriction confirmed as Trisomy 18 in subsequently performed chromosomal analysis. The index case presented at 35+2 weeks of gestation with a right sided solid scrotal mass with a  regular contour, mixed echogenic texture with a few echo-free areas, a distinctive arterial supply and characteristic peristaltic movements. Fetal demise was noted  one week later. The diagnosis was confirmed by postnatal examination. Prenatal diagnosis of fetal inguinoscrota...
Source: Journal of Fetal Medicine - September 11, 2020 Category: Perinatology & Neonatology Source Type: research

Diagnosis and Management of Fetal Ductus Arteriosus Constriction
We present a series of ductus arteriosus constriction, of which 3 cases were associated with tricuspid regurgitation, 1 case with right sided dominance of the heart and 1 case with moderate to severe right ventricular hypertrophy. Mild cases require close fetal monitoring and severe cases may need urgent delivery. Postnatal prognosis seems to be good in cases of ductal constriction associated with right heart abnormalities as right heart abnormalities resolve in a couple of weeks, although pulmonary hypertension and right ventricular failure are major concerns. P reventive measures include avoiding...
Source: Journal of Fetal Medicine - September 1, 2020 Category: Perinatology & Neonatology Source Type: research

Importance of Analysis of Arrhythmia Mechanism in Predicting Outcomes in Fetal Bradycardia: A Single-Centre Retrospective Study from a Dedicated Fetal Cardiology Unit in South India
This study aimed to correlate the  arrhythmia mechanism to pregnancy and early postnatal outcomes in fetal bradycardia. This was retrospective study (May 2013–November 2019). Fetuses with sustained bradycardia (heart rate ≤ 100 per minute) were included. Based on arrhythmia mechanism, patients were categorized into 4 group s:Group 1: blocked atrial ectopics, Group 2: second-degree atrioventricular block (AVB), Group 3: complete AVB and group 4: sinus bradycardia. Clinical presentation, need for transplacental therapy, pregnancy and early postnatal outcomes were analysed. A total of&nbs...
Source: Journal of Fetal Medicine - August 26, 2020 Category: Perinatology & Neonatology Source Type: research

First Trimester Ultrasound Evaluation of the Cleft Palate: Midsagittal, Axial or Coronal View-Which View is Best?
ConclusionA combination of all three planes can be used as an effective screening tool but the axial view has more potential for detection of CP in first trimester. However, large scale prospective studies are needed to confirm this observation. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - August 19, 2020 Category: Perinatology & Neonatology Source Type: research

Signal Ambiguity and Misinterpretation of Fetal Heart Rate: A Report of Two Cases and an Overview of Suspicious Patterns
We present two cases where  the Maternal Heart Rate (MHR) artefacts were mistaken for Fetal Heart Rate (FHR). In the first case, MHR masked the severity of fetal distress and caused a delayed and inappropriate management with subsequent poor neonatal outcome. In the second case, MHR was misinterpreted as FHR causing embarra ssment of the birth attendants upon delivery of a dead macerated newborn. FHR should initially and continuously be verified as the actual origin of the signal displayed on the EFHM before any intervention is undertaken. Understanding the EFHM patterns produced by FHR or MHR and the utilization...
Source: Journal of Fetal Medicine - August 16, 2020 Category: Perinatology & Neonatology Source Type: research

Can the Severity of Intrahepatic Cholestasis of Pregnancy be Predicted by Second Trimester Screening Test Parameters?
AbstractObjectiveThe second trimester triple test although declared inadequate for the screening of aneuploidies by the International Society for Prenatal Diagnosis remains a widely employed test. We aim to investigate the associations between the biochemical parameters of the triple test and the severity of intrahepatic cholestasis of pregnancy (ICP).Material and MethodsThe triple test parameters of 102 healthy pregnant women and 100 pregnant women with ICP were evaluated retrospectively. Serum bile acid level of ≥ 40 µmol/L was categorized as severe ICP. Serum α-fetoprotein (AFP), β-human ...
Source: Journal of Fetal Medicine - August 13, 2020 Category: Perinatology & Neonatology Source Type: research

Diagnosis of Infections in Fetus: Ultrasound and Invasive Techniques
AbstractInfections in pregnancy may lead to fetal morbidity and mortality. The major infections which can be transmitted from the mother to the fetus and can probably result in adverse consequences in the prenatal period include toxoplasmosis, rubella, cytomegalovirus (CMV), syphilis, parvovirus, and varicella. Factors determining the risks of transplacental transmission and associated fetal adverse events include the period of gestation at which transmission occurs and the  immunity status of the mother. No single modality can diagnose all fetal infections and consequently prenatal diagnosis of fetal manifestati...
Source: Journal of Fetal Medicine - July 31, 2020 Category: Perinatology & Neonatology Source Type: research

First Trimester Diagnosis of Radial Ray Anomaly
(Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - June 12, 2020 Category: Perinatology & Neonatology Source Type: research

Sonographic Assessment of Fetal Neck Circumference (NC) As a Predictor of Gestational Age
ConclusionThis study derived nomogram for ultrasound measurement of fetal NC in a Northern Nigerian population. However, NC values from this study differ less with an African population than with Caucasian study population. (Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - June 12, 2020 Category: Perinatology & Neonatology Source Type: research

Umbilical Artery Doppler Indices at the Perivesical Segment in Growth-Restricted Fetuses
AbstractTo compare perinatal outcomes of growth-restricted fetuses with bilateral positive end-diastolic (PED) flow at the perivesical segment (PVC) and growth-restricted fetuses with unilateral or bilateral absent/reverse end-diastolic (ARED) flow at the PVC segment. A total of 119 growth-restricted fetuses with PED flow at the free loop of the umbilical artery were enrolled in this cross-sectional study. Methods The patients were separated into three groups according to presence or absence of the end-diastolic flow at the perivesical segment. Patients with bilateral PED flow at the PVC segment were enrolled in Group1, pa...
Source: Journal of Fetal Medicine - June 12, 2020 Category: Perinatology & Neonatology Source Type: research

Intraventricular Hemorrhage in a Single Fetus of Dichorionic-Diamniotic Gestation: A Case Report and Review of Literature
We report the first case of IVH in a fetus of dichorionic-diamniotic pregnancy that worsened postnatally. Antenatally, magnetic resonance imaging confirmed a large IVH after ventricular abnormalities were detected by prenatal ultrasound (US). At birth, a grade IV IVH diagnosis was made and progressive ventricle dilatation was noted on weekly US. A ventriculoperitoneal shunt was placed and ventricle dilatation was slightly reduced, however, the IVH was essentially unchanged. The infant was discharged in stable condition at 12-weeks-old and chronic neurological dysfunction is expected. IVH is seen in complicated births of pr...
Source: Journal of Fetal Medicine - May 1, 2020 Category: Perinatology & Neonatology Source Type: research

Referral Pattern for Fetal Echocardiography Over 10 Years in a Single Fetal Imaging Centre from Southern India
AbstractAimTo study the trend in referral patterns for fetal echocardiography (FE) and the outcomeMethodsRetrospective study of fetuses referred to a single fetal imaging center for FE from Jan 2008 to Dec 2017. The  study group was divided into group 1 (2008–2012) and group 2 (2013–2017). Indications were categorized into ‘low-risk’, ‘maternal-risk’ and ‘fetal-risk’. Detection of cardiac defect (CHD) was noted as abnormal outcome and it was analysed in relation to the referral indication.ResultsThe  study group had 32,679 cases, 11,468 in group 1 and 21,211 in grou...
Source: Journal of Fetal Medicine - April 29, 2020 Category: Perinatology & Neonatology Source Type: research

SFM India Oriented Guidelines for Ultrasound Establishments During the COVID 19 Pandemic
(Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - April 10, 2020 Category: Perinatology & Neonatology Source Type: research

Open Neural Tube Defect in a Fetus with MURCS Association: Value Addition of Fetal Autopsy in Counseling
(Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - April 9, 2020 Category: Perinatology & Neonatology Source Type: research

Outcome of Aneurysmal Septum Primum with Non-restrictive Foramen Ovale in Fetuses with Structurally Normal Hearts: A Tertiary Center Experience
We presented twenty-four cases which also had postnatal echocardiographic examination in our hospital. A t the time of diagnosis of ASP, the mean maternal age was 31.1 ± 5.7 years, the mean gestational age was 28.9 ± 5.9 weeks, the mean birth week was 37.4 ± 3.1 weeks, and the mean birth weight was 2940.8 ± 736.6 g. The postnatal first 3 months prevalences of atrial septal ane urysm, patent foramen ovale and, secundum atrial septal defect (ASD) were 12.5%, 12.5%, 20.8% among fetuses with ASP, respectively. ASP ...
Source: Journal of Fetal Medicine - March 30, 2020 Category: Perinatology & Neonatology Source Type: research

Outcome of Fetuses with Cavum Velum Interpositi Cyst —Experience of a Tertiary Centre
AbstractCavum velum interpositi is the space between the layers of the tela choroidea of the third ventricle. This space occasionally appears as an anechoic lesion in routine  mid-trimester targeted scans because of the presence of fluid inside. This is then called a cavum velum interpositi (CVI) cyst. CVI cyst is a rare finding with varied outcomes. Councellings management are consequently confusing. This study was aimed at assessing the outcome of CVI cysts to g uide the treating clinician and address apprehensions of the expecting couple. Genetic evaluation and MRI to pr...
Source: Journal of Fetal Medicine - March 25, 2020 Category: Perinatology & Neonatology Source Type: research

Intrauterine Fetal Infections: Do-Able Approaches
(Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - March 24, 2020 Category: Perinatology & Neonatology Source Type: research

From Baby Steps to Giant Leaps: A Surprisingly Short Journey
(Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - March 24, 2020 Category: Perinatology & Neonatology Source Type: research

Agenesis of Ductus Venosus: A Case Series
AbstractDuctus venosus agenesis is a rare anomaly which is significantly associated with cardiac, extracardiac and chromosomal anomalies. The prognosis depends on its association with other congenital abnormalities independent of the type of shunt. The aim of this study was to evaluate the ductus venosus in 2nd trimester scans and to  evaluate associated congenital malformations associated with agenesis of the ductus venosus and its feto-neonatal outcome. We performed a retrospective study for a 5 year period from November 2015 to November 2019. Of the 8 cases seen, 2 (25%) had an intrahepatic...
Source: Journal of Fetal Medicine - March 22, 2020 Category: Perinatology & Neonatology Source Type: research

Role of Antenatal Intervention and Pregnancy Outcome in Large Chorioangiomas
AbstractChorioangioma is a non-trophoblastic  benign vascular tumour of the placenta affecting fetal outcome. It has no malignant potential. It is usually diagnosed during the 2nd trimester. These are usually found on the fetal side of the placenta, close to the umbilical cord insertion site protruding into the amniotic cavity. Chorioangi omas can be small or large. Small tumours (less than 5 cm) usually have favourable outcome. Large chorioangiomas (more than 5 cm) usually have an unfavourable outcome and may cause maternal complications like pre-eclampsia, ...
Source: Journal of Fetal Medicine - March 22, 2020 Category: Perinatology & Neonatology Source Type: research

Recent Advances in the Noninvasive Prenatal Testing for Chromosomal Abnormalities Using Maternal Plasma DNA
AbstractNo single invention in the past has created such a rapid and massive impact on clinical obstetric practice as the introduction of noninvasive prenatal screening (NIPS) for chromosomal abnormalities using cell-free DNA in maternal plasma. However, the technology of NIPS which has also been called noninvasive prenatal testing (NIPT) is rapidly evolving. Most clinicians may not be able to fully understand this new technology to enable good clinical practice. This review will be focused on issues that have important clinical implications. NIPT/S is only a screening test and all positive cases must be confirmed by invas...
Source: Journal of Fetal Medicine - March 4, 2020 Category: Perinatology & Neonatology Source Type: research

Change of Editor-in-Chief
(Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - February 25, 2020 Category: Perinatology & Neonatology Source Type: research

The Role of First Trimester Ultrasonography in Antenatal Care: A Study from a Single Perinatal Institute in India
AbstractThe aim of this study was to assess the role of  ultrasound in first the trimester of pregnancy for confirmation of pregnancy, number of fetuses, chorionicity, amnionicity if multiples, viability, assessment of gestational age, identification of structural anomalies and assessment of risk for chromosomal abnormalities. This was a prospective o bservational study. All pregnant women registered within 13+6 weeks were  offered a routine scan between 11+0 and 13+6 weeks. All scans were  done by obstetricians, fetal medicine specialists or radiologists are accredited by the Fetal Medic...
Source: Journal of Fetal Medicine - February 21, 2020 Category: Perinatology & Neonatology Source Type: research

Syphilis in Pregnancy
AbstractSyphilis is a sexually transmitted bacterial disease relevant to pregnancy because it has the potential to cause congenital syphilis if it occurs at any time during pregnancy. An upsurge in cases of syphilis in women and hence congenital syphilis has been reported worldwide recently. 40% of cases can result in spontaneous miscarriages, stillbirth, non-immune hydrops, fetal growth restriction and perinatal death, as well as serious sequelae in liveborn infected children. Pregnancy complications can be avoided by early detection and treatment in the antenatal period. All antenatal women should be screened for syphili...
Source: Journal of Fetal Medicine - February 20, 2020 Category: Perinatology & Neonatology Source Type: research

Chickenpox in Pregnancy
AbstractPregnant women in the tropics like India are more susceptible to varicella zoster infection due to the lower seroprevalence of varicella as compared to temperate regions. Seronegative pregnant women are highly susceptible following a significant exposure owing to the high secondary attack rate of the virus. Fetal transmission could happen transplacentally while neonatal transmission occurs through close contact post partum. Maternal VZV infection could be severe (particularly varicella pneumonia) with high mortality if untreated. Congenital varicella syndrome has an incidence of about 1 –2% and is more likely...
Source: Journal of Fetal Medicine - February 17, 2020 Category: Perinatology & Neonatology Source Type: research

Prospective Comparative Evaluation of Performance of Fetal Growth Charts in the Diagnosis of Suboptimal Fetal Growth During Third Trimester Ultrasound Examination in an Unselected South Indian Antenatal Population
AbstractGrowth standards are key tools in assigning fetal smallness. Growth charts are central to this.  The availability of growth charts with varying conceptual methodology and design makes their comparison imperative to ensure wise clinical decision making. This was a prospective, descriptive and correlational study performed at two fetal medicine centers, on 1019 unselected third trimester South Indian women with singleton pregnancies. The estimated fetal weight (EFW) was calculated from one dataset per woman using the Hadlock III formula. The EFW centiles were obtained from eight prenatal growth charts:...
Source: Journal of Fetal Medicine - February 14, 2020 Category: Perinatology & Neonatology Source Type: research

Normally Grown Non-dysmorphic Stillbirth Post 38 Weeks Gestation and Reduced Fetal Movements: A Matter of Reserve? A Retrospective Study
This study investigates the relationship between placental weight relative to birthweight and risk of stillbirth in non-dysmorphic fetuses  ≥ 38 weeks gestation with no evidence of intrauterine growth restriction. This is a retrospective study of stillbirths who underwent post-mortem between 1st Jan 2011 and 31st Dec 2018 in South East Scotland (n = 55). The control group (n = 74) was matched for gestation, age of mother and maternal BMI. There was a significant difference (p = 0.0117) in the mean ratio of birth weight to placental weight (BW:PW) between the s...
Source: Journal of Fetal Medicine - February 5, 2020 Category: Perinatology & Neonatology Source Type: research

Cytomegalovirus in Pregnancy
AbstractHuman cytomegalovirus is worldwide the most common pathogen causing teratogenic congenital infection. Maternal cytomegalovirus (CMV) infection is a serious health concern as it is associated with severe birth defects like sensori-neural hearing loss, impairment of cognitive development and cerebral palsy. It is acquired by contact with body fluids and by vertical transmission from mother to fetus. Transmission rates are particularly high after primary infection of women. Unlike rubella infection, past infection with CMV and seropositivity at the  time of conception does not confer protection to the fetus. The ...
Source: Journal of Fetal Medicine - January 28, 2020 Category: Perinatology & Neonatology Source Type: research