Retraction Note: MicroRNA-338-3p suppresses ovarian cancer cells growth and metastasis: implication of Wnt/catenin beta and MEK/ ERK signaling pathways
(Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 15, 2024 Category: Cancer & Oncology Authors: Ruitao Zhang, Huirong Shi, Fang Ren, Wei Feng, Yuan Cao, Gailing Li, Zheying Liu, Pengcheng Ji and Minghui Zhang Tags: Retraction Note Source Type: research

IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis
Nasopharyngeal carcinoma (NPC) poses a significant health burden in specific regions of Asia, and some of NPC patients have bone metastases at the time of initial diagnosis. Bone metastasis can cause pathologi... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 12, 2024 Category: Cancer & Oncology Authors: Kaifan Yang, Yanjun Hu, Yuanyuan Feng, Kaiqun Li, Ziyan Zhu, Shuyi Liu, Yanling Lin and Bin Yu Tags: Research Source Type: research

From glioma gloom to immune bloom: unveiling novel immunotherapeutic paradigms-a review
In tumor therapeutics, the transition from conventional cytotoxic drugs to targeted molecular therapies, such as those targeting receptor tyrosine kinases, has been pivotal. Despite this progress, the clinical... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 12, 2024 Category: Cancer & Oncology Authors: Moksada Regmi, Yingjie Wang, Weihai Liu, Yuwei Dai, Shikun Liu, Ke Ma, Guozhong Lin, Jun Yang, Hongyi Liu, Jian Wu and Chenlong Yang Tags: Review Source Type: research

RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling
Metastasis is one of the leading cause contributes to treatment failure and poor prognosis of hepatocellular carcinoma (HCC) patients. The underlying mechanism of HCC metastasis remains to be determined. Altho... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 8, 2024 Category: Cancer & Oncology Authors: Yu-Jiao Zhou, Min-Li Yang, Xin He, Hui-Ying Gu, Ji-Hua Ren, Sheng-Tao Cheng, Zhou Fu, Zhen-Zhen Zhang and Juan Chen Tags: Research Source Type: research

The epigenetic downregulation of LncGHRLOS mediated by RNA m6A methylase ZCCHC4 promotes colorectal cancer tumorigenesis
m6A modification is currently recognized as a major driver of RNA function that maintains cancer cell homeostasis. Long non-coding (Lnc) RNAs control cell proliferation and play an important role in the occurr... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 7, 2024 Category: Cancer & Oncology Authors: Ke Chen, Jingcheng Zhang, Lei Meng, Lingshang Kong, Ming Lu, Zhengguang Wang and Wenbin Wang Tags: Research Source Type: research

Galectin-3 and cancer immunotherapy: a glycobiological rationale to overcome tumor immune escape
Immunotherapy with checkpoint inhibitors (ICIs) has radically changed the landscape of therapeutic opportunities in oncology, but much still needs to be understood from a mechanistic point of view. There is sp... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 6, 2024 Category: Cancer & Oncology Authors: Giorgia Scafetta, Calogero D ’Alessandria and Armando Bartolazzi Tags: Commentary Source Type: research

PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer
This study aimed to study the role of PARD3 in hepatic tumorigenesis. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 6, 2024 Category: Cancer & Oncology Authors: Junyu Wu, Hor-Yue Tan, Yau-Tuen Chan, Yuanjun Lu, Zixin Feng, Hongchao Yuan, Cheng Zhang, Yibin Feng and Ning Wang Tags: Research Source Type: research

Inhibition of choline metabolism in an angioimmunoblastic T-cell lymphoma preclinical model reveals a new metabolic vulnerability as possible target for treatment
Angioimmunoblastic T-cell lymphoma (AITL) is a malignancy with very poor survival outcome, in urgent need of more specific therapeutic strategies. The drivers of malignancy in this disease are CD4+ follicular hel... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 6, 2024 Category: Cancer & Oncology Authors: Adrien Krug, Marie Tosolini, Blandine Madji Hounoum, Jean-Jacques Fourni é, Roger Geiger, Matteo Pecoraro, Patrick Emond, Philippe Gaulard, François Lemonnier, Jean-Ehrland Ricci and Els Verhoeyen Tags: Research Source Type: research

Correction: c-Myc-activated long non-coding RNA LINC01050 promotes gastric cancer growth and metastasis by sponging miR-7161-3p to regulate SPZ1 expression
(Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 5, 2024 Category: Cancer & Oncology Authors: Ziwei Ji, Tianbin Tang, Mengxia Chen, Buyuan Dong, Wenjing Sun, Nan Wu, Hao Chen, Qian Feng, Xingyi Yang, Rong Jin and Lei Jiang Tags: Correction Source Type: research

Correction: RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding
(Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 2, 2024 Category: Cancer & Oncology Authors: Ying Lin, Yun Wu, Qiangzu Zhang, Xunwei Tu, Sufang Chen, Junfan Pan, Nengluan Xu, Ming Lin, Peiwei She, Gang Niu, Yusheng Chen and Hongru Li Tags: Correction Source Type: research

T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution
Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune cells can impair this response and help tumor immune escape. Th... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 2, 2024 Category: Cancer & Oncology Authors: Wenhui Yang, Shimao Liu, Mengyun Mao, Yandong Gong, Xiaohui Li, Tianyu Lei, Chao Liu, Shikai Wu and Qinyong Hu Tags: Review Source Type: research

TRIM25 promotes glioblastoma cell growth and invasion via regulation of the PRMT1/c-MYC pathway by targeting the splicing factor NONO
Ubiquitination plays an important role in proliferating and invasive characteristic of glioblastoma (GBM), similar to many other cancers. Tripartite motif 25 (TRIM25) is a member of the TRIM family of proteins... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 2, 2024 Category: Cancer & Oncology Authors: Yike Chen, Xiaohui Xu, Kaikai Ding, Tianchi Tang, Feng Cai, Haocheng Zhang, Zihang Chen, Yangjian Qi, Zaixiang Fu, Ganggui Zhu, Zhangqi Dou, Jinfang Xu, Gao Chen, Qun Wu, Jianxiong Ji and Jianmin Zhang Tags: Research Source Type: research

Lactylation stabilizes DCBLD1 activating the pentose phosphate pathway to promote cervical cancer progression
Discoidin, CUB, and LCCL domain-containing type I (DCBLD1) is identified as an oncogene involved in multiple regulation of tumor progression, but specific mechanisms remain unclear in cervical cancer. Lactate-... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 31, 2024 Category: Cancer & Oncology Authors: Qingfei Meng, Huihui Sun, Yanghe Zhang, Xiangzhe Yang, Shiming Hao, Bin Liu, Honglan Zhou, Zhi-Xiang Xu and Yishu Wang Tags: Research Source Type: research

FBW7/GSK3 β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer
The development of radioresistance seriously hinders the efficacy of radiotherapy in lung cancer. However, the underlying mechanisms by which radioresistance occurs are still incompletely understood. The N6-Methy... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 29, 2024 Category: Cancer & Oncology Authors: Zhiyuan Zhou, Bin Zhang, Yue Deng, Suke Deng, Jie Li, Wenwen Wei, Yijun Wang, Jiacheng Wang, Zishan Feng, Mengjie Che, Xiao Yang, Jingshu Meng, Yan Li, Yan Hu, Yajie Sun, Lu Wen & hellip; Tags: Research Source Type: research

EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL
Hepatocellular Carcinoma (HCC) is a matter of great global public health importance; however, its current therapeutic effectiveness is deemed inadequate, and the range of therapeutic targets is limited. The ai... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 29, 2024 Category: Cancer & Oncology Authors: Mingang Pan, Muyu Luo, Lele Liu, Yunmeng Chen, Ziyi Cheng, Kai Wang, Luyi Huang, Ni Tang, Jianguo Qiu, Ailong Huang and Jie Xia Tags: Research Source Type: research