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Correction: circPVT1 regulates medullary thyroid cancer growth and metastasis by targeting miR-455-5p to activate CXCL12/CXCR4 signaling
(Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 14, 2023 Category: Cancer & Oncology Authors: Xun Zheng, Shu Rui, Xiao-Fei Wang, Xiu-He Zou, Yan-Ping Gong and Zhi-Hui Li Tags: Correction Source Type: research

Differential immunomodulatory effects of epirubicin/cyclophosphamide and docetaxel in breast cancer patients
Epirubicin/cyclophosphamide (EC) and docetaxel (D) are commonly used in a sequential regimen in the neoadjuvant treatment of early, high-risk or locally advanced breast cancer (BC). Novel approaches to increas... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 14, 2023 Category: Cancer & Oncology Authors: Kerstin Wimmer, Monika Sachet, Cristiano Ramos, Sophie Frantal, Hanna Birnleitner, Christine Brostjan, Ruth Exner, Martin Filipits, Zsuzsanna Bago-Horvath, Margaretha Rudas, Rupert Bartsch, Michael Gnant, Christian F. Singer, Marija Balic, Daniel Egle, Ru Tags: Research Source Type: research

MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density
Inherited defects in the base-excision repair gene MBD4 predispose individuals to adenomatous polyposis and colorectal cancer, which is characterized by an accumulation of C  > T transitions resulting from spon... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 14, 2023 Category: Cancer & Oncology Authors: Christophe Papin, Abdulkhaleg Ibrahim, Jamal S. M. Sabir, St éphanie Le Gras, Isabelle Stoll, Raed S. Albiheyri, Ali T. Zari, Ahmed Bahieldin, Alfonso Bellacosa, Christian Bronner and Ali Hamiche Tags: Research Source Type: research

Anti-tumor activity of all-trans retinoic acid in gastric-cancer: gene-networks and molecular mechanisms
Gastric-cancer is a heterogeneous type of neoplastic disease and it lacks appropriate therapeutic options. There is an urgent need for the development of innovative pharmacological strategies, particularly in ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 11, 2023 Category: Cancer & Oncology Authors: Luca Guarrera, Mami Kurosaki, Silvio-Ken Garattini, Maurizio Gianni ’, Gianpiero Fasola, Luca Rossit, Michele Prisciandaro, Maria Di Bartolomeo, Marco Bolis, Paola Rizzo, Claudia Nastasi, Marika Foglia, Adriana Zanetti, Gabriela Paroni, Mineko Terao and Tags: Research Source Type: research

Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer
Long noncoding RNAs (lncRNAs) have been reported to play vital roles in the development and progression of cancer. However, their biological significance and functional mechanisms in non-small cell lung cancer... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 10, 2023 Category: Cancer & Oncology Authors: Li Zhang, Jingtian Liang, Hao Qin, Yin Lv, Xiucheng Liu, Zhuoqun Li, Zhixiang Chao, Caili Jia, Xichun Qin and Hao Zhang Tags: Research Source Type: research

Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer
The Hippo pathway is crucial in organ size control and tumorigenesis. Dysregulation of the Hippo/YAP axis is commonly observed in gastric cancer, while effective therapeutic targets for the Hippo/YAP axis are ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 10, 2023 Category: Cancer & Oncology Authors: Tianshi Wang, Dehai Wang, Yanan Sun, Ting Zhuang, Xin Li, Huijie Yang, Yifeng Zang, Ziping Liu, Penghe Yang, Chenmiao Zhang, Jiayao Cui, Mingxi Fu, Shuqing Zhang, Peng Su, Zhongbo Li, Jian Zhu & hellip; Tags: Research Source Type: research

PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway
Ovarian cancer is commonly associated with a poor prognosis due to metastasis and chemoresistance. PINK1 (PTEN-induced kinase 1) is a serine/threonine kinase that plays a crucial part in regulating various physio... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 9, 2023 Category: Cancer & Oncology Authors: Fang Zheng, Jiamin Zhong, Kelie Chen, Yu Shi, Fang Wang, Shengchao Wang, Song Tang, Xiaoyu Yuan, Zhangjin Shen, Sangsang Tang, Dajing Xia, Yihua Wu and Weiguo Lu Tags: Research Source Type: research

MYL9 expressed in cancer-associated fibroblasts regulate the immune microenvironment of colorectal cancer and promotes tumor progression in an autocrine manner
The tumor microenvironment (TME) is an important factor that regulates the progression of colorectal cancer (CRC). Cancer-associated fibroblasts (CAFs) are the main mesenchymal cells in the TME and play a vita... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 6, 2023 Category: Cancer & Oncology Authors: Shenghe Deng, Denglong Cheng, Jun Wang, Junnan Gu, Yifan Xue, Zhenxing Jiang, Le Qin, Fuwei Mao, Yinghao Cao and Kailin Cai Tags: Research Source Type: research

Suppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR
Triple-negative breast cancer (TNBC) is characterized by aggressive growth and a high propensity for recurrence and metastasis. Simultaneous overexpression of c-MET and EGFR in TNBC is associated with worse cl... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 4, 2023 Category: Cancer & Oncology Authors: Seongjae Kim, Jung Min Park, Soeun Park, Eunsun Jung, Dongmi Ko, Minsu Park, Juyeon Seo, Kee Dal Nam, Yong Koo Kang, Kyoungmin Lee, Lee Farrand, Yoon-Jae Kim, Ji Young Kim and Jae Hong Seo Tags: Research Source Type: research

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood, whose prognosis is still poor especially for metastatic, high-grade, and relapsed RMS. New treatments are urgently needed, especially... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 4, 2023 Category: Cancer & Oncology Authors: Andrea Timpanaro, Caroline Piccand, Dzhangar Dzhumashev, Stenija Anton-Joseph, Andrea Robbi, Janine Moser, Jochen R össler and Michele Bernasconi Tags: Research Source Type: research

Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity
Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of amino acid metabolic strateg... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 3, 2023 Category: Cancer & Oncology Authors: Yue Zheng, Yiran Yao, Tongxin Ge, Shengfang Ge, Renbing Jia, Xin Song and Ai Zhuang Tags: Review Source Type: research

Tumor-associated macrophage-derived exosomes LINC01592 induce the immune escape of esophageal cancer by decreasing MHC-I surface expression
TAMs (tumor-associated macrophages) infiltration promotes the progression of esophageal cancer (EC). However, the underlying mechanisms remain unclear. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 2, 2023 Category: Cancer & Oncology Authors: Xinwei Qiao, Zaixing Cheng, Kaming Xue, Cui Xiong, Zhikun Zheng, Xin Jin and Jinsong Li Tags: Research Source Type: research

FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression
Invasion and metastasis are the main causes of unfavourable prognosis in patients diagnosed with bladder cancer. The efficacy of immunotherapy in bladder cancer remains suboptimal due to the presence of an imm... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 2, 2023 Category: Cancer & Oncology Authors: Wei-Min Hu, Ming Li, Jin-Zhuo Ning, Yu-Qi Tang, Tian-Bao Song, Lin-Zhi Li, Fan Zou, Fan Cheng and Wei-Min Yu Tags: Research Source Type: research

Circulating small extracellular vesicle-derived splicing factor 3b subunit 4 as a non-invasive diagnostic biomarker of early hepatocellular carcinoma
Hepatocellular carcinoma (HCC) accounts for a majority of primary liver cancer cases and related deaths. The purpose of this study was to assess the diagnostic value of splicing factor 3b subunit 4 (SF3B4) as ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - October 30, 2023 Category: Cancer & Oncology Authors: Ju A Son, Ji Hyang Weon, Geum Ok Baek, Hye Ri Ahn, Ji Yi Choi, Moon Gyeong Yoon, Hyo Jung Cho, Jae Youn Cheong, Jung Woo Eun and Soon Sun Kim Tags: Research Source Type: research

Albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis
Temozolomide (TMZ) treatment efficacy in glioblastoma (GBM) patients has been limited by resistance in the clinic. Currently, there are no clinically proven therapeutic options available to restore TMZ treatme... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - October 28, 2023 Category: Cancer & Oncology Authors: Shanqiang Qu, Songtao Qi, Huayang Zhang, Zhiyong Li, Kaicheng Wang, Taichen Zhu, Rongxu Ye, Wanghao Zhang, Guanglong Huang and Guo-zhong Yi Tags: Research Source Type: research