Journal of Experimental and Clinical Cancer Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The dopamine receptor D1 inhibitor, SKF83566, suppresses GBM stemness and invasion through the DRD1-c-Myc-UHRF1 interactions
Extensive local invasion of glioblastoma (GBM) cells within the central nervous system (CNS) is one factor that severely limits current treatments. The aim of this study was to uncover genes involved in the in... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 22, 2024 Category: Cancer & Oncology Authors: Zhiyi Xue, Yan Zhang, Ruiqi Zhao, Xiaofei Liu, Konrad Gr ützmann, Barbara Klink, Xun Zhang, Shuai Wang, Wenbo Zhao, Yanfei Sun, Mingzhi Han, Xu Wang, Yaotian Hu, Xuemeng Liu, Ning Yang, Chen Qiu & hellip; Tags: Research Source Type: research

Correction: METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression
(Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 22, 2024 Category: Cancer & Oncology Authors: Wei Wei, Zhong-Yuan Zhang, Bin Shi, Yike Cai, Hou-Shun Zhang, Chun-Lei Sun, Yun-Fei Fei, Wen Zhong, Shuang Zhang, Chen Wang, Bing He, Guan-Min Jiang and Hao Wang Tags: Correction Source Type: research

Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery
Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved in almost all cancer hallmark features including tumor proliferation, metastasis, angiogenesis, immunosuppression... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 20, 2024 Category: Cancer & Oncology Authors: Yamei Hu, Zigang Dong and Kangdong Liu Tags: Review Source Type: research

High and selective cytotoxicity of ex vivo expanded allogeneic human natural killer cells from peripheral blood against bladder cancer: implications for natural killer cell instillation after transurethral resection of bladder tumor
Non-muscle-invasive bladder cancer (NMIBC) is treated with transurethral resection of bladder tumor (TURBT) followed by intravesical instillation of chemotherapy or Bacillus Calmette –Guérin therapy. However, t... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 20, 2024 Category: Cancer & Oncology Authors: Fangming Wang, Gang Zhang, Tianli Xu, Jianlin Ma, Jing Wang, Shuai Liu, Yuzhe Tang, Song Jin, Jianxing Li and Nianzeng Xing Tags: Research Source Type: research

Correction: Tumor immune microenvironment-based therapies in pancreatic ductal adenocarcinoma: time to update the concept
(Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 18, 2024 Category: Cancer & Oncology Authors: Wenyu Luo, Ti Wen and Xiujuan Qu Tags: Correction Source Type: research

LINC00571 drives tricarboxylic acid cycle metabolism in triple-negative breast cancer through HNRNPK/ILF2/IDH2 axis
Triple-negative breast cancer is a complex breast malignancy subtype characterized by poor prognosis. The pursuit of effective therapeutic approaches for this subtype is considerably challenging. Notably, rece... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 18, 2024 Category: Cancer & Oncology Authors: Zihan Xi, Haohao Huang, Jin Hu, Yuanhang Yu, Xianxiong Ma, Ming Xu, Jie Ming, Lei Li, Hui Zhang, Hengyu Chen and Tao Huang Tags: Research Source Type: research

LncRNA AL139294.1 can be transported by extracellular vesicles to promote the oncogenic behaviour of recipient cells through activation of the Wnt and NF- κB2 pathways in non-small-cell lung cancer
Extracellular vesicles (EVs) participate in cancer development via cell-to-cell communication. Long non-coding RNAs (lncRNAs), one component of EVs, can play an essential role in non-small-cell lung cancer (NS... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 16, 2024 Category: Cancer & Oncology Authors: Xinyi Ma, Zhenhua Chen, Wei Chen, Ziyuan Chen, Yue Shang, Yikai Zhao, Leyi Li, Chengwei Zhou, Jinxian He and Xiaodan Meng Tags: Research Source Type: research

Modulating ferroptosis sensitivity: environmental and cellular targets within the tumor microenvironment
Ferroptosis, a novel form of cell death triggered by iron-dependent phospholipid peroxidation, presents significant therapeutic potential across diverse cancer types. Central to cellular metabolism, the metabo... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 13, 2024 Category: Cancer & Oncology Authors: Yuze Hua, Sen Yang, Yalu Zhang, Jiayi Li, Mengyi Wang, Palashate Yeerkenbieke, Quan Liao and Qiaofei Liu Tags: Review Source Type: research

TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression
As a novel necrosis manner, ferroptosis has been increasingly reported to play a role in tumor progression and treatment, however, the specific mechanisms underlying its development in prostate cancer remain u... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 11, 2024 Category: Cancer & Oncology Authors: Yu Zhang, Zhenlin Huang, Keqiang Li, Guoqing Xie, Yuankang Feng, Zihao Wang, Ningyang Li, Ruoyang Liu, Yinghui Ding, Jun Wang, Jinjian Yang and Zhankui Jia Tags: Research Source Type: research

PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer
In this study, we aim to investigate its functions and underlying mechanisms in the context of gas... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 11, 2024 Category: Cancer & Oncology Authors: Liang Xu, Wanying Xiang, Jiezhen Yang, Jing Gao, Xinyue Wang, Li Meng, Kaihong Ye, Xiao Hong Zhao, Xu Dong Zhang, Lei Jin and Yan Ye Tags: Research Source Type: research

Marinopyrrole derivative MP1 as a novel anti-cancer agent in group 3 MYC-amplified Medulloblastoma
Medulloblastoma (MB) patients with MYC oncogene amplification or overexpression exhibit extremely poor prognoses and therapy resistance. However, MYC itself has been one of the most challenging targets for can... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 11, 2024 Category: Cancer & Oncology Authors: Don W. Coulter, Yashpal S. Chhonker, Devendra Kumar, Varun Kesherwani, Wafaa N. Aldhafiri, Erin M. McIntyre, Gracey Alexander, Sutapa Ray, Shantaram S. Joshi, Rongshi Li, Daryl J. Murry and Nagendra K. Chaturvedi Tags: Research Source Type: research

EMID2 is a novel biotherapeutic for aggressive cancers identified by in vivo screening
New drugs to tackle the next pathway or mutation fueling cancer are constantly proposed, but 97% of them are doomed to fail in clinical trials, largely because they are identified by cellular or in silico scre... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 10, 2024 Category: Cancer & Oncology Authors: Ambra Cappelletto, Edoardo Alf ì, Nina Volf, Thi Van Anh Vu, Francesca Bortolotti, Giulio Ciucci, Simone Vodret, Marco Fantuz, Martina Perin, Andrea Colliva, Giacomo Rozzi, Matilde Rossi, Giulia Ruozi, Lorena Zentilin, Roman Vuerich, Daniele Borin & hell Tags: Research Source Type: research

Natural killer cells drive 4-1BBL positive uveal melanoma towards EMT and metastatic disease
Inflammation in the eye is often associated with aggravated ocular diseases such as uveal melanoma (UM). Poor prognosis of UM is generally associated with high potential of metastatic liver dissemination. A st... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 9, 2024 Category: Cancer & Oncology Authors: Shi Yong Neo, Mariana M. S. Oliveira, Le Tong, Yi Chen, Ziqing Chen, Sonia Cismas, Nutsa Burduli, Anna Malmerfelt, Joey Kay Hui Teo, Kong-Peng Lam, Evren Alici, Leonard Girnita, Arnika K. Wagner, Lisa S. Westerberg and Andreas Lundqvist Tags: Research Source Type: research

The E3 ligase NEURL3 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma by promoting vimentin degradation
Metastasis has emerged as the major reason of treatment failure and mortality in patients with nasopharyngeal carcinoma (NPC). Growing evidence links abnormal DNA methylation to the initiation and progression ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 9, 2024 Category: Cancer & Oncology Authors: Shi-Qing Zhou, Ping Feng, Ming-Liang Ye, Sheng-Yan Huang, Shi-Wei He, Xun-Hua Zhu, Jun Chen, Qun Zhang and Ying-Qing Li Tags: Research Source Type: research

Current and future therapeutic strategies for high-grade gliomas leveraging the interplay between epigenetic regulators and kinase signaling networks
Targeted therapies, including small molecule inhibitors directed against aberrant kinase signaling and chromatin regulators, are emerging treatment options for high-grade gliomas (HGG). However, when translati... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 5, 2024 Category: Cancer & Oncology Authors: Lea M. Stitzlein, Jack T. Adams, Erin N. Stitzlein, Richard W. Dudley and Joya Chandra Tags: Review Source Type: research