Journal of Cardiothoracic and Vascular Anesthesia This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Aviptadil as a promising intervention: a case study for TRALI treatment in a cardiac patient
Aviptadil is a synthetic Vasoactive Intestinal Polypeptide (VIP) discovered in 1970 by Said and Mutt(1). VIP binds to the VPAC1 receptor of the Alveolar Type (AT) II cell and has been shown to block replication of the Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) resulting in clinical and radiographic improvement. Sars-COV2 virus binds to the AT II cells via the Angiotensin-converting enzymes (ACE) 2 receptor. Unlike other anti-cytokine drugs, Aviptadil has a specific role in preserving lung surfactant production and protecting AT II cells. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 21, 2024 Category: Anesthesiology Authors: Chinmaya Nanda, Chitra Mehta, Yatin Mehta, Swati Joshi, Anmol Bhan, Anil Bhan Tags: Letter to Editor Source Type: research

Methadone should not be used in cardiac surgery as part of Enhanced Recovery after Cardiac Surgery (ERACS) protocol
Methadone, originally synthesized during World War II as an analgesic substitute for morphine, is well known to the world of addiction medicine.1 Methadone's mechanism of action is multi-faceted – acting as a primary mu-receptor agonist with some kappa- and delta-receptor activity, pre-synaptic N-methyl-D-aspartate (NMDA) receptor antagonist, and inhibitor of norepinephrine and serotonin reuptake in the brain.2,3 With the introduction of Gourlay et al.’s4,5 investigations in the 1980s, integration of intravenous methadone into perioperative management has shown promise but strong clinical research remains lacking, part...
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 21, 2024 Category: Anesthesiology Authors: Stephanie O. Ibekwe, Lauren Everett, Samhati Mondal Tags: Pro and Con Source Type: research

Sex Based Differences in Opioid Administration: A Puzzle Yet to be Solved.
To the Editor: (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 21, 2024 Category: Anesthesiology Authors: Aimee Pak, Hannah Smith, Hisako Okada, Amir L. Butt Tags: Letter to the Editor Source Type: research

Carbon footprint of total intravenous and inhalational anesthesia in the transcatheter aortic valve replacement procedure
We aimed to quantify and compare the emissions for deep sedation with TIVA and general anesthesia with inhaled agents during the transcatheter aortic valve replacement procedure. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 21, 2024 Category: Anesthesiology Authors: Lei Yang, Joshua Hubert, Samwel Gitundu, Ethan Brovman, Frederick Cobey Tags: Original Article Source Type: research

Commentary On An Intracardiac Shunt in a Patient Undergoing Left Ventricular Assist Device Implantation
In this issue of the Journal of Cardiothoracic and Vascular Anesthesia, Scheiber et al describe the nuances of decision-making when deciding whether or not to pursue closure of a patient foramen ovale at the time of left ventricular assist device implantation [1]. This is a situation very frequently seen by cardiac surgeons and cardiothoracic anesthesiologists, who attempt to make the best decision for each patient, without guidance from a field of evidence or our academic societies on the best course of action. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 21, 2024 Category: Anesthesiology Authors: Amrita Sukhavasi, Aurelie Merlo Tags: Invited Commentary Source Type: research

Pro: Methadone should be used as a part of Enhanced Recovery after Cardiac Surgery (ERACS) protocol
Methadone is a highly effective synthetic opioid (FDA approved in 1947) used primarily in opioid use disorder treatment but has been studied and used for acute perioperative pain treatment. Its duration of action is highly dependent on dose and frequency. Methadone has a short speed of onset of 6-8 minutes and redistribution half-life of approximately 6 minutes but with increasing dosage (>= 20 mg) its elimination half-life is extended to approximately 30 hours (range 8 ≥ 59 hours).1,2 Methadone's mechanism of action involves effects at several sites central in nociception including mu-opioid receptor, N-methyl-D-Asparta...
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 21, 2024 Category: Anesthesiology Authors: Shelby Garcia, Mitali Mali, Ashanpreet Grewal Tags: Pro and Con Source Type: research

Should Patients Taking Sodium-Glucose Co-Transporter 2 Inhibitors Be Dropped From the Elective Surgical Program?
SODIUM-GLUCOSE cotransporter 2 inhibitors (SGLT2i) have proven to play a key role as pleiotropic drugs beyond the treatment of type 2 diabetes mellitus, promoting cardiovascular and renal-protective benefits even in nondiabetic patients. Moreover, SGLT2i have stepped into the spotlight in the management of patients with heart failure with a preserved ejection fraction and chronic kidney diseases. Empagliflozin reduced event rates of myocardial infarction, cardiovascular death, and strokes in type 2 diabetes mellitus patients compared with placebo, also decreasing hospitalization for cardiac failure. (Source: Journal of Car...
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 19, 2024 Category: Anesthesiology Authors: Sylvia Ryz, Clara Castellucci Tags: Pro and Con Source Type: research

Should Patients Taking Sodium-Glucose Cotransporter 2 Inhibitors Be Dropped From the Elective Surgical Program?
SODIUM-GLUCOSE cotransporter 2 inhibitors (SGLT2i) are a new and potent drug class for the treatment of type 2 diabetes mellitus. Inhibition of the SGLT2 protein in the proximal tubule of the kidney leads to increased excretion of glucose and sodium, resulting in weight-loss reduction in blood pressure and hemoglobin A1c levels. Extensive clinical trials have demonstrated effective cardiovascular and kidney-protective effects, even in patients without diabetes. The US Food and Drug Administration approved SGLT2i for treating heart failure and chronic kidney disease for patients without diabetes, leading to an increased pre...
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 19, 2024 Category: Anesthesiology Authors: Peter Wohlrab, Martin H. Bernardi Tags: Pro and Con Source Type: research

Setting positive end-expiratory pressure in primary lung graft dysfunction: a prospective physiologic study.
Although setting positive end-expiratory pressure (PEEP) to minimize alveolar collapse and overdistension is crucial for lung protective ventilation [1], the best strategy in patients suffering from primary graft dysfunction (PGD) after bilateral lung transplant (BLT) remains indeterminate [2,3]. This physiologic prospective study aims to assess and compare optimal PEEP levels, estimated with different methods, in this patient population. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 19, 2024 Category: Anesthesiology Authors: Francesco Zarantonello, Tommaso Pettenuzzo, Chiara Pretto, Annalisa Boscolo, Nicol ò Sella, Paolo Navalesi Tags: Letter to the Editor Source Type: research

Pro/Con: Should patients taking SGLT2 inhibitors be dropped from the elective surgical program?
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have proven to play a key role as pleiotropic drugs beyond treatment of type 2 diabetes mellitus, promoting cardiovascular and renal-protective benefits even in non-diabetic patients. Moreover, SGLT2i have stepped into the spotlight in management of patients with heart failure with a preserved ejection fraction and chronic kidney diseases. Empagliflozin reduced event rates of myocardial infarction, cardiovascular death and strokes in type 2 diabetes mellitus patients compared to placebo, also decreasing hospitalization for cardiac failure [1]. (Source: Journal of Cardiotho...
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 19, 2024 Category: Anesthesiology Authors: Sylvia Ryz, Clara Castellucci Tags: Pro and Con Source Type: research

Pro/Con: Should patients taking SGLT2 inhibitors be dropped from the elective surgical program?
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new and potent drug class for the treatment of type 2 diabetes mellitus. Inhibition of the SGLT2 protein in the proximal tubule of the kidney leads to increased excretion of glucose and sodium, resulting in weight loss reduction in blood pressure and hemoglobin A1c levels. Extensive clinical trials have demonstrated impactful cardiovascular and kidney-protective effects, even in patients without diabetes. The US Food and Drug Administration (FDA) approved SGLT2i for treating heart failure and chronic kidney disease for patients without diabetes, leading to an increas...
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 19, 2024 Category: Anesthesiology Authors: Peter Wohlrab, Martin H. Bernardi Tags: Pro and Con Source Type: research

Can Lightning Strike Twice? Double Sequential External Defibrillation, Extracorporeal Cardiopulmonary Resuscitation, and the International Liaison Committee on Resuscitation Guidelines
“Practice guidelines are systematically developed statements to assist practitioner and patient decisions about appropriate healthcare for specific clinical circumstances.”1 This is the definition of a guideline published by the National Academy of Medicine (formally the Institute of Medicine). This is important to keep in mind when assessing guidelines, and the latest annual raft of recommendations from the International Liaison Committee on Resuscitation (ILCOR) is no exception. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 16, 2024 Category: Anesthesiology Authors: Kelly Byrne, Mikaela Garland, Elizabeth Turner Tags: Editorial Source Type: research

Relationship Between Computed Tomography –Derived Left Bronchial Diameter and Double- Lumen Endotracheal Tube Size Selection
Many anesthesiologists use patient sex and height to determine double-lumen tube (DLT) size, but there are no formal guidelines.1 Preoperative computed tomography may serve as a guide to determine DLT size, but studies examining this have had important limitations.2-5 Instead of theoretical size ranges, we performed a pilot study to identify which patients have had a properly sized DLT placed, and reported the observed left bronchial diameters. To assess the reproducibility of this technique, 4 investigators repeated measurements to assess interobserver variability. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 16, 2024 Category: Anesthesiology Authors: Alan M. Smeltz, Ashley B. Wicker, Dustin J. Belliston-Fowkes, Linh N. Tran, Emmaline J. Smith, Xinming An, Bridget I. Lin, Emily G. Teeter Tags: Letter to the Editor Source Type: research

Can lightning strike twice? DSED, ECPR and the ILCOR guidelines.
“Practice guidelines are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances.”1 This is the definition of a guideline published by the National Academy of Medicine (formally the Institute of Medicine). This is important to keep in mind when assessing guidelines and the latest annual raft of recommendations from the International Liaison Committee on Resuscitation(ILCOR) is no exception to this. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 16, 2024 Category: Anesthesiology Authors: Kelly Byrne, Mikaela Garland, Elizabeth Turner Tags: Editorial Source Type: research

The relationship between computed tomography-derived left bronchial diameter and double lumen endotracheal tube size selection
To the Editor: (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 16, 2024 Category: Anesthesiology Authors: Alan M Smeltz, Ashley B Wicker, Dustin J Belliston-Fowkes, Linh N Tran, Emmaline J Smith, Xinming An, Bridget I Lin, Emily G Teeter Tags: Letter to the Editor Source Type: research