Anti-Xa-guided anticoagulation with unfractionated heparin and thrombosis during ECMO support: A systematic review and meta-analysis
The extracorporeal membrane oxygenation (ECMO) involves complex coagulatory, immunological, and inflammatory processes that may contribute to the development of thromboembolic events, necessitating systemic anticoagulation1-4. However, the use of anticoagulation carries a hazard of severe, life-threatening hemorrhage5-7. Therefore, anticoagulation monitoring is crucial to avoid adverse events3,8-11. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 1, 2024 Category: Anesthesiology Authors: Rajsic Sasa, Breitkopf Robert, Treml Benedikt, Jadzic Dragana, Innerhofer Nicole, Eckhardt Christine, Oberleitner Christoph, Nawabi Fariha, Bukumiric Zoran Tags: Original Article Source Type: research

Risk factors of acute kidney injury in adult patients under veno-arterial extracorporeal membrane oxygenation support
To investigate the incidence and risk factors of acute kidney injury (AKI) stage 3 in adult patients under veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 30, 2024 Category: Anesthesiology Authors: Yuan Teng, Yuan Li, KunYu Li, Qiang Hu, Shujie Yan, Gang Liu, Bingyang Ji, Guodong Gao Tags: Original Article Source Type: research

Is general anesthesia for peripheral vascular surgery correlated with impaired outcome in patients with cardiac comorbidity? A closer look into the nationwide Danish cohort
General anesthesia (GA) may impair outcome after vascular surgery. The use of anticoagulant medication is often used in patients with cardiac comorbidity. Regional anesthesia (RA) requires planning of discontinuation before neuraxial blockade(s) in this subgroup. The aim was to describe the effect of anesthesia choice on outcome after vascular surgery in patients with known cardiac comorbidity. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 29, 2024 Category: Anesthesiology Authors: Luisa K örner, Signe Riddersholm, Christian Torp-Pedersen, Kim Houlind, Jannie Bisgaard Tags: Original Article Source Type: research

Selected 2023 Highlights in Congenital Cardiac Anesthesia
This article reviews the highlights of pertinent literature of interest to the congenital cardiac anesthesiologist published in 2023. Following a search of the United States National Library of Medicine PubMed database, several topics emerged where significant contributions were made in 2023. The authors of this manuscript considered the following topics noteworthy to be included in this review: Advancements in percutaneous mechanical support in children with CHD, children with pulmonary hypertension undergoing surgery for congenital heart disease (CHD), Dexmedetomidine in pediatric cardiac surgery, and recommendations for...
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 28, 2024 Category: Anesthesiology Authors: Ingrid Moreno-Duarte, Rishi Bharat Parikh, Joanna Paquin, Jochen Steppan, James P. Spaeth, Viviane G. Nasr, Alexander J.C. Mittnacht, Emad B. Mossad Tags: Special Article Source Type: research

2024 Guidelines for Performing a Comprehensive Pediatric Transthoracic Echocardiogram: Recommendations From the American Society of Echocardiography
Transthoracic echocardiography (TTE) has become the most utilized imaging modality for diagnosis and management of children and adults with congenital heart disease (CHD). It was not always this way. The history of echocardiography in pediatrics is interesting in that it was only in 1959 that Effert et al. first reported echocardiographic images of congenital heart defects, but the technology at the time could not consistently identify anatomical variations. 1, 2 It was another decade before echocardiography machines improved and normal neonatal and infant echocardiography images were able to be documented and expand the f...
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 28, 2024 Category: Anesthesiology Authors: Nicholas Houska, Megan Albertz, Benjamin Frank, Richard J. Ing Tags: Editorial Source Type: research

A Rare Right-To-Left Shunt In A Child Following Fontan Completion Contributing to Cyanosis
An 8-year-old boy [weight:17kg; height; 102cm] with complex congenital heart disease presented to our institution for evaluation of cyanosis [arterial oxygen saturation measuring 85-90%] with minimal exertion after Fontan completion. During infancy, the boy was diagnosed with transposition of the great arteries, tricuspid atresia, hypoplastic right ventricle, and a large ventricular septal defect. The child underwent pulmonary artery banding at the age of 1 year, a Damus Kaye Stansel procedure [the main pulmonary artery was connected to the aorta to bypass a subaortic obstruction] along with a modified right Blalock-Taussi...
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 27, 2024 Category: Anesthesiology Authors: Dr. Madan Mohan Maddali, Dr. Khalid Al Alawi, Dr. Salim Nasser Al Maskari, Dr. Abdullah Mohammed Al Farqani Source Type: research

Mitral Valve Repair on Patients with Chronic Kidney Disease: Long Term Outcomes and Cardiac Remodelling
This study is the first to present long-term outcomes of mortality and morbidity with paired cardiac remodelling data on CKD patients undergoing surgical MVr.Design: A retrospective, observational, comparative study.Setting: Single-center university hospital.Participants: Patients with varying stages of CKD undergoing MVr from 2004-2018.Interventions: Patients were grouped by estimated glomerular filtration (eGFR) rate and followed for a maximum of 15 years. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 27, 2024 Category: Anesthesiology Authors: Jimmy JH. Kang, Sabin J. Bozso, Ryaan EL-Andari, Nicholas M. Fialka, Mortaza F. Hassanabad, Dana Boe, Yongzhe Hong, Michael C. Moon, Darren H. Freed, Jayan Nagendran, Jeevan Nagendran Tags: Original Article Source Type: research

Anesthesia for Combined Heart-Liver Transplantation: a Narrative Review
In 1984, 21 years after the first liver transplantation, Thomas Starzl achieved a milestone by performing the world's first combined heart-liver transplantation. While still uncommon, the practice of combined heart-liver transplants is on the rise globally. In this review, we explore the current literature on this procedure, emphasizing pertinent considerations for anesthesiologists.Over the years, there has been a remarkable increase in the number of combined heart-liver transplantations conducted worldwide. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 27, 2024 Category: Anesthesiology Authors: Kathleen Van Loon, Filip Rega, Jacques Pirenne, Katrijn Jansen, Alexander Van De Bruaene, Geertrui Dewinter, Steffen Rex, Gert-Jan Eerdekens Tags: Review Article Source Type: research

Andexanet Alfa-Induced Heparin Resistance: Sustained Anticoagulant Inefficacy Despite Antithrombin Therapy
Direct-acting oral anticoagulants (DOACs) are widely used as an alternative to warfarin (1). Andexanet alfa was specifically developed to reverse the effects of direct-acting factor Xa inhibitors. It acts as a decoy for factor Xa and binds to direct-acting factor Xa inhibitors, preventing them from binding to endogenous factor Xa (2). The risk of bleeding increases during emergency surgeries in patients on DOACs, necessitating the use of a neutralizing agent (3). However, Andexanet alfa also binds to unfractionated heparin (UFH)-antithrombin complexes, leading to instances of heparin resistance (4). (Source: Journal of Car...
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 27, 2024 Category: Anesthesiology Authors: Kohei Nagashima, Chikara Ueki, Junpei Numari, Naoto Yamaki, Toshikuni Yamamoto, Shigefumi Matsuyama Tags: Case Report Source Type: research

Pro: Normothermic Regional Perfusion Should Be Utilized In Orthotopic Heart Transplantation.
The prevalence of heart failure has increased in the last few decades with an estimate of over 8 million American to have heart failure by 2030.1 At the same time, the number of Donation after Brain Death (DBD) heart donors has remained overall unchanged for over a decade.2 This imbalance led to a surge in the demand for heart transplants. This rising need has propelled the transplant communities to explore new avenues to expand the donor pool like the inclusion of public health services high-risk donors, such as hepatitis C or COVID positive donors, xenografts, and more recently, Donation after Circulatory Death (DCD). (S...
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 27, 2024 Category: Anesthesiology Authors: Mohammad Alarfaj, Zubair Shah Tags: Pro and Con Source Type: research

Neutrophil-to-lymphocyte ratio: A promising predictor of mortality in patients with acute respiratory distress syndrome – a retrospective analysis of a single hospital centre
To examine how the neutrophil-to-lymphocyte ratio (NLR) affects both short-term and long-term mortality in individuals with acute respiratory distress syndrome (ARDS). (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 26, 2024 Category: Anesthesiology Authors: Qiyan Lou Tags: Original Article Source Type: research

Does Platelet Transfusion Increase the Risk for Healthcare Associated Infection in Cardiac Surgical Patients?
Although platelets are commonly transfused in cardiac surgery for thrombocytopenia and to treat post cardiopulmonary bypass (CPB) coagulopathy, platelet transfusion is also plagued by significant challenges including frequent product shortages, inventory management problems, and the potential for bacterial contamination, which can cause sepsis. Transfusion-related bacterial infection occurs most commonly with platelet transfusion because platelets are typically stored at room temperature, which facilitates bacterial growth. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 25, 2024 Category: Anesthesiology Authors: Brian Cho, Nadia B. Hensley, Michael Mazzeffi Tags: Editorial Source Type: research

Optimizing Hemodynamic Management in the Neonatal Intensive Care Unit: Leveraging Neonatal Echocardiography
Intensive care of the neonate involves a delicate balance of monitoring, intervention, and adaptation, particularly in the face of hemodynamic instability. Neonatal hemodynamic management has become increasingly sophisticated and comprehensive in recent years, driven by a deeper understanding of cardiovascular physiology and the development of innovative diagnostic and therapeutic modalities. Traditionally, hemodynamic status and end-organ perfusion are assessed utilizing measurements of heart rate, blood pressure, serum lactate, capillary refill time, and urine output. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 25, 2024 Category: Anesthesiology Authors: Kan Zhang, Anna M. Ray, James A. DiNardo Tags: Invited Commentary Source Type: research

Comparison of the ultrasound-guided supraclavicular and infraclavicular approaches for subclavian vein cannulation in children with congenital heart disease
Central venous catheterization (CVC) is widely used in pediatric critical patients. We thought to compare the success rate and safety of ultrasound-guided subclavian vein cannulation performed via infraclavicular and supraclavicular approaches. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 22, 2024 Category: Anesthesiology Authors: Xiaolei Gong, Nuaini Aikemu, Zhuoming Xu, Limin Zhu Tags: Original Article Source Type: research

Peri-operative risk factors of acute kidney injury after heart transplantation and one-year clinical outcomes: A retrospective cohort study
This study aims to identify perioperative risk factors of acute kidney injury after heart transplantation and to evaluate one-year clinical outcomes. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 21, 2024 Category: Anesthesiology Authors: Geoffroy HARIRI, Paul HENOCQ, Guillaume COUTANCE, Sehmi MANSOURI, Joanna TOHME, J érémie GUILLEMIN, Shaida VARNOUS, Pauline DUREAU, Baptiste DUCEAU, Pascal LEPRINCE, Agnès DECHARTRES, Adrien BOUGLE Tags: Original Article Source Type: research