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The Role of Ubiquitin-Proteasome System in the Pathogenesis of Severe Acute Respiratory Syndrome Coronavirus-2 Disease
Int J Inflam. 2023 Mar 4;2023:6698069. doi: 10.1155/2023/6698069. eCollection 2023.ABSTRACTDifferent protein degradation pathways exist in cells. However, the bulk of cellular proteins are degraded by the ubiquitin-proteasome system (UPS), which is one of these pathways. The upkeep of cellular protein homeostasis is facilitated by the ubiquitin-proteasome system, which has a variety of important functions. With the emergence of eukaryotic organisms, the relationship between ubiquitylation and proteolysis by the proteasome became apparent. Severe acute respiratory syndrome coronavirus-2 (SARS-Coronavirus-2) hijacks the ubiq...
Source: International Journal of Inflammation - March 14, 2023 Category: Allergy & Immunology Authors: Fikadu Seyoum Tola Source Type: research