N-Acetylcysteine Decreases Myocardial Content of Inflammatory Mediators Preventing the Development of Inflammation State and Oxidative Stress in Rats Subjected to a High-Fat Diet
Int J Inflam. 2023 Mar 11;2023:5480199. doi: 10.1155/2023/5480199. eCollection 2023.ABSTRACTArachidonic acid (AA) is a key precursor for proinflammatory and anti-inflammatory derivatives that regulate the inflammatory response. The modulation of AA metabolism is a target for searching a therapeutic agent with potent anti-inflammatory action in cardiovascular disorders. Therefore, our study aims to determine the potential preventive impact of N-acetylcysteine (NAC) supplementation on myocardial inflammation and the occurrence of oxidative stress in obesity induced by high-fat feeding. The experiment was conducted for eight ...
Source: International Journal of Inflammation - March 21, 2023 Category: Allergy & Immunology Authors: Klaudia Sztolsztener Wiktor Bzd ęga Katarzyna Hodun Adrian Chabowski Source Type: research