Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis
Patients with systemic lupus erythematosus (SLE) are highly susceptible to infection and cardiovascular events, suggesting that chronic antigenic stimulation may accelerate premature aging in SLE patients. Pre... (Source: Immunity and Aging)
Source: Immunity and Aging - November 1, 2022 Category: Geriatrics Authors: Ti Zhang, Xin Liu, Yue Zhao, Xiaodong Xu, Yaoyang Liu and Xin Wu Tags: Research Source Type: research
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses
Aging and obesity are high risk factors for several conditions and diseases. They are both associated with systemic inflammation and they are both ameliorated by a healthy life style, suggesting that they may ... (Source: Immunity and Aging)
Source: Immunity and Aging - October 26, 2022 Category: Geriatrics Authors: Daniela Frasca Tags: Comment Source Type: research
Inflammation and cell-to-cell communication, two related aspects in frailty
Frailty is a complex, multi-dimensional age-related syndrome that increases the susceptibility to adverse health outcomes and poor quality of life. A growing consensus supports the contribution of chronic infl... (Source: Immunity and Aging)
Source: Immunity and Aging - October 26, 2022 Category: Geriatrics Authors: Orietta Pansarasa, Maria Chiara Mimmi, Annalisa Davin, Marta Giannini, Antonio Guaita and Cristina Cereda Tags: Research Source Type: research
Analysis and comparison of anti-RBD neutralizing antibodies from AZD-1222, Sputnik V, Sinopharm and Covaxin vaccines and its relationship with gender among health care workers
Vaccine efficiency has a significant role in the public perception of vaccination. The current study was designed to evaluate the efficacy of COVID-19 vaccines (AZD-1222, Sputnik-V, Sinopharm, and Covaxin) and... (Source: Immunity and Aging)
Source: Immunity and Aging - October 22, 2022 Category: Geriatrics Authors: Hamed Zare, Hadis Rezapour, Alireza Fereidouni, Saboura Nikpour, Sara Mahmoudzadeh, Simon G Royce and Mohammad Fereidouni Tags: Research Source Type: research
The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial
Vaccination is important in influenza prevention but the immune response wanes with age. The circadian nature of the immune system suggests that adjusting the time of vaccination may provide an opportunity to ... (Source: Immunity and Aging)
Source: Immunity and Aging - October 17, 2022 Category: Geriatrics Authors: Yihao Liu, Hui Zhang, Gang Yuan, Mi Yao, Bin Li, Jianying Chen, Yuling Fan, Ruohui Mo, Fenghua Lai, Xinwen Chen, Mengyuan Li, Binfeng Chen, Janet M. Lord, Sui Peng, KarKeung Cheng and Haipeng Xiao Tags: Research Source Type: research
Different phenotypes of microglia in animal models of Alzheimer disease
Microglia are immune-competent cells that are critically involved in maintaining normal brain function. A prominent characteristic of Alzheimer disease (AD) is microglial proliferation and activation concentra... (Source: Immunity and Aging)
Source: Immunity and Aging - October 8, 2022 Category: Geriatrics Authors: Yun Wei and Xianxiao Li Tags: Review Source Type: research
Composition of the infiltrating immune cells in the brain of healthy individuals: effect of aging
Immune cells infiltrating the central nervous system (CNS) are involved in the defense against invading microbes as well as in the pathogenesis of neuroinflammatory diseases. In these conditions, the presence ... (Source: Immunity and Aging)
Source: Immunity and Aging - October 8, 2022 Category: Geriatrics Authors: Tapio Nevalainen, Arttu Autio and Mikko Hurme Tags: Brief Report Source Type: research
Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias
Cognitive symptoms of major depressive disorder, such as negative cognitive bias, are more prevalent in women than in men. Cognitive bias involves pattern separation which requires hippocampal neurogenesis and... (Source: Immunity and Aging)
Source: Immunity and Aging - October 6, 2022 Category: Geriatrics Authors: Travis E. Hodges, Stephanie E. Lieblich, Rebecca K. Rechlin and Liisa A. M. Galea Tags: Research Source Type: research
The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China
Assessment of immune function is of key importance in recognition of disease or healthy status, which still faces challenge in clinical practice. We conducted a 10-center study to investigate lymphocyte parame... (Source: Immunity and Aging)
Source: Immunity and Aging - September 27, 2022 Category: Geriatrics Authors: Wei Liu, Jie Xu, Qiyao Pu, Mingwei Lan, Xiaolu Zhang, Yufeng Gu, Ying Wang, Fan Zheng, Jingjing Qian, Chunxue Fan, Jun Sui, Yanli Xu, Yongchen Zhang, Jing Luo, Xiangyang Lin, Shaorui Shi & hellip; Tags: Research Source Type: research
Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal
Monocytes are a heterogenous population of immune cells whose subsets and functions become substantially dysregulated with advanced age. Although much of our current understanding of the age-related changes in... (Source: Immunity and Aging)
Source: Immunity and Aging - September 14, 2022 Category: Geriatrics Authors: Ryan G. Snodgrass, Xiaowen Jiang and Charles B. Stephensen Tags: Research Source Type: research
Short-term zinc supplementation of zinc-deficient seniors counteracts CREM α - mediated IL-2 suppression
Aging is accompanied by a dramatic decline in the interleukin (IL)-2 production capacity of human immune cells, thus making seniors more susceptible to a variety of age-related diseases. A common cause of impa... (Source: Immunity and Aging)
Source: Immunity and Aging - August 30, 2022 Category: Geriatrics Authors: Bastian Robinson Baarz, Thea Laurentius, Jana Wolf, Inga Wessels, Leo Cornelius Bollheimer and Lothar Rink Tags: Research Source Type: research
Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons
Biological aging represents a loss of integrity and functionality of physiological systems over time. While associated with an enhanced risk of adverse outcomes such as hospitalization, disability and death fo... (Source: Immunity and Aging)
Source: Immunity and Aging - August 23, 2022 Category: Geriatrics Authors: Chris P. Verschoor, Daniel W. Belsky, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, Janet E. McElhaney and George A. Kuchel Tags: Research Source Type: research
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities
Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark of biological aging, has been associated with worse COVID-19 outcomes. We sought to determi... (Source: Immunity and Aging)
Source: Immunity and Aging - August 22, 2022 Category: Geriatrics Authors: Miriam Retuerto, Ana Lled ó, Beatriz Fernandez-Varas, Rosa Guerrero-López, Alicia Usategui, Antonio Lalueza, Rocío García-García, Esther Mancebo, Estela Paz-Artal, Leandro Sastre, Rosario Perona and José L. Pablos Tags: Research Source Type: research
Correction: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies
(Source: Immunity and Aging)
Source: Immunity and Aging - August 15, 2022 Category: Geriatrics Authors: Gemma Manich, Elisabet Aug é, Itsaso Cabezón, Mercè Pallàs, Jordi Vilaplana and Carme Pelegrí Tags: Correction Source Type: research
Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases
The world population is progressively ageing, assuming an enormous social and health challenge. As the world ages, neurodegenerative diseases are on the rise. Regarding the progressive nature of these diseases... (Source: Immunity and Aging)
Source: Immunity and Aging - August 11, 2022 Category: Geriatrics Authors: Adeleh Sahebnasagh, Samira Eghbali, Fatemeh Saghafi, Antoni Sureda and Razieh Avan Tags: Review Source Type: research
