Aging and CMV discordance are associated with increased immune diversity between monozygotic twins
Broadly, much of variance in immune system phenotype has been linked to the influence of non-heritable factors rather than genetics. In particular, two non-heritable factors: aging and human cytolomegavirus (C... (Source: Immunity and Aging)
Source: Immunity and Aging - January 18, 2021 Category: Geriatrics Authors: Zheng Yan, Holden T. Maecker, Petter Brodin, Unni C. Nygaard, Shu Chen Lyu, Mark M. Davis, Kari C. Nadeau and Sandra Andorf Tags: Research Source Type: research
Macrophage function in the elderly and impact on injury repair and cancer
Older age is associated with deteriorating health, including escalating risk of diseases such as cancer, and a diminished ability to repair following injury. This rise in age-related diseases/co-morbidities is... (Source: Immunity and Aging)
Source: Immunity and Aging - January 13, 2021 Category: Geriatrics Authors: L Duong, HG Radley, B Lee, DE Dye, FJ Pixley, MD Grounds, DJ Nelson and C Jackaman Tags: Review Source Type: research
Sex- and age ‐dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice
Physiological homeostasis decline, immunosenescence, and increased risk for multiple diseases, including neurodegeneration, are all hallmarks of ageing. Importantly, it is known that the ageing process is sex-... (Source: Immunity and Aging)
Source: Immunity and Aging - January 8, 2021 Category: Geriatrics Authors: Kelly B. Menees, Rachael H. Earls, Jaegwon Chung, Janna Jernigan, Nikolay M. Filipov, Jessica M. Carpenter and Jae-Kyung Lee Tags: Research Source Type: research
Gut microbiota as the key controllers of “healthy” aging of elderly people
Extrinsic factors, such as lifestyle and diet, are shown to be essential in the control of human healthy aging, and thus, longevity. They do so by targeting at least in part the gut microbiome, a collection of... (Source: Immunity and Aging)
Source: Immunity and Aging - January 5, 2021 Category: Geriatrics Authors: Emeline Ragonnaud and Arya Biragyn Tags: Review Source Type: research
Obesity and COVID-19: what makes obese host so vulnerable?
The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symp... (Source: Immunity and Aging)
Source: Immunity and Aging - January 4, 2021 Category: Geriatrics Authors: Sameer Mohammad, Rafia Aziz, Saeed Al Mahri, Shuja Shafi Malik, Esraa Haji, Altaf Husain Khan, Tanvir Saleem Khatlani and Abderrezak Bouchama Tags: Review Source Type: research
T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II
Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiolog... (Source: Immunity and Aging)
Source: Immunity and Aging - December 21, 2020 Category: Geriatrics Authors: Julia Sbierski-Kind, David Goldeck, Nikolaus Buchmann, Joachim Spranger, Hans-Dieter Volk, Elisabeth Steinhagen-Thiessen, Graham Pawelec, Ilja Demuth and Dominik Spira Tags: Research Source Type: research
Correction to: Human MDSCs derived from the bone marrow maintain their functional ability but have a reduced frequency of induction in the elderly compared to pediatric donors
An amendment to this paper has been published and can be accessed via the original article. (Source: Immunity and Aging)
Source: Immunity and Aging - November 25, 2020 Category: Geriatrics Authors: Sara Magri, Elena Masetto, Samantha Solito, Samuela Francescato, Elisa Belluzzi, Assunta Pozzuoli, Antonio Berizzi, Pietro Ruggieri and Susanna Mandruzzato Tags: Correction Source Type: research
Autoimmune hemolytic anemia: current knowledge and perspectives
Autoimmune hemolytic anemia (AIHA) is an acquired, heterogeneous group of diseases which includes warm AIHA, cold agglutinin disease (CAD), mixed AIHA, paroxysmal cold hemoglobinuria and atypical AIHA. Current... (Source: Immunity and Aging)
Source: Immunity and Aging - November 20, 2020 Category: Geriatrics Authors: Sylwia Sulimiera Michalak, Anna Olewicz-Gawlik, Joanna Rupa-Matysek, Edyta Wolny-Rokicka, El żbieta Nowakowska and Lidia Gil Tags: Review Source Type: research
Pathogen burden and leukocyte telomere length in the United States
Prior studies in humans have suggested that telomere shortening may be accelerated by infection, but research on multiple pathogens and use of large population-based study samples has been limited. We estimate... (Source: Immunity and Aging)
Source: Immunity and Aging - November 19, 2020 Category: Geriatrics Authors: Grace A. Noppert, Lydia Feinstein, Jennifer B. Dowd, Rebecca C. Stebbins, Emma Zang, Belinda L. Needham, Helen C. S. Meier, Amanda Simanek and Allison E. Aiello Tags: Research Source Type: research
Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination
Aging is characterized by a progressive decline in the capacity of the immune system to fight influenza virus infection and to respond to vaccination. Among the several factors involved, in addition to increas... (Source: Immunity and Aging)
Source: Immunity and Aging - November 19, 2020 Category: Geriatrics Authors: Daniela Frasca and Bonnie B. Blomberg Tags: Review Source Type: research
An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients
Since the COVID-19 outbreak an unprecedented challenge for healthcare systems around the world has been placed. In Cuba, the first case of COVID-19 was reported on March 11. Elderly with multiple comorbidities... (Source: Immunity and Aging)
Source: Immunity and Aging - November 14, 2020 Category: Geriatrics Authors: Danay Saavedra, Ana Laura A ñé-Kourí, Naivy Sánchez, Lázaro Manuel Filgueira, Julio Betancourt, Carlos Herrera, Leniel Manso, Elibet Chávez, Armando Caballero, Carlos Hidalgo, Geydi Lorenzo, Meylan Cepeda, Carmen Valenzuela, Mayra Ramos, Kalet León Tags: Research Source Type: research
Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis
Previously, we and others have reported higher populations of circulating neutrophils in patients with neovascular age-related macular degeneration (nAMD). Neutrophil gelatinase-associated lipocalin (NGAL, als... (Source: Immunity and Aging)
Source: Immunity and Aging - November 14, 2020 Category: Geriatrics Authors: Mei Chen, Nan Yang, Judith Lechner, Levente Toth, Ruth Hogg, Giuliana Silvestri, Usha Chakravarthy and Heping Xu Tags: Research Source Type: research
SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing
Infection with SARs-COV-2 displays increasing fatality with age and underlying co-morbidity, in particular, with markers of the metabolic syndrome and diabetes, which seems to be associated with a “cytokine st... (Source: Immunity and Aging)
Source: Immunity and Aging - November 9, 2020 Category: Geriatrics Authors: Alistair V. W. Nunn, Geoffrey W. Guy, Wolfgang Brysch, Stanley W. Botchway, Wayne Frasch, Edward J. Calabrese and Jimmy D. Bell Tags: Review Source Type: research
Effect of age and sex on immune checkpoint expression and kinetics in human T cells
Immune checkpoints are crucial molecules in maintaining a proper immune balance. Even though age and sex are known to have effects on the immune system, the interplay between age, sex and immune checkpoint exp... (Source: Immunity and Aging)
Source: Immunity and Aging - November 4, 2020 Category: Geriatrics Authors: Rosanne D. Reitsema, Rebeca Hid Cadena, Sander H. Nijhof, Wayel H. Abdulahad, Minke G. Huitema, Davy Paap, Elisabeth Brouwer, Annemieke M. H. Boots and Peter Heeringa Tags: Research Source Type: research
Emergence of T cell immunosenescence in diabetic chronic kidney disease
Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced... (Source: Immunity and Aging)
Source: Immunity and Aging - October 20, 2020 Category: Geriatrics Authors: Yen-Ling Chiu, Wan-Chuan Tsai, Ruo-Wei Hung, I-Yu Chen, Kai-Hsiang Shu, Szu-Yu Pan, Feng-Jung Yang, Te-Tien Ting, Ju-Ying Jiang, Yu-Sen Peng and Yi-Fang Chuang Tags: Research Source Type: research
