A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence
The aging lung is a complex process and influenced by various stressors, especially airborne pathogens and xenobiotics. Additionally, a lifetime exposure to antigens results in structural and functional change... (Source: Immunity and Aging)
Source: Immunity and Aging - November 6, 2023 Category: Geriatrics Authors: Meng He and J ürgen Borlak Tags: Research Source Type: research
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study
Immune responses to vaccination vary widely between individuals. The aim of this study was to identify health-related variables potentially underlying the antibody responses to SARS-CoV-2 vaccination in older ... (Source: Immunity and Aging)
Source: Immunity and Aging - October 25, 2023 Category: Geriatrics Authors: Yunus Kuijpers, H. Susan J. Picavet, Lia de Rond, Mary-l ène de Zeeuw-Brouwer, Ryanne Rutkens, Esther Gijsbers, Irene Slits, Peter Engelfriet, Anne-Marie Buisman and W. M. Monique Verschuren Tags: Research Source Type: research
Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF- κB, and FOXO3a signaling pathways
Sarcopenia is closely associated with gut dysbiosis. Probiotics alleviate gut dysbiosis. Therefore, we selected probiotics Lactobacillus paracasei P62 (Lp) and Bifidobacterium bifidum P61 (Bb), which suppressed m... (Source: Immunity and Aging)
Source: Immunity and Aging - October 23, 2023 Category: Geriatrics Authors: Ji-Su Baek, Yoon-Jung Shin, Xiaoyang Ma, Hee-Seo Park, Yun-Ha Hwang and Dong-Hyun Kim Tags: Research Source Type: research
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating... (Source: Immunity and Aging)
Source: Immunity and Aging - October 18, 2023 Category: Geriatrics Authors: Bernardo Abel Cedeno-Veloz, Luc ía Lozano-Vicario, Fabricio Zambom-Ferraresi, Joaquín Fernández-Irigoyen, Enrique Santamaría, Alba Rodríguez-García, Roman Romero-Ortuno, Jaime Mondragon-Rubio, Javier Ruiz-Ruiz, Robinson Ramírez-Vélez, Mikel Izquie Tags: Brief Report Source Type: research
Decoding the immune landscape following hip fracture in elderly patients: unveiling temporal dynamics through single-cell RNA sequencing
Hip fractures in the elderly have significant consequences, stemming from the initial trauma and subsequent surgeries. Hidden blood loss and stress due to concealed injury sites could impact the whole osteoimm... (Source: Immunity and Aging)
Source: Immunity and Aging - October 17, 2023 Category: Geriatrics Authors: Yining Lu, Yang Luo, Qi Zhang, Wei Chen, Ning Zhang, Ling Wang and Yingze Zhang Tags: Research Source Type: research
Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer ’s patients
Age-associated deterioration of the immune system contributes to a chronic low-grade inflammatory state known as “inflammaging” and is implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD). W... (Source: Immunity and Aging)
Source: Immunity and Aging - October 14, 2023 Category: Geriatrics Authors: Neriman Eren, Susanna Gerike, Berk Üsekes, Oliver Peters, Nicoleta-Carmen Cosma and Julian Hellmann-Regen Tags: Research Source Type: research
Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health
Increased age is a risk factor for the development and progression of retinal diseases including age-related macular degeneration (AMD). Understanding the changes that occur in the eye due to aging is importan... (Source: Immunity and Aging)
Source: Immunity and Aging - October 14, 2023 Category: Geriatrics Authors: Margarete M. Karg, May Moorefield, Emma Hoffmann, Hannah Philipose, Drenushe Krasniqi, Cindy Hoppe, Daisy Y. Shu, Shintaro Shirahama, Bruce R. Ksander and Magali Saint-Geniez Tags: Research Source Type: research
Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis
Adipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease associated with metabolic dysfunction and age-related mechanisms, wit... (Source: Immunity and Aging)
Source: Immunity and Aging - October 11, 2023 Category: Geriatrics Authors: L K Grun, R M Maurmann, J N Scholl, M E Foga ça, C R R Schmitz, C K Dias, J Gasparotto, A V Padoin, C C Mottin, F Klamt, F Figueiró, M H Jones, E C Filippi-Chiela, F C R Guma and F M Barbé-Tuana Tags: Research Source Type: research
Towards a better preclinical cancer model – human immune aging in humanized mice
Preclinical models are often used for cancer studies and evaluation of novel therapeutics. The relevance of these models has vastly improved with mice bearing a human immune system, especially in the context o... (Source: Immunity and Aging)
Source: Immunity and Aging - September 27, 2023 Category: Geriatrics Authors: Joel H. L. Tan, You Yi Hwang, Hui Xian Chin, Min Liu, Sue Yee Tan and Qingfeng Chen Tags: Research Source Type: research
Transcriptional characteristics and functional validation of three monocyte subsets during aging
Age-associated changes in immunity are inextricably linked to chronic inflammation and age-related diseases, the impact of aging on monocyte subsets is poorly understood. (Source: Immunity and Aging)
Source: Immunity and Aging - September 27, 2023 Category: Geriatrics Authors: Chen Wang, Yating Cheng, Boyu Li, Xueping Qiu, Hui Hu, Xiaokang Zhang, Zhibing Lu and Fang Zheng Tags: Research Source Type: research
Related factors of renal injury in primary Sj ögren's syndrome
Primary Sj ögren’s syndrome (pSS) is a common chronic systemic autoimmune disorder which primarily affects the exocrine glands. Patients may have extraglandular disease involving multiple organs, including the ... (Source: Immunity and Aging)
Source: Immunity and Aging - September 21, 2023 Category: Geriatrics Authors: Nan Duan, Zhiyan Li, Yong Fan, Yaping Jiang and Haixia Li Tags: Research Source Type: research
Association between body fat distribution and B-lymphocyte subsets in peripheral blood
Obesity is associated with chronic low-grade inflammation, which is underpinned by the presence of elevated levels of circulating proinflammatory cytokines in obese individuals. Due to the close relationship b... (Source: Immunity and Aging)
Source: Immunity and Aging - September 13, 2023 Category: Geriatrics Authors: Pia Prechtl, Timo Schmitz, Nicole Pochert, Claudia Traidl-Hoffmann, Jakob Linseisen, Christa Meisinger and Dennis Freuer Tags: Research Source Type: research
Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study
Neutrophils and lymphocytes represent the larger percentage of all white blood cells, they vary with age, with a progressive increase of the ratio in the first years of life, and then tend to remain at similar... (Source: Immunity and Aging)
Source: Immunity and Aging - September 4, 2023 Category: Geriatrics Authors: Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Eleonora Sparvieri, Domiziano Tarantino and Luigi Ferrucci Tags: Research Source Type: research
Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating na ïve CD8+ T cells in a Swedish middle-aged population
Fatty degeneration of thymus (or thymus involution) has long been considered a normal ageing process. However, there is emerging evidence that thymic involution is linked to T cell aging, chronic inflammation ... (Source: Immunity and Aging)
Source: Immunity and Aging - August 31, 2023 Category: Geriatrics Authors: M årten Sandstedt, Rosanna W S Chung, Camilla Skoglund, Anna K. Lundberg, Carl Johan Östgren, Jan Ernerudh and Lena Jonasson Tags: Research Source Type: research
Short-term intensive fasting enhances the immune function of red blood cells in humans
Fasting is known to influence the immune functions of leukocytes primarily by regulating their mobilization and redistribution between the bone marrow and the peripheral tissues or circulation, in particular v... (Source: Immunity and Aging)
Source: Immunity and Aging - August 30, 2023 Category: Geriatrics Authors: Yixuan Fang, Jiawei Qian, Li Xu, Wen Wei, Wenwen Bu, Suping Zhang, Yaqi Lv, Lei Li, Chen Zhao, Xueqin Gao, Yue Gu, Li Wang, Zixing Chen, Xiao Wang, Ruizhi Zhang, Youjia Xu & hellip; Tags: Research Source Type: research
