Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior
Horm Behav. 2023 Dec 22;159:105472. doi: 10.1016/j.yhbeh.2023.105472. Online ahead of print.ABSTRACTProper thyroid function is essential to the developing brain, including dopamine neuron differentiation, growth, and maintenance. Stress across the lifespan impacts thyroid hormone signaling and anxiety disorders and depression have been associated with thyroid dysfunction (both hypo- and hyper-active). However, less is known about how stress during postnatal development impacts thyroid function and related brain development. Our previous work in mice demonstrated that early-life stress (ELS) transiently impinged on expressi...
Source: Hormones and Behavior - December 23, 2023 Category: Endocrinology Authors: Shannon N Bennett Austin B Chang Forrest D Rogers Parker Jones Catherine Jensen Pe ña Source Type: research
Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior
Horm Behav. 2023 Dec 22;159:105472. doi: 10.1016/j.yhbeh.2023.105472. Online ahead of print.ABSTRACTProper thyroid function is essential to the developing brain, including dopamine neuron differentiation, growth, and maintenance. Stress across the lifespan impacts thyroid hormone signaling and anxiety disorders and depression have been associated with thyroid dysfunction (both hypo- and hyper-active). However, less is known about how stress during postnatal development impacts thyroid function and related brain development. Our previous work in mice demonstrated that early-life stress (ELS) transiently impinged on expressi...
Source: Hormones and Behavior - December 23, 2023 Category: Endocrinology Authors: Shannon N Bennett Austin B Chang Forrest D Rogers Parker Jones Catherine Jensen Pe ña Source Type: research
Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior
Horm Behav. 2023 Dec 22;159:105472. doi: 10.1016/j.yhbeh.2023.105472. Online ahead of print.ABSTRACTProper thyroid function is essential to the developing brain, including dopamine neuron differentiation, growth, and maintenance. Stress across the lifespan impacts thyroid hormone signaling and anxiety disorders and depression have been associated with thyroid dysfunction (both hypo- and hyper-active). However, less is known about how stress during postnatal development impacts thyroid function and related brain development. Our previous work in mice demonstrated that early-life stress (ELS) transiently impinged on expressi...
Source: Hormones and Behavior - December 23, 2023 Category: Endocrinology Authors: Shannon N Bennett Austin B Chang Forrest D Rogers Parker Jones Catherine Jensen Pe ña Source Type: research
Beyond the binary: Characterizing the relationships between sex and neuropeptide receptor binding density measures in the rat brain
Horm Behav. 2023 Dec 20;159:105471. doi: 10.1016/j.yhbeh.2023.105471. Online ahead of print.ABSTRACTSex differences exist in numerous parameters of the brain. Yet, sex-related factors are part of a large set of variables that interact to affect many aspects of brain structure and function. This raises questions regarding how to interpret findings of sex differences at the level of single brain measures and the brain as a whole. In the present study, we reanalyzed two datasets consisting of measures of oxytocin, vasopressin V1a, and mu opioid receptor binding densities in multiple brain regions in rats. At the level of sing...
Source: Hormones and Behavior - December 21, 2023 Category: Endocrinology Authors: Daphna Joel Caroline J Smith Alexa H Veenema Source Type: research
Beyond the binary: Characterizing the relationships between sex and neuropeptide receptor binding density measures in the rat brain
Horm Behav. 2023 Dec 20;159:105471. doi: 10.1016/j.yhbeh.2023.105471. Online ahead of print.ABSTRACTSex differences exist in numerous parameters of the brain. Yet, sex-related factors are part of a large set of variables that interact to affect many aspects of brain structure and function. This raises questions regarding how to interpret findings of sex differences at the level of single brain measures and the brain as a whole. In the present study, we reanalyzed two datasets consisting of measures of oxytocin, vasopressin V1a, and mu opioid receptor binding densities in multiple brain regions in rats. At the level of sing...
Source: Hormones and Behavior - December 21, 2023 Category: Endocrinology Authors: Daphna Joel Caroline J Smith Alexa H Veenema Source Type: research
Levonorgestrel maintains goal-directed behavior in habit-trained intact female rats
This study examined the effect of levonorgestrel (LNG), a widely used progestin-type contraceptive, on the development of habit in intact female rats. Rats were implanted with subcutaneous capsules that slowly released LNG over the course of the experiment or cholesterol-filled capsules. All female rats underwent operant training followed by reward devaluation to test for habit. One group of females was trained at a level that is sub-threshold to habit, while another group of females was trained to a level well over the habit threshold observed in intact females. The results reveal that all sub-threshold trained rats remai...
Source: Hormones and Behavior - December 15, 2023 Category: Endocrinology Authors: Sarah VonDoepp Zaidan Mohammed Russell Dougherty Ella Hilton-Vanosdall Sam Charette Adina Kraus Sarah Van Horn Adrianna Quirk Donna Toufexis Source Type: research
Levonorgestrel maintains goal-directed behavior in habit-trained intact female rats
This study examined the effect of levonorgestrel (LNG), a widely used progestin-type contraceptive, on the development of habit in intact female rats. Rats were implanted with subcutaneous capsules that slowly released LNG over the course of the experiment or cholesterol-filled capsules. All female rats underwent operant training followed by reward devaluation to test for habit. One group of females was trained at a level that is sub-threshold to habit, while another group of females was trained to a level well over the habit threshold observed in intact females. The results reveal that all sub-threshold trained rats remai...
Source: Hormones and Behavior - December 15, 2023 Category: Endocrinology Authors: Sarah VonDoepp Zaidan Mohammed Russell Dougherty Ella Hilton-Vanosdall Sam Charette Adina Kraus Sarah Van Horn Adrianna Quirk Donna Toufexis Source Type: research
Levonorgestrel maintains goal-directed behavior in habit-trained intact female rats
This study examined the effect of levonorgestrel (LNG), a widely used progestin-type contraceptive, on the development of habit in intact female rats. Rats were implanted with subcutaneous capsules that slowly released LNG over the course of the experiment or cholesterol-filled capsules. All female rats underwent operant training followed by reward devaluation to test for habit. One group of females was trained at a level that is sub-threshold to habit, while another group of females was trained to a level well over the habit threshold observed in intact females. The results reveal that all sub-threshold trained rats remai...
Source: Hormones and Behavior - December 15, 2023 Category: Endocrinology Authors: Sarah VonDoepp Zaidan Mohammed Russell Dougherty Ella Hilton-Vanosdall Sam Charette Adina Kraus Sarah Van Horn Adrianna Quirk Donna Toufexis Source Type: research
Levonorgestrel maintains goal-directed behavior in habit-trained intact female rats
This study examined the effect of levonorgestrel (LNG), a widely used progestin-type contraceptive, on the development of habit in intact female rats. Rats were implanted with subcutaneous capsules that slowly released LNG over the course of the experiment or cholesterol-filled capsules. All female rats underwent operant training followed by reward devaluation to test for habit. One group of females was trained at a level that is sub-threshold to habit, while another group of females was trained to a level well over the habit threshold observed in intact females. The results reveal that all sub-threshold trained rats remai...
Source: Hormones and Behavior - December 15, 2023 Category: Endocrinology Authors: Sarah VonDoepp Zaidan Mohammed Russell Dougherty Ella Hilton-Vanosdall Sam Charette Adina Kraus Sarah Van Horn Adrianna Quirk Donna Toufexis Source Type: research
Levonorgestrel maintains goal-directed behavior in habit-trained intact female rats
This study examined the effect of levonorgestrel (LNG), a widely used progestin-type contraceptive, on the development of habit in intact female rats. Rats were implanted with subcutaneous capsules that slowly released LNG over the course of the experiment or cholesterol-filled capsules. All female rats underwent operant training followed by reward devaluation to test for habit. One group of females was trained at a level that is sub-threshold to habit, while another group of females was trained to a level well over the habit threshold observed in intact females. The results reveal that all sub-threshold trained rats remai...
Source: Hormones and Behavior - December 15, 2023 Category: Endocrinology Authors: Sarah VonDoepp Zaidan Mohammed Russell Dougherty Ella Hilton-Vanosdall Sam Charette Adina Kraus Sarah Van Horn Adrianna Quirk Donna Toufexis Source Type: research
Impact of continuous testosterone exposure on reproductive physiology, activity, and pain-related behavior in young adult female rats
Horm Behav. 2023 Dec 12;158:105469. doi: 10.1016/j.yhbeh.2023.105469. Online ahead of print.ABSTRACTTestosterone may reduce pain in cisgender women and transgender men. Rodents can provide a useful model for investigating physiological effects of hormone therapy. To this end, continuous-release testosterone or blank (placebo) capsules were implanted s.c. into young adult female rats, and three weeks later rats were either ovariectomized or sham-ovariectomized. Testosterone treatment that mimicked previously reported endogenous levels in males eliminated estrous cycling and decreased uterine weight. Testosterone also signif...
Source: Hormones and Behavior - December 13, 2023 Category: Endocrinology Authors: Rebecca M Craft Christyne M Sewell Tessa M Taylor Mai Suong Vo Kristen Delevich Michael M Morgan Source Type: research
Impact of continuous testosterone exposure on reproductive physiology, activity, and pain-related behavior in young adult female rats
Horm Behav. 2023 Dec 12;158:105469. doi: 10.1016/j.yhbeh.2023.105469. Online ahead of print.ABSTRACTTestosterone may reduce pain in cisgender women and transgender men. Rodents can provide a useful model for investigating physiological effects of hormone therapy. To this end, continuous-release testosterone or blank (placebo) capsules were implanted s.c. into young adult female rats, and three weeks later rats were either ovariectomized or sham-ovariectomized. Testosterone treatment that mimicked previously reported endogenous levels in males eliminated estrous cycling and decreased uterine weight. Testosterone also signif...
Source: Hormones and Behavior - December 13, 2023 Category: Endocrinology Authors: Rebecca M Craft Christyne M Sewell Tessa M Taylor Mai Suong Vo Kristen Delevich Michael M Morgan Source Type: research
Impact of continuous testosterone exposure on reproductive physiology, activity, and pain-related behavior in young adult female rats
Horm Behav. 2023 Dec 12;158:105469. doi: 10.1016/j.yhbeh.2023.105469. Online ahead of print.ABSTRACTTestosterone may reduce pain in cisgender women and transgender men. Rodents can provide a useful model for investigating physiological effects of hormone therapy. To this end, continuous-release testosterone or blank (placebo) capsules were implanted s.c. into young adult female rats, and three weeks later rats were either ovariectomized or sham-ovariectomized. Testosterone treatment that mimicked previously reported endogenous levels in males eliminated estrous cycling and decreased uterine weight. Testosterone also signif...
Source: Hormones and Behavior - December 13, 2023 Category: Endocrinology Authors: Rebecca M Craft Christyne M Sewell Tessa M Taylor Mai Suong Vo Kristen Delevich Michael M Morgan Source Type: research
Early life adversity reduces affiliative behavior with a stressed cagemate and leads to sex-specific alterations in corticosterone responses in adult mice
Horm Behav. 2023 Dec 7;158:105464. doi: 10.1016/j.yhbeh.2023.105464. Online ahead of print.ABSTRACTExperiencing early life adversity (ELA) alters stress physiology and increases the risk for developing psychiatric disorders. The social environment can influence dynamics of stress responding and buffer and/or transfer stress across individuals. Yet, the impact of ELA on sensitivity to the stress of others and social behavior following stress is unknown. Here, to test the impact of ELA on social and physiological responses to stress, circulating blood corticosterone (CORT) and social behaviors were assessed in adult male and...
Source: Hormones and Behavior - December 9, 2023 Category: Endocrinology Authors: Jocelyn M Breton Zoey Cort Camila Demaestri Madalyn Critz Samuel Nevins Kendall Downend Dayshalis Ofray Russell D Romeo Kevin G Bath Source Type: research
Early life adversity reduces affiliative behavior with a stressed cagemate and leads to sex-specific alterations in corticosterone responses in adult mice
Horm Behav. 2023 Dec 7;158:105464. doi: 10.1016/j.yhbeh.2023.105464. Online ahead of print.ABSTRACTExperiencing early life adversity (ELA) alters stress physiology and increases the risk for developing psychiatric disorders. The social environment can influence dynamics of stress responding and buffer and/or transfer stress across individuals. Yet, the impact of ELA on sensitivity to the stress of others and social behavior following stress is unknown. Here, to test the impact of ELA on social and physiological responses to stress, circulating blood corticosterone (CORT) and social behaviors were assessed in adult male and...
Source: Hormones and Behavior - December 9, 2023 Category: Endocrinology Authors: Jocelyn M Breton Zoey Cort Camila Demaestri Madalyn Critz Samuel Nevins Kendall Downend Dayshalis Ofray Russell D Romeo Kevin G Bath Source Type: research
