Cardiac Resynchronization Therapy and Cardiac Contractility Modulation in Patients with Advanced Heart Failure
Cardiac resynchronization therapy is a well-established treatment of heart failure with reduced left ventricular ejection fraction and a wide QRS complex. Cardiac contractility modulation therapy is an emerging electrical treatment indicated for use in patients with symptomatic heart failure caused by moderate-to-severe systolic left ventricular dysfunction (left ventricular ejection fraction ranging from 25% to 45%), with no indication for cardiac resynchronization therapy. Cardiac contractility modulation therapy improves functional status, exercise capacity, quality of life, and possibly prevents hospital admissions in ...
Source: Heart Failure Clinics - September 10, 2021 Category: Cardiology Authors: William T. Abraham Source Type: research
Advanced Heart Failure in Special Population
Cardiomyopathies are a heterogeneous group of heart muscle diseases and an important cause of heart failure (HF) in young populations. The variety of causes, multiple underlying pathophysiological mechanisms, and different phenotypic expressions influence their presentation and response to treatment. Dilated cardiomyopathy is the most prevalent cause of HF. Advanced HF in hypertrophic, restrictive, and arrhythmogenic cardiomyopathies is rare, but its development portends a poor prognosis. The active phase of fulminant myocarditis may result in acute HF requiring advanced strategies to support the systemic circulation or ma...
Source: Heart Failure Clinics - September 10, 2021 Category: Cardiology Authors: Davide Stolfo, Valentino Collini, Gianfranco Sinagra Source Type: research
Treatment of Advanced Heart Failure —Focus on Transplantation and Durable Mechanical Circulatory Support
Heart transplantation (HTx) is the treatment of choice in patients with late-stage advanced heart failure (Advanced HF). Survival rates 1, 5, and 10 years after transplantation are 87%, 77%, and 57%, respectively, and the average life expectancy is 9.16 years. However, because of the donor organ shortage, waiting times often exceed life expectancy, resulting in a waiting list mortality of around 20%. This review aims to provide an overview of current standard, recent advances, and future developments in the treatment of Advanced HF with a focus on long-term mechanical circulatory support and HTx. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - September 10, 2021 Category: Cardiology Authors: Federica Guidetti, Mattia Arrigo, Michelle Frank, Fran Mikulicic, Mateusz Sokolski, Raed Aser, Markus J. Wilhelm, Andreas J. Flammer, Frank Ruschitzka, Stephan Winnik Source Type: research
Management of Advanced Heart Failure: The Science of Uncertainty and the Art of Probability
Management of patients with advanced heart failure is one of the most challenging clinical scenarios for the clinical cardiologist.1,2 To support clinicians in facing this challenge, we produced the current issue of Heart Failure Clinics. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - September 10, 2021 Category: Cardiology Authors: Giuseppe Pacileo, Francesco Grigioni, Daniele Masarone, Luciano Potena, Eduardo Bossone Tags: Preface Source Type: research
Advanced Heart Failure: From Pathophysiology to Clinical Management
HEART FAILURE CLINICS (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - September 10, 2021 Category: Cardiology Authors: Giuseppe Pacileo, Francesco Grigioni, Daniele Masarone, Luciano Potena Source Type: research
Copyright
ELSEVIER (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - September 10, 2021 Category: Cardiology Source Type: research
Contributors
EDUARDO BOSSONE, MD, PhD, FCCP, FESC, FACC (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - September 10, 2021 Category: Cardiology Source Type: research
Contents
Giuseppe Pacileo, Francesco Grigioni, Daniele Masarone, Luciano Potena and Eduardo Bossone (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - September 10, 2021 Category: Cardiology Source Type: research
Forthcoming Issues
Rare Cardiovascular Diseases (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - September 10, 2021 Category: Cardiology Source Type: research
Disease-modifier Drugs in Patients with Advanced Heart Failure
This article discusses the optimal use of disease-modifier drugs in patients with AdvHF as well as the possible usefulness of the new therapeutic opportunities. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - July 24, 2021 Category: Cardiology Authors: Massimo Iacoviello, Enrica Vitale, Maria Delia Corbo, Michele Correale, Natale Daniele Brunetti Source Type: research
Listing Criteria for Heart Transplant
Patients with advanced heart failure (AdHF) have a reduced quality of life and poor prognosis. A heart transplant (HT) is an effective treatment for such patients. Still, because of a shortage of donor organs, the final decision to place a patient without contraindications on the HT waiting list is based on detailed risk-benefit analysis. Cardiopulmonary exercise tests (CPETs) play a pivotal role in guiding selection in patients with AdHF considered for an HT. Furthermore, several validated multivariable predicting scores obtained through various techniques, including the CPETs, are available and part of the decision-makin...
Source: Heart Failure Clinics - July 24, 2021 Category: Cardiology Authors: Andrea Segreti, Giuseppe Verolino, Simone Pasquale Crispino, Piergiuseppe Agostoni Source Type: research
Congestion in Patients with Advanced Heart Failure
Heart failure (HF) is characterized by frequent hospital admissions due to acute decompensation and shortened life span with a progressive clinical course leading to an advanced stage where traditional therapies become ineffective. Due to aging of the population and improved therapies, only a small of proportion of patients with advanced HF are candidates for surgical treatments, such as mechanical circulatory support or heart transplantation. In most cases, prompt identification and management of congestion is paramount to improving symptoms and quality of life and avoiding progression to severe multiorgan dysfunction and...
Source: Heart Failure Clinics - July 22, 2021 Category: Cardiology Authors: Carlo Mario Lombardi, Giuliana Cimino, Pierpaolo Pellicori, Andrea Bonelli, Riccardo Maria Inciardi, Matteo Pagnesi, Daniela Tomasoni, Alice Ravera, Marianna Adamo, Valentina Carubelli, Marco Metra Source Type: research
Right Heart Catheterization in Patients with Advanced Heart Failure
Right heart catheterization is an established cornerstone of advanced heart failure management, as a clear understanding of the patient ’s hemodynamic status offers insight into diagnosis, prognosis, and management. In this review, the authors will describe the role of right heart catheterization in the diagnosis and management of shock, in the context of left ventricular assist devices, in the assessment of heart transplant candi dacy, and also explore future directions of implantable monitoring devices for pulmonary artery and left atrial pressure monitoring. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - July 22, 2021 Category: Cardiology Authors: Michelle M. Kittleson, Paola Prestinenzi, Luciano Potena Source Type: research
Pathophysiology of Advanced Heart Failure
This article discusses the most important clinical aspects of advanced HF pathophysiology. It presents the concept of neurohormonal activation and its deleterious effect on cardiovascular system and reflex control. The current theories regarding the role of inflammation, cytokine activation, and myocardial remodeling in HF progression are presented. Advanced HF is a multiorgan syndrome with interplay between cardiovascular system and other organs. The role of iron deficiency is also discussed. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - July 22, 2021 Category: Cardiology Authors: Jan Biegus, Piotr Niewinski, Krystian Josiak, Katarzyna Kulej, Barbara Ponikowska, Krzysztof Nowak, Robert Zymlinski, Piotr Ponikowski Source Type: research
Echocardiography in Advanced Heart Failure for Diagnosis, Management, and Prognosis
This article provides an overview of basic and emerging echocardiographic tools to assess patients with advanced heart failure. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - July 21, 2021 Category: Cardiology Authors: Enrico Melillo, Daniele Masarone, Jae K. Oh, Marina Verrengia, Fabio Valente, Rossella Vastarella, Ernesto Ammendola, Roberta Pacileo, Giuseppe Pacileo Source Type: research
