Phenomapping Heart Failure with Preserved Ejection Fraction Using Machine Learning Cluster Analysis
Heart failure with preserved ejection fraction (HFpEF) is characterized by a high rate of hospitalization and mortality (up to 84% at 5 years), which are similar to those observed for heart failure with reduced ejection fraction (HFrEF). These epidemiologic data claim for the development of specific and innovative therapies to reduce the burden of morbidity and mortality associated with this disease. Compared with HFrEF, which is due to a primary myocardial damage (eg ischemia, cardiomyopathies, toxicity), a heterogeneous etiologic background characterizes HFpEF. The authors discuss these phenotypes and specificities for...
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Authors: Elena Galli, Corentin Bourg, Wojciech Kosmala, Emmanuel Oger, Erwan Donal Source Type: research
Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction
In this article, the definition; mechanisms; diagnostic strategies, including scoring systems; treatments; prognosis; and future perspectives in heart failure with preserved ejection fraction with atrial fibrillation, which are common comorbid conditions, are reviewed thoroughly. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Authors: In-Cheol Kim Source Type: research
Current Prevalence, Incidence, and Outcomes of Heart Failure with Preserved Ejection Fraction
We describe the differences in the definitions of heart failure with preserved ejection fraction used in community-based studies, heart failure registries, and clinical trials. The worldwide prevalence of heart failure with preserved ejection fraction is approximately 2%; it is becoming the dominant form of heart failure owing to the aging population. The longitudinal trend of mortality in this disease is decreasing, and the risk of mortality is similar between heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Authors: Dong-Hyuk Cho, Byung-Su Yoo Source Type: research
Invasive Hemodynamics in Heart Failure with Preserved Ejection Fraction
This article attempts to summarize the importance of detecting pulmonary vascular remodeling in HFpEF using invasive hemodynamics. Incorporating newer invasive hemodynamic parameters such as diastolic pulmonary gradient, pulmonary arterial compliance, pulmonary vascular resistance, and pulmonary arterial pulsatility index may improve patient selection for studies used in defining advanced therapies and clinical outcomes. Profiling of patients using invasive hemodynamic parameters may lead to better patient selection for clinical research. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Authors: Nandini Nair Source Type: research
Exercise Intolerance in Heart Failure with Preserved Ejection Fraction
This article discusses the pathophysiology of exercise limitation in HFpEF, describes methods of determining exercise tolerance class, and evaluates prognostic implications and potential therapeutic strategies. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Authors: Andrea Salzano, Mariarosaria De Luca, Muhammad Zubair Israr, Giulia Crisci, Mohamed Eltayeb, Radek Debiec, Brigida Ranieri, Roberta D ’Assante, Salvatore Rega, Anna D’Agostino, Ciro Mauro, Iain B. Squire, Toru Suzuki, Eduardo Bossone, Marco Guazzi, Al Source Type: research
Renal Dysfunction and Heart Failure with Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) and chronic kidney disease (CKD) constitute a high-risk phenotype with significant morbidity and mortality and poor prognosis. Multiple proinflammatory comorbid conditions influence the pathogenesis of HFpEF and CKD. Renal dysfunction in HFpEF is a consequence of the complex interplay between hemodynamic factors, systemic congestion, inflammation, endothelial dysfunction, and neurohormonal mechanisms. In contrast to heart failure with reduced ejection fraction, there is a dearth of effective targeted therapies for HFpEF. Tailoring study design toward the different phen...
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Authors: Manjula G. Ananthram, Stephen S. Gottlieb Source Type: research
Comprehensive Assessment of Heart Failure with Preserved Ejection Fraction Using Cardiac MRI
Heart failure with preserved ejection fraction (HFpEF) burden is increasing. Its diagnostic process is challenging and imprecise due to absence of a single diagnostic marker, and the multiparametric echocardiography evaluation needed. Left ventricular (LV) ejection fraction (LVEF) is a limited marker of LV function; thus, allocating HF phenotypes based on LVEF can be misleading. HFpEF encompasses a broad spectrum of causes, and its diagnostic criteria give a central role to echocardiography, a first-line technique with inherent limitations related to ultrasound capabilities. Conversely, cardiac magnetic resonance provides ...
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Authors: Juli án Vega-Adauy, Ozge Ozden Tok, Ahmet Celik, Ahmet Barutcu, Mani A. Vannan Source Type: research
Heart Failure with Preserved Ejection Fraction: Current Opinion and Future Perspectives
With the advancement of medical technology and an increase in the elderly population, the number of patients with heart failure (HF) is increasing significantly with a subsequent increase in the socioeconomic burden.1 Approximately half of HF patients are known to have HF with preserved ejection fraction (HFpEF), linked to the rising life expectancy and various comorbidities, such as hypertension, diabetes mellitus, and chronic kidney disease.2 Due to the fact that the left ventricular ejection fraction (LVEF) is maintained in HFpEF patients, the prognosis is often falsely thought to be better than those with heart failure...
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Authors: Geu-Ru Hong, Mani A. Vannan, Eduardo Bossone Tags: Preface Source Type: research
Heart Failure with Preserved Ejection Fraction
HEART FAILURE CLINICS (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Authors: Geu-Ru Hong, Mani A. Vannan Source Type: research
Copyright
ELSEVIER (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Source Type: research
Contributors
EDUARDO BOSSONE, MD, PhD, FCCP, FESC, FACC (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Source Type: research
Contents
Geu-Ru Hong, Mani A. Vannan and Eduardo Bossone (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Source Type: research
Forthcoming Issues
Advanced Heart Failure: From Pathophysiology to Clinical Management (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - May 27, 2021 Category: Cardiology Source Type: research
Prevention of Coronary Artery Disease –Related Heart Failure: The Role of Computed Tomography Scan
During the past decade, coronary computed tomography angiography has emerged as the primary modality to noninvasively detect and rule out coronary artery disease. Therefore, this technique could play an important role in identifying patients at high risk of heart failure, considering the high prevalence of coronary artery disease in these patients. The latest technologies have also increased diagnostic accuracy, helping to close the gap with the other functional imaging modalities. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - March 3, 2021 Category: Cardiology Authors: Michele Fusaro, Giovanni Tessarin Source Type: research
Cardiac Resynchronization Therapy in Patients with Heart Failure
Cardiac resynchronization therapy (CRT) is an established treatment of patients with medically refractory, mild-to-severe systolic heart failure (HF), impaired left ventricular function, and wide QRS complex. The pathologic activation sequence observed in patients with abnormal QRS duration and morphology results in a dyssynchronous ventricular activation and contraction leading to cardiac remodeling, worsening systolic and diastolic function, and progressive HF. In this article, the authors aim to explore the current CRT literature, focusing their attentions on the promising innovation in this field. (Source: Heart Failure Clinics)
Source: Heart Failure Clinics - March 3, 2021 Category: Cardiology Authors: Giuseppe Palmiero, Maria Teresa Florio, Marta Rubino, Martina Nesti, Michal Marchel, Vincenzo Russo Source Type: research
