Pharmacological Treatment of ADHD in Addicted Patients: What Does the Literature Tell Us?
Conclusion: In reviewing these trials, possible explanations relating to the particular characteristics and problems of this complex patient group are discussed. Several factors, including ADHD symptom severity, psychiatric comorbidity, persistent drug use, choice of medication, and concomitant psychosocial intervention, influence study results. Taking these factors into account may improve the likelihood of detecting significant effects in future research, as the recent positive trials have indicated, and may help in the appropriate selection of pharmacotherapy in clinical practice. (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - March 1, 2017 Category: Psychiatry Tags: Reviews Source Type: research

Neurocircuits to Behavior: The New Revolution
No abstract available (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - March 1, 2017 Category: Psychiatry Tags: Advances in Psychiatric Research and Practice 25th Anniversary Brief Communication Source Type: research

A Determined Woman: Anxiety, Unresolved Mourning, and Capacity Assessment in Recurrent Pregnancy Loss
No abstract available (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2017 Category: Psychiatry Tags: Clinical Challenge Source Type: research

Differences in the Expression of Symptoms in Men Versus Women with Depression: A Systematic Review and Meta-analysis
Conclusions: Results are consistent with existing research on gender differences in the prevalence of substance use and mood disorders, and of their co-occurrence. They highlight the potential utility of screening for substance misuse, risk taking, and poor impulse control when assessing depression in men. Future research is warranted to clarify gender-specific presentations of depression and co-occurring symptoms. (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2017 Category: Psychiatry Tags: Reviews Source Type: research

Mental Health Problems in a Community After the Great East Japan Earthquake in 2011: A Systematic Review
Conclusion: Given that some mental health problems had not improved even two years after the disaster occurred, long-term mental health support is required for people in the affected area. Our finding that mental health problems seemed to be more severe in residents of Fukushima than among those in other areas suggests that residents in this prefecture require special care. (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2017 Category: Psychiatry Tags: Reviews Source Type: research

A Developmental Perspective on Social-Cognition Difficulties in Youth at Clinical High Risk for Psychosis
Learning objectives: After participating in this activity, learners should be better able to: • Evaluate the evolution of social cognitive abilities as a developmental process • Assess the evidence regarding social cognition difficulties in youth at clinical high risk for psychosis Individuals at clinical high risk (CHR) for psychosis exhibit a broad range of difficulties, including impaired social cognition, which may represent a target for early identification and intervention. Several studies have examined various domains of social cognition in CHR individuals. Most focus on adolescent and young adult populations...
Source: Harvard Review of Psychiatry - January 1, 2017 Category: Psychiatry Tags: Reviews Source Type: research

Celebrating the Harvard Review of Psychiatry’s 25th Year
No abstract available (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2017 Category: Psychiatry Tags: Editor in Chief's Introduction Source Type: research

Interacting Neural Processes of Feeding, Hyperactivity, Stress, Reward, and the Utility of the Activity-Based Anorexia Model of Anorexia Nervosa
Anorexia nervosa (AN) is a psychiatric illness with minimal effective treatments and a very high rate of mortality. Understanding the neurobiological underpinnings of the disease is imperative for improving outcomes and can be aided by the study of animal models. The activity-based anorexia rodent model (ABA) is the current best parallel for the study of AN. This review describes the basic neurobiology of feeding and hyperactivity seen in both ABA and AN, and compiles the research on the role that stress-response and reward pathways play in modulating the homeostatic drive to eat and to expend energy, which become dysfunct...
Source: Harvard Review of Psychiatry - November 1, 2016 Category: Psychiatry Tags: Neurobiology Source Type: research

Consideration of Clozapine and Gender-Affirming Medical Care for an HIV-Positive Person with Schizophrenia and Fluctuating Gender Identity
No abstract available (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - November 1, 2016 Category: Psychiatry Tags: Clinical Challenge Source Type: research

Predictive Neuroimaging Markers of Psychotherapy Response: A Systematic Review
Conclusion: While the extant data suggest avenues of further investigation, we are still far from being able to use these markers clinically. Future studies need to focus on longitudinal testing of potential markers, determining their prescriptive value and examining how they might be integrated with clinical factors. (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - November 1, 2016 Category: Psychiatry Tags: Reviews Source Type: research

The Differential Diagnosis and Treatment of Catatonia in Children and Adolescents
Conclusion: Pediatric catatonia is underdiagnosed and requires rapid evaluation and management. (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - November 1, 2016 Category: Psychiatry Tags: Reviews Source Type: research

Personality Disorders in DSM-5: A Commentary on the Perceived Process and Outcome of the Proposal of the Personality and Personality Disorders Work Group
Abstract: There has been much discussion and controversy concerning the process undertaken and the decisions made with respect to the Personality and Personality Disorders Work Group (PPDWG) proposal for DSM-5, as well as the rejection of the work group’s final proposal, by the American Psychiatric Association Board of Trustees. This commentary suggests that the way the PPDWG members were selected and the perceived secrecy associated with the PPDWG’s deliberations almost assured that, despite the hard work and good intentions of the group members, the proposal would raise controversy and could ultimately fail. This com...
Source: Harvard Review of Psychiatry - September 1, 2016 Category: Psychiatry Tags: Perspectives Source Type: research

Clinical Observations About the Potential Benefits and Pitfalls of Between-Session Contacts with Borderline Patients
This article also addresses the pitfalls of therapists being so accessible to patients. Both the benefits and pitfalls of intersession contact are illustrated using case vignettes. Assessing the function served by a patient’s contact in between sessions is an important way to determine whether such contact is a productive part of treatment. Recommendations are provided to avoid detrimental outcomes for both the therapist (therapist burnout) and the patient. (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - September 1, 2016 Category: Psychiatry Tags: Perspectives Source Type: research

“Good Enough” Psychiatric Residency Training in Borderline Personality Disorder: Challenges, Choice Points, and a Model Generalist Curriculum
Abstract: While the public health burden posed by borderline personality disorder (BPD) rivals that associated with other major mental illnesses, the prevailing disposition of psychiatrists toward the disorder remains characterized by misinformation, stigma, aversive attitudes, and insufficient familiarity with effective generalist treatments that can be delivered in nonspecialized health care settings. Residency training programs are well positioned to better equip the next generation of psychiatrists to address these issues, but no consensus or guidelines currently exist for what and how residents should be taught about ...
Source: Harvard Review of Psychiatry - September 1, 2016 Category: Psychiatry Tags: Perspectives Source Type: research

Borderline Personality Disorder in the Emergency Department: Good Psychiatric Management
This article presents an approach based on Good Psychiatric Management that can reduce negative reactions by ED staff and make ED visits more effective and less harmful. Relevant principles include psychoeducation, the reinforcement of the connection between symptoms and interpersonal stressors, and employment of an active, authentic therapeutic stance. Training ED staff in these principles could lead to attitudinal changes, reduced stigma, and potentially improved outcomes. (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - September 1, 2016 Category: Psychiatry Tags: Perspectives Source Type: research