Oxidative Stress, Inflammation, and Neuroprogression in Chronic PTSD
Posttraumatic stress disorder is a serious and often disabling syndrome that develops in response to a traumatic event. Many individuals who initially develop the disorder go on to experience a chronic form of the condition that in some cases can last for many years. Among these patients, psychiatric and medical comorbidities are common, including early onset of age-related conditions such as chronic pain, cardiometabolic disease, neurocognitive disorders, and dementia. The hallmark symptoms of posttraumatic stress—recurrent sensory-memory reexperiencing of the trauma(s)—are associated with concomitant activations of t...
Source: Harvard Review of Psychiatry - March 1, 2018 Category: Psychiatry Tags: Reviews Source Type: research
Living High and Feeling Low: Altitude, Suicide, and Depression
Learning objectives
After participating in this activity, learners should be better able to:
• Assess epidemiologic evidence that increased altitude of residence is linked to increased risk of depression and suicide
• Evaluate strategies to address hypoxia-related depression and suicidal ideation
Suicide and major depressive disorder (MDD) are complex conditions that almost certainly arise from the influences of many interrelated factors. There are significant regional variations in the rates of MDD and suicide in the United States, suggesting that sociodemographic and environmental conditions contribute. Here, we...
Source: Harvard Review of Psychiatry - March 1, 2018 Category: Psychiatry Tags: Reviews Source Type: research
Acknowledgments
No abstract available (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Acknowledgments Source Type: research
Mirtazapine Therapy for Posttraumatic Stress Disorder: Implications of Alpha-Adrenergic Pharmacology on the Startle Response
No abstract available (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Psychopharmacology Source Type: research
What’s in a Med Check? Unpacking the “Psychopharmacology” Encounter
No abstract available (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Clinical Challenge Source Type: research
Efficacy and Safety of Intensive Transcranial Magnetic Stimulation
This article reviews 16 articles to determine the safety and efficacy of such protocols. Intensive rTMS seems to be effective in various mental disorders. It appears to have, in general, the same adverse events as classic, long-term, daily rTMS, and it is largely well tolerated by the patients. One episode of depersonalization, one of increased suicidal thoughts, and two of induced mania were observed in the 16 studies reviewed. The advantages of intensive rTMS are in the possible acute effect of the stimulation and in the possible reduction in the time required to achieve remission in depression (and potentially other dis...
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Reviews Source Type: research
Suicidal Risk and Affective Temperaments, Evaluated with the TEMPS-A Scale: A Systematic Review
Conclusions
Affective temperaments, especially depressive and irritable, were strongly associated with suicidal risk, whereas hyperthymic temperament appeared to be protective. (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Reviews Source Type: research
Clinical and Environmental Risk Factors for Bipolar Disorder: Review of Prospective Studies
Learning objectives
After participating in this activity, learners should be better able to:
• Evaluate factors that have been identified in prospective studies as predicting the onset of bipolar disorder
The prodromal phase of bipolar disorder (BD) remains incompletely characterized, limiting early detection of BD and delaying interventions that might limit future morbidity and disability. Retrospective and family-risk studies have consistently found evidence of prodromal psychopathology in subjects later diagnosed with BD. Here, we review prospective studies of clinical risk factors and exposures identified before ...
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Reviews Source Type: research
Acknowledgments
No abstract available (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Acknowledgments Source Type: research
Mirtazapine Therapy for Posttraumatic Stress Disorder: Implications of Alpha-Adrenergic Pharmacology on the Startle Response
No abstract available (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Psychopharmacology Source Type: research
What’s in a Med Check? Unpacking the “Psychopharmacology” Encounter
No abstract available (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Clinical Challenge Source Type: research
Efficacy and Safety of Intensive Transcranial Magnetic Stimulation
This article reviews 16 articles to determine the safety and efficacy of such protocols. Intensive rTMS seems to be effective in various mental disorders. It appears to have, in general, the same adverse events as classic, long-term, daily rTMS, and it is largely well tolerated by the patients. One episode of depersonalization, one of increased suicidal thoughts, and two of induced mania were observed in the 16 studies reviewed. The advantages of intensive rTMS are in the possible acute effect of the stimulation and in the possible reduction in the time required to achieve remission in depression (and potentially other dis...
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Reviews Source Type: research
Suicidal Risk and Affective Temperaments, Evaluated with the TEMPS-A Scale: A Systematic Review
Conclusions
Affective temperaments, especially depressive and irritable, were strongly associated with suicidal risk, whereas hyperthymic temperament appeared to be protective. (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Reviews Source Type: research
Clinical and Environmental Risk Factors for Bipolar Disorder: Review of Prospective Studies
Learning objectives
After participating in this activity, learners should be better able to:
• Evaluate factors that have been identified in prospective studies as predicting the onset of bipolar disorder
The prodromal phase of bipolar disorder (BD) remains incompletely characterized, limiting early detection of BD and delaying interventions that might limit future morbidity and disability. Retrospective and family-risk studies have consistently found evidence of prodromal psychopathology in subjects later diagnosed with BD. Here, we review prospective studies of clinical risk factors and exposures identified before ...
Source: Harvard Review of Psychiatry - January 1, 2018 Category: Psychiatry Tags: Reviews Source Type: research
Heads Up: The Presentation of Schizoaffective Disorder in an Elite College Soccer Player with Prior Concussion
No abstract available (Source: Harvard Review of Psychiatry)
Source: Harvard Review of Psychiatry - November 1, 2017 Category: Psychiatry Tags: Clinical Challenge Source Type: research
