Clinical status of induction therapy incorporating a hypomethylating agent for newly diagnosed adult acute myeloid leukemia compared to the standard 7+3 regimen
Expert Rev Hematol. 2023 Sep 6. doi: 10.1080/17474086.2023.2256472. Online ahead of print.ABSTRACTINTRODUCTION: Cytarabine and anthracycline combination therapy (7 + 3 regimen) is the standard care for induction chemotherapy in adult patients with acute myeloid leukemia (AML). Although this intensive regimen achieves a high response rate, it is highly toxic, especially in elderly or frail patients. Hypomethylating agents approved initially for high-risk myelodysplastic syndrome had longer survival times than conventional care in elderly patients with newly diagnosed AML.AREAS COVERED: We summarize the latest information re...
Source: Expert Review of Hematology - September 6, 2023 Category: Hematology Authors: Akihiro Ohmoto Shigeo Fuji Source Type: research
Modifiable lifestyle risk factors and survival after diagnosis with multiple myeloma
CONCLUSIONS: Our findings support established recommendations for healthy diets and against smoking. Higher quality diet, as measured by the AHEI, may improve survival post diagnosis with MM.PMID:37667498 | DOI:10.1080/17474086.2023.2255747 (Source: Expert Review of Hematology)
Source: Expert Review of Hematology - September 5, 2023 Category: Hematology Authors: Simon Cheah Julie K Bassett Fiona J Bruinsma John Hopper Harindra Jayasekara Doug Joshua Robert J MacInnis H Miles Prince Melissa C Southey Claire M Vajdic Marina T van Leeuwen Nicole Wong Doo Simon J Harrison Dallas R English Graham G Giles Roger L Milne Source Type: research
Immune thrombocytopenia: a review on the pathogenetic role of immune cells
Expert Rev Hematol. 2023 Sep 5. doi: 10.1080/17474086.2023.2255750. Online ahead of print.ABSTRACTINTRODUCTION: Immune thrombocytopenia [ITP] is a common bleeding disorder with an isolated platelet count of less than 100 × 109/L.AREAS COVERED: Relevant literature from 2003 to 2022 was retrieved and reviewed from the Google Scholar search engine and PubMed database. Antibodies produced by autoreactive B lymphocytes and the phagocytic function of macrophages are considered the most critical factors in platelet destruction. Also, macrophages present the antigen to T lymphocytes and activate them. Follicular helper T-cells [T...
Source: Expert Review of Hematology - September 5, 2023 Category: Hematology Authors: Forogh Nokhostin Fatemeh Bakhshpour Seyed Mohammad Sadegh Pezeshki Reyhane Khademi Najmaldin Saki Source Type: research
Modifiable lifestyle risk factors and survival after diagnosis with multiple myeloma
CONCLUSIONS: Our findings support established recommendations for healthy diets and against smoking. Higher quality diet, as measured by the AHEI, may improve survival post diagnosis with MM.PMID:37667498 | DOI:10.1080/17474086.2023.2255747 (Source: Expert Review of Hematology)
Source: Expert Review of Hematology - September 5, 2023 Category: Hematology Authors: Simon Cheah Julie K Bassett Fiona J Bruinsma John Hopper Harindra Jayasekara Doug Joshua Robert J MacInnis H Miles Prince Melissa C Southey Claire M Vajdic Marina T van Leeuwen Nicole Wong Doo Simon J Harrison Dallas R English Graham G Giles Roger L Milne Source Type: research
