Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system
Drug Deliv. 2024 Dec;31(1):2300945. doi: 10.1080/10717544.2023.2300945. Epub 2024 Feb 16.ABSTRACTBurn injuries are prevalent and life-threatening forms that contribute significantly to mortality rates due to associated wound infections. The management of burn wounds presents substantial challenges. Hydrogel exhibits tremendous potential as an ideal alternative to traditional wound dressings such as gauze. This is primarily attributed to its three-dimensional (3D) crosslinked polymer network, which possesses a high water content, fostering a moist environment that supports effective burn wound healing. Additionally, hydroge...
Source: Drug Delivery - February 17, 2024 Category: Drugs & Pharmacology Authors: MeeiChyn Goh Meng Du Wang Rui Peng Phei Er Saw Zhiyi Chen Source Type: research
A mini-review on gene delivery technique using nanoparticles-mediated photoporation induced by nanosecond pulsed laser
Drug Deliv. 2024 Dec;31(1):2306231. doi: 10.1080/10717544.2024.2306231. Epub 2024 Jan 21.ABSTRACTNanosecond pulsed laser induced photoporation has gained increasing attention from scholars as an effective method for delivering the membrane-impermeable extracellular materials into living cells. Compared with femtosecond laser, nanosecond laser has the advantage of high throughput and low costs. It also has a higher delivery efficiency than continuous wave laser. Here, we provide an extensive overview of current status of nanosecond pulsed laser induced photoporation, covering the photoporation mechanism as well as various f...
Source: Drug Delivery - January 21, 2024 Category: Drugs & Pharmacology Authors: Xiaofan Du Meng Zhao Le Jiang Lihui Pang Jing Wang Yi Lv Cuiping Yao Rongqian Wu Source Type: research
Breaking boundaries: the advancements in transdermal delivery of antibiotics
In conclusion, the transdermal delivery systems could be a promising method for delivering antibiotics that have the potential to improve patient outcomes and enhance the efficacy of drugs. Further research and development are still needed to explore the potential of delivering more antibiotic drugs by using various transdermal drug delivery approaches.PMID:38241087 | PMC:PMC10802811 | DOI:10.1080/10717544.2024.2304251 (Source: Drug Delivery)
Source: Drug Delivery - January 19, 2024 Category: Drugs & Pharmacology Authors: Ahlam Zaid Alkilani Rania Hamed Batool Musleh Zaina Sharaire Source Type: research
Incompatibility of antimalarial drugs: challenges in formulating combination products for malaria
In this study, it was hypothesized that the use of fatty acids could lead to enhanced solubility in lipid formulation. Addition of the fatty acid solved the dissolution challenges, making LF soluble for over a year at room temperature (21-23 °C); but further research is needed to test the mechanism of action of the fatty acid. In addition, design of experiments (MODDE® 13) revealed that the amount of fatty acid in the formulation was the only significant factor for LF precipitation.PMID:38180033 | PMC:PMC10773615 | DOI:10.1080/10717544.2023.2299594 (Source: Drug Delivery)
Source: Drug Delivery - January 5, 2024 Category: Drugs & Pharmacology Authors: Ellen K G Mhango Benjamin R Sveinbjornsson Bergthora S Snorradottir Sveinbjorn Gizurarson Source Type: research
Incompatibility of antimalarial drugs: challenges in formulating combination products for malaria
In this study, it was hypothesized that the use of fatty acids could lead to enhanced solubility in lipid formulation. Addition of the fatty acid solved the dissolution challenges, making LF soluble for over a year at room temperature (21-23 °C); but further research is needed to test the mechanism of action of the fatty acid. In addition, design of experiments (MODDE® 13) revealed that the amount of fatty acid in the formulation was the only significant factor for LF precipitation.PMID:38180033 | DOI:10.1080/10717544.2023.2299594 (Source: Drug Delivery)
Source: Drug Delivery - January 5, 2024 Category: Drugs & Pharmacology Authors: Ellen K G Mhango Benjamin R Sveinbjornsson Bergthora S Snorradottir Sveinbjorn Gizurarson Source Type: research
Biodegradable polymeric insulin microneedles - a design and materials perspective review
Drug Deliv. 2024 Dec;31(1):2296350. doi: 10.1080/10717544.2023.2296350. Epub 2023 Dec 26.ABSTRACTMicroneedle (MN) delivery devices are more accepted by people than regular traditional needle injections (e.g. vaccination) due to their simplicity and adaptability. Thus, patients of chronic diseases like diabetes look for alternative pain-free treatment regimens circumventing regular subcutaneous injections. Insulin microneedles (INS-MNs) are a thoughtfully researched topic (1) to overcome needle phobia in patients, (2) for controlled delivery of the peptide, (3) decreasing the frequency of drug administration, (4) to ease th...
Source: Drug Delivery - December 26, 2023 Category: Drugs & Pharmacology Authors: Melbha Starlin Chellathurai Syed Mahmood Zarif Mohamed Sofian Cheng Wan Hee Ramkanth Sundarapandian Haja Nazeer Ahamed C S Kandasamy Ayah R Hilles Najihah Mohd Hashim Ashok Kumar Janakiraman Source Type: research
Multiple delivery strategies of nanocarriers for myocardial ischemia-reperfusion injury: current strategies and future prospective
This article reviews current drug delivery systems used for MI/RI, aiming to offer a fresh perspective on treating this disease.PMID:38147501 | PMC:PMC10763895 | DOI:10.1080/10717544.2023.2298514 (Source: Drug Delivery)
Source: Drug Delivery - December 26, 2023 Category: Drugs & Pharmacology Authors: Shengnan Li Fengmei Li Yan Wang Wenqun Li Junyong Wu Xiongbin Hu Tiantian Tang Xinyi Liu Source Type: research
Biodegradable polymeric insulin microneedles - a design and materials perspective review
Drug Deliv. 2024 Dec;31(1):2296350. doi: 10.1080/10717544.2023.2296350. Epub 2023 Dec 26.ABSTRACTMicroneedle (MN) delivery devices are more accepted by people than regular traditional needle injections (e.g. vaccination) due to their simplicity and adaptability. Thus, patients of chronic diseases like diabetes look for alternative pain-free treatment regimens circumventing regular subcutaneous injections. Insulin microneedles (INS-MNs) are a thoughtfully researched topic (1) to overcome needle phobia in patients, (2) for controlled delivery of the peptide, (3) decreasing the frequency of drug administration, (4) to ease th...
Source: Drug Delivery - December 26, 2023 Category: Drugs & Pharmacology Authors: Melbha Starlin Chellathurai Syed Mahmood Zarif Mohamed Sofian Cheng Wan Hee Ramkanth Sundarapandian Haja Nazeer Ahamed C S Kandasamy Ayah R Hilles Najihah Mohd Hashim Ashok Kumar Janakiraman Source Type: research
