Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions
Drug Deliv. 2023 Dec;30(1):2254530. doi: 10.1080/10717544.2023.2254530.ABSTRACTOral cancer is one of the leading causes of death worldwide. Oral precancerous lesions (OPL) are the precursors of oral cancer, with varying degrees of progression. Tetrahydrocurcumin (THC) is a major metabolite of curcumin with superior anticancer properties against various types of cancer. However, THC's clinical outcome is limited by its poor aqueous solubility. Herein, we developed novel mucoadhesive biopolymer-based composite sponges for buccal delivery of THC, exploiting nanotechnology and mucoadhesion for efficient prevention and treatmen...
Source: Drug Delivery - September 5, 2023 Category: Drugs & Pharmacology Authors: Shimaa A Elbanna Heba M K Ebada Ossama Y Abdallah Marwa M Essawy Hend M Abdelhamid Hebatallah S Barakat Source Type: research
Kartogenin delivery systems for biomedical therapeutics and regenerative medicine
Drug Deliv. 2023 Dec;30(1):2254519. doi: 10.1080/10717544.2023.2254519.ABSTRACTKartogenin, a small and heterocyclic molecule, has emerged as a promising therapeutic agent for incorporation into biomaterials, owing to its unique physicochemical and biological properties. It holds potential for the regeneration of cartilage-related tissues in various common conditions and injuries. Achieving sustained release of kartogenin through appropriate formulation and efficient delivery systems is crucial for modulating cell behavior and tissue function. This review provides an overview of cutting-edge kartogenin-functionalized biomat...
Source: Drug Delivery - September 4, 2023 Category: Drugs & Pharmacology Authors: Peixing Chen Xiaoling Liao Source Type: research
Kartogenin delivery systems for biomedical therapeutics and regenerative medicine
Drug Deliv. 2023 Dec;30(1):2254519. doi: 10.1080/10717544.2023.2254519.ABSTRACTKartogenin, a small and heterocyclic molecule, has emerged as a promising therapeutic agent for incorporation into biomaterials, owing to its unique physicochemical and biological properties. It holds potential for the regeneration of cartilage-related tissues in various common conditions and injuries. Achieving sustained release of kartogenin through appropriate formulation and efficient delivery systems is crucial for modulating cell behavior and tissue function. This review provides an overview of cutting-edge kartogenin-functionalized biomat...
Source: Drug Delivery - September 4, 2023 Category: Drugs & Pharmacology Authors: Peixing Chen Xiaoling Liao Source Type: research
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model
Drug Deliv. 2023 Dec;30(1):2251720. doi: 10.1080/10717544.2023.2251720.ABSTRACTHerein we designed, optimized, and characterized the Metformin Hydrochloride Transethosomes (MTF-TES) and incorporate them into Chitosan gel to develop Metformin Hydrochloride loaded Transethosomal gel (MTF-TES gel) that provides a sustained release, improved transdermal flux and improved antidiabetic response of MTF. Design Expert® software (Ver. 12, Stat-Ease, USA) was applied for the statistical optimization of MTF-TES. The formulation with Mean Particle Size Distribution (MPSD) of 165.4 ± 2.3 nm, Zeta Potential (ZP) of -21.2 ± 1.9 mV, Pol...
Source: Drug Delivery - August 31, 2023 Category: Drugs & Pharmacology Authors: Kainat Nousheen Fakhar Ud Din Humzah Jamshaid Rabia Afza Saif Ullah Khan Maimoona Malik Zakir Ali Sibgha Batool Alam Zeb Abid Mehmood Yousaf Ali H Almari Saud Alqahtani Salman Khan Gul Majid Khan Source Type: research
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model
Drug Deliv. 2023 Dec;30(1):2251720. doi: 10.1080/10717544.2023.2251720.ABSTRACTHerein we designed, optimized, and characterized the Metformin Hydrochloride Transethosomes (MTF-TES) and incorporate them into Chitosan gel to develop Metformin Hydrochloride loaded Transethosomal gel (MTF-TES gel) that provides a sustained release, improved transdermal flux and improved antidiabetic response of MTF. Design Expert® software (Ver. 12, Stat-Ease, USA) was applied for the statistical optimization of MTF-TES. The formulation with Mean Particle Size Distribution (MPSD) of 165.4 ± 2.3 nm, Zeta Potential (ZP) of -21.2 ± 1.9 mV, Pol...
Source: Drug Delivery - August 31, 2023 Category: Drugs & Pharmacology Authors: Kainat Nousheen Fakhar Ud Din Humzah Jamshaid Rabia Afza Saif Ullah Khan Maimoona Malik Zakir Ali Sibgha Batool Alam Zeb Abid Mehmood Yousaf Ali H Almari Saud Alqahtani Salman Khan Gul Majid Khan Source Type: research
Topically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia
Drug Deliv. 2023 Dec;30(1):2245169. doi: 10.1080/10717544.2023.2245169.ABSTRACTPhototherapy is a conventional antipsoriatic approach based on oxygen-relevant generation of oxidative stress to inhibit keratinocyte hyperproliferation. However, this therapy can be restricted due to local hypoxia in psoriatic lesions. The generation of alkyl radicals is oxygen-independent and suppresses hyperproliferation. Herein, we established alkyl radical-based therapy to treat psoriatic hyperplasia. Because alkyl radicals are short-lived compounds, we loaded 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH) as a precursor o...
Source: Drug Delivery - August 16, 2023 Category: Drugs & Pharmacology Authors: G R Nirmal Chia-Chih Liao Zih-Chan Lin Abdullah Alshetaili Erica Hwang Shih-Chun Yang Jia-You Fang Source Type: research
