Novel nano-carriers with N-formylmethionyl-leucyl-phenylalanine-modified liposomes improve effects of C16-angiopoietin 1 in acute animal model of multiple sclerosis
This study indicated that the fMLP-nano-carrier C + A could attenuate inflammation-related pathological changes in EAE and may be a potential therapeutic strategy for the treatment of MS and EAE.PMID:37545034 | DOI:10.1080/10717544.2023.2241664 (Source: Drug Delivery)
Source: Drug Delivery - August 7, 2023 Category: Drugs & Pharmacology Authors: Xiao-Xiao Fu Han Qu Jing Wang Hua-Ying Cai Hong Jiang Hao-Hao Chen Shu Han Source Type: research
Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, < em > in-vitro < /em > , < em > in silico < /em > , and < em > in-vivo < /em > study
Drug Deliv. 2023 Dec;30(1):2241665. doi: 10.1080/10717544.2023.2241665.ABSTRACTCanagliflozin (CFZ) is a sodium-glucose cotransporter-2 inhibitor (SGLT2) that lowers albuminuria in type-2 diabetic patients, cardiovascular, kidney, and liver disease. CFZ is classified as class IV in the Biopharmaceutical Classification System (BCS) and is characterized by low permeability, solubility, and bioavailability, most likely attributed to hepatic first-pass metabolism. Nanocrystal-based sublingual formulations were developed in the presence of sodium caprate, as a wetting agent, and as a permeability enhancer. This formulation is su...
Source: Drug Delivery - August 4, 2023 Category: Drugs & Pharmacology Authors: Sammar Fathy Elhabal Mohamed A El-Nabarawi Nashwa Abdelaal Mohamed Fathi Mohamed Elrefai Shrouk A Ghaffar Mohamed Mansour Khalifa Passant M Mohie Dania S Waggas Ahmed Mohsen Elsaid Hamdan Samar Zuhair Alshawwa Essa M Saied Nahla A Elzohairy Tayseer Elnawa Source Type: research
Sustained delivery of triamcinolone acetonide from a thermosensitive microemulsion gel system for the treatment of sensorineural hearing loss
Drug Deliv. 2023 Dec;30(1):2242003. doi: 10.1080/10717544.2023.2242003.ABSTRACTIntratympanic administration for the delivery of steroids has been extensively studied but limited because of low permeability of the drug through the row window membrane. Here, to effectively deliver poorly soluble triamcinolone acetonide (TA), microemulsions (ME) were prepared from Capmul MCM (oil), Cremophor RH40 (surfactant), and tetraglycol (cosurfactant) based on solubility studies, emulsifying ability test, and pseudoternary phase diagrams. Microemulsion gel (MEG) was prepared by mixing TA-ME with a poloxamer hydrogel base. The physicoche...
Source: Drug Delivery - August 4, 2023 Category: Drugs & Pharmacology Authors: Thu Nhan Nguyen So-Yeol Yoo Warisraporn Tangchang Jae-Young Lee Hwa-Young Son Jeong-Sook Park Source Type: research
Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, < em > in-vitro < /em > , < em > in silico < /em > , and < em > in-vivo < /em > study
Drug Deliv. 2023 Dec;30(1):2241665. doi: 10.1080/10717544.2023.2241665.ABSTRACTCanagliflozin (CFZ) is a sodium-glucose cotransporter-2 inhibitor (SGLT2) that lowers albuminuria in type-2 diabetic patients, cardiovascular, kidney, and liver disease. CFZ is classified as class IV in the Biopharmaceutical Classification System (BCS) and is characterized by low permeability, solubility, and bioavailability, most likely attributed to hepatic first-pass metabolism. Nanocrystal-based sublingual formulations were developed in the presence of sodium caprate, as a wetting agent, and as a permeability enhancer. This formulation is su...
Source: Drug Delivery - August 4, 2023 Category: Drugs & Pharmacology Authors: Sammar Fathy Elhabal Mohamed A El-Nabarawi Nashwa Abdelaal Mohamed Fathi Mohamed Elrefai Shrouk A Ghaffar Mohamed Mansour Khalifa Passant M Mohie Dania S Waggas Ahmed Mohsen Elsaid Hamdan Samar Zuhair Alshawwa Essa M Saied Nahla A Elzohairy Tayseer Elnawa Source Type: research
Sustained delivery of triamcinolone acetonide from a thermosensitive microemulsion gel system for the treatment of sensorineural hearing loss
Drug Deliv. 2023 Dec;30(1):2242003. doi: 10.1080/10717544.2023.2242003.ABSTRACTIntratympanic administration for the delivery of steroids has been extensively studied but limited because of low permeability of the drug through the row window membrane. Here, to effectively deliver poorly soluble triamcinolone acetonide (TA), microemulsions (ME) were prepared from Capmul MCM (oil), Cremophor RH40 (surfactant), and tetraglycol (cosurfactant) based on solubility studies, emulsifying ability test, and pseudoternary phase diagrams. Microemulsion gel (MEG) was prepared by mixing TA-ME with a poloxamer hydrogel base. The physicoche...
Source: Drug Delivery - August 4, 2023 Category: Drugs & Pharmacology Authors: Thu Nhan Nguyen So-Yeol Yoo Warisraporn Tangchang Jae-Young Lee Hwa-Young Son Jeong-Sook Park Source Type: research
Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, < em > in-vitro < /em > , < em > in silico < /em > , and < em > in-vivo < /em > study
Drug Deliv. 2023 Dec;30(1):2241665. doi: 10.1080/10717544.2023.2241665.ABSTRACTCanagliflozin (CFZ) is a sodium-glucose cotransporter-2 inhibitor (SGLT2) that lowers albuminuria in type-2 diabetic patients, cardiovascular, kidney, and liver disease. CFZ is classified as class IV in the Biopharmaceutical Classification System (BCS) and is characterized by low permeability, solubility, and bioavailability, most likely attributed to hepatic first-pass metabolism. Nanocrystal-based sublingual formulations were developed in the presence of sodium caprate, as a wetting agent, and as a permeability enhancer. This formulation is su...
Source: Drug Delivery - August 4, 2023 Category: Drugs & Pharmacology Authors: Sammar Fathy Elhabal Mohamed A El-Nabarawi Nashwa Abdelaal Mohamed Fathi Mohamed Elrefai Shrouk A Ghaffar Mohamed Mansour Khalifa Passant M Mohie Dania S Waggas Ahmed Mohsen Elsaid Hamdan Samar Zuhair Alshawwa Essa M Saied Nahla A Elzohairy Tayseer Elnawa Source Type: research
Sustained delivery of triamcinolone acetonide from a thermosensitive microemulsion gel system for the treatment of sensorineural hearing loss
Drug Deliv. 2023 Dec;30(1):2242003. doi: 10.1080/10717544.2023.2242003.ABSTRACTIntratympanic administration for the delivery of steroids has been extensively studied but limited because of low permeability of the drug through the row window membrane. Here, to effectively deliver poorly soluble triamcinolone acetonide (TA), microemulsions (ME) were prepared from Capmul MCM (oil), Cremophor RH40 (surfactant), and tetraglycol (cosurfactant) based on solubility studies, emulsifying ability test, and pseudoternary phase diagrams. Microemulsion gel (MEG) was prepared by mixing TA-ME with a poloxamer hydrogel base. The physicoche...
Source: Drug Delivery - August 4, 2023 Category: Drugs & Pharmacology Authors: Thu Nhan Nguyen So-Yeol Yoo Warisraporn Tangchang Jae-Young Lee Hwa-Young Son Jeong-Sook Park Source Type: research
Sustained release gel (polymer-free) of itraconazole-loaded microemulsion for oral candidiasis treatment: time-kill kinetics and cellular uptake
Drug Deliv. 2023 Dec;30(1):2234099. doi: 10.1080/10717544.2023.2234099.ABSTRACTItraconazole (ICZ) was prepared in a self-microemulsifying (SM) gel. This gel was intended for use in the oral mucosa, where low volume and flow of saliva result in limited solubility and absorption of drugs that are poorly water-soluble. The drug-loaded gel formulation (ICZ-SM) was selected as a clear solution in the ternary phase diagram to improve the solubility of ICZ. Seven ratios (S1-S7) were prepared by mixing polyoxyl 35 castor oils (P35), a medium chain with a blend of mono-, di-, and triglycerides (MCT), and water. Phase separation of ...
Source: Drug Delivery - July 14, 2023 Category: Drugs & Pharmacology Authors: Sukannika Tubtimsri Yotsanan Weerapol Source Type: research
