Lipid raft disruption as an opportunity for peripheral analgesia
Curr Opin Pharmacol. 2024 Jan 29;75:102432. doi: 10.1016/j.coph.2024.102432. Online ahead of print.ABSTRACTChronic pain conditions are unmet medical needs, since the available drugs, opioids, non-steroidal anti-inflammatory/analgesic drugs and adjuvant analgesics do not provide satisfactory therapeutic effect in a great proportion of patients. Therefore, there is an urgent need to find novel targets and novel therapeutic approaches that differ from classical pharmacological receptor antagonism. Most ion channels and receptors involved in pain sensation and processing such as Transient Receptor Potential ion channels, opioi...
Source: Current Opinion in Pharmacology - January 30, 2024 Category: Drugs & Pharmacology Authors: Andrea Kinga Nehr-Majoros Ágnes Király Zsuzsanna Helyes Éva Szőke Source Type: research
Editorial overview: Endocrine and metabolic diseases (2023)
Curr Opin Pharmacol. 2024 Jan 29;75:102436. doi: 10.1016/j.coph.2024.102436. Online ahead of print.NO ABSTRACTPMID:38290403 | DOI:10.1016/j.coph.2024.102436 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - January 30, 2024 Category: Drugs & Pharmacology Authors: Ivana Bjelobaba Stephanie Constantin Source Type: research
Lipid raft disruption as an opportunity for peripheral analgesia
Curr Opin Pharmacol. 2024 Jan 29;75:102432. doi: 10.1016/j.coph.2024.102432. Online ahead of print.ABSTRACTChronic pain conditions are unmet medical needs, since the available drugs, opioids, non-steroidal anti-inflammatory/analgesic drugs and adjuvant analgesics do not provide satisfactory therapeutic effect in a great proportion of patients. Therefore, there is an urgent need to find novel targets and novel therapeutic approaches that differ from classical pharmacological receptor antagonism. Most ion channels and receptors involved in pain sensation and processing such as Transient Receptor Potential ion channels, opioi...
Source: Current Opinion in Pharmacology - January 30, 2024 Category: Drugs & Pharmacology Authors: Andrea Kinga Nehr-Majoros Ágnes Király Zsuzsanna Helyes Éva Szőke Source Type: research
Editorial overview: Endocrine and metabolic diseases (2023)
Curr Opin Pharmacol. 2024 Jan 29;75:102436. doi: 10.1016/j.coph.2024.102436. Online ahead of print.NO ABSTRACTPMID:38290403 | DOI:10.1016/j.coph.2024.102436 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - January 30, 2024 Category: Drugs & Pharmacology Authors: Ivana Bjelobaba Stephanie Constantin Source Type: research
Lipid raft disruption as an opportunity for peripheral analgesia
Curr Opin Pharmacol. 2024 Jan 29;75:102432. doi: 10.1016/j.coph.2024.102432. Online ahead of print.ABSTRACTChronic pain conditions are unmet medical needs, since the available drugs, opioids, non-steroidal anti-inflammatory/analgesic drugs and adjuvant analgesics do not provide satisfactory therapeutic effect in a great proportion of patients. Therefore, there is an urgent need to find novel targets and novel therapeutic approaches that differ from classical pharmacological receptor antagonism. Most ion channels and receptors involved in pain sensation and processing such as Transient Receptor Potential ion channels, opioi...
Source: Current Opinion in Pharmacology - January 30, 2024 Category: Drugs & Pharmacology Authors: Andrea Kinga Nehr-Majoros Ágnes Király Zsuzsanna Helyes Éva Szőke Source Type: research
Editorial overview: New and revitalized old targets in metabolic disease
Curr Opin Pharmacol. 2024 Jan 25;75:102434. doi: 10.1016/j.coph.2024.102434. Online ahead of print.NO ABSTRACTPMID:38277941 | DOI:10.1016/j.coph.2024.102434 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - January 26, 2024 Category: Drugs & Pharmacology Authors: Jacob B Hansen Ivana Novak Source Type: research
Analgesic potential of voltage gated sodium channel modulators for the management of pain
Curr Opin Pharmacol. 2024 Jan 25;75:102433. doi: 10.1016/j.coph.2024.102433. Online ahead of print.ABSTRACTNeuronal electrochemical signals involve the flux of sodium ions through voltage-gated sodium channels (NaV) located in the neurolemma. Of the nine sodium channel subtypes, NaV-1.7, 1.8, and 1.9 are predominantly located on nociceptors, making them prime targets to control pain. This review highlights some of the latest discoveries targeting NaV channel activity, including: (1) charged local anaesthetic derivatives; (2) NaV channel toxins and associated small peptide blockers; (3) regulation of NaV channel accessory p...
Source: Current Opinion in Pharmacology - January 26, 2024 Category: Drugs & Pharmacology Authors: Jason J McDougall Melissa S O'Brien Source Type: research
Editorial overview: "Purinergic immune cell regulation reveals novel pharmacological targets"
Curr Opin Pharmacol. 2024 Jan 25;75:102435. doi: 10.1016/j.coph.2024.102435. Online ahead of print.NO ABSTRACTPMID:38277943 | DOI:10.1016/j.coph.2024.102435 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - January 26, 2024 Category: Drugs & Pharmacology Authors: Wolfgang Junger Carola Ledderose Source Type: research
Novel treatments for dry eye syndrome
Curr Opin Pharmacol. 2024 Jan 25;75:102431. doi: 10.1016/j.coph.2024.102431. Online ahead of print.ABSTRACTDry eye syndrome (DES) is a prevalent and multifactorial disease that leads to a self-perpetuating cycle of inflammation and damage to the ocular surface. This results in symptoms such as redness, burning, and blurred vision, which can negatively affect a patient's quality of life. While treatments are available to manage DES, they only temporarily relieve symptoms. Furthermore, long-term use of certain medications can cause harm to the ocular surface. Therefore, there is a need for safer and effective treatments for ...
Source: Current Opinion in Pharmacology - January 26, 2024 Category: Drugs & Pharmacology Authors: Esther Roucaute Marcela Huertas-Bello Alfonso L Sabater Source Type: research
Targeting ferroptosis in the maintenance of mitochondrial homeostasis in the realm of septic cardiomyopathy
Curr Opin Pharmacol. 2024 Feb;74:102430. doi: 10.1016/j.coph.2023.102430. Epub 2024 Jan 18.ABSTRACTSeptic cardiomyopathy is one of the predominant culprit factors contributing to the rising mortality in patients with severe sepsis. Among various mechanisms responsible for the etiology of septic heart anomalies, disruption of mitochondrial homeostasis has gained much recent attention, resulting in myocardial inflammation and even cell death. Ferroptosis is a novel category of regulated cell death (RCD) provoked by iron-dependent phospholipid peroxidation through iron-mediated phospholipid (PL) peroxidation, enroute to the r...
Source: Current Opinion in Pharmacology - January 18, 2024 Category: Drugs & Pharmacology Authors: Hua Ye Huantao Hu Xiaoliang Zhou Maolong Dong Jun Ren Source Type: research
AI-driven GPCR analysis, engineering, and targeting
This article investigates the role of recent advances in Artificial Intelligence (AI) to revolutionise the study of G protein-coupled receptors (GPCRs). AI has been applied to many areas of GPCR research, including the application of machine learning (ML) in GPCR classification, prediction of GPCR activation levels, modelling GPCR 3D structures and interactions, understanding G-protein selectivity, aiding elucidation of GPCRs structures, and drug design. Despite progress, challenges in predicting GPCR structures and addressing the complex nature of GPCRs remain, providing avenues for future research and development.PMID:38...
Source: Current Opinion in Pharmacology - January 14, 2024 Category: Drugs & Pharmacology Authors: Jo ão P L Velloso Aaron S Kovacs Douglas E V Pires David B Ascher Source Type: research
Integrating network pharmacology: The next-generation approach in ocular drug discovery
Curr Opin Pharmacol. 2024 Feb;74:102425. doi: 10.1016/j.coph.2023.102425. Epub 2024 Jan 5.ABSTRACTWith the spread of the "omics" sciences, the approaches of systems biology can be considered as new paradigms of pharmacological research for discovery of novel targets and/or treatments for complex multifactorial diseases. Data from omics sciences can be used for the design of biologic networks, that in turn can be quantitatively analyzed to identify new pharmacological targets. In this review, we will introduce the concept of network pharmacology, particularly the application of this innovative approach in the field of ocula...
Source: Current Opinion in Pharmacology - January 6, 2024 Category: Drugs & Pharmacology Authors: Francesca Lazzara Federica Conti Erika Giuffrida Chiara Maria Eandi Filippo Drago Chiara Bianca Maria Platania Claudio Bucolo Source Type: research
Integrating network pharmacology: The next-generation approach in ocular drug discovery
Curr Opin Pharmacol. 2024 Jan 5;74:102425. doi: 10.1016/j.coph.2023.102425. Online ahead of print.ABSTRACTWith the spread of the "omics" sciences, the approaches of systems biology can be considered as new paradigms of pharmacological research for discovery of novel targets and/or treatments for complex multifactorial diseases. Data from omics sciences can be used for the design of biologic networks, that in turn can be quantitatively analyzed to identify new pharmacological targets. In this review, we will introduce the concept of network pharmacology, particularly the application of this innovative approach in the field ...
Source: Current Opinion in Pharmacology - January 6, 2024 Category: Drugs & Pharmacology Authors: Francesca Lazzara Federica Conti Erika Giuffrida Chiara Maria Eandi Filippo Drago Chiara Bianca Maria Platania Claudio Bucolo Source Type: research
Integrating network pharmacology: The next-generation approach in ocular drug discovery
Curr Opin Pharmacol. 2024 Jan 5;74:102425. doi: 10.1016/j.coph.2023.102425. Online ahead of print.ABSTRACTWith the spread of the "omics" sciences, the approaches of systems biology can be considered as new paradigms of pharmacological research for discovery of novel targets and/or treatments for complex multifactorial diseases. Data from omics sciences can be used for the design of biologic networks, that in turn can be quantitatively analyzed to identify new pharmacological targets. In this review, we will introduce the concept of network pharmacology, particularly the application of this innovative approach in the field ...
Source: Current Opinion in Pharmacology - January 6, 2024 Category: Drugs & Pharmacology Authors: Francesca Lazzara Federica Conti Erika Giuffrida Chiara Maria Eandi Filippo Drago Chiara Bianca Maria Platania Claudio Bucolo Source Type: research
Human experience and efficacy of omidenepag isopropyl (Eybelis ®; Omlonti®): Discovery to approval of the novel non-prostaglandin EP2-receptor-selective agonist ocular hypotensive drug
Curr Opin Pharmacol. 2024 Jan 1;74:102426. doi: 10.1016/j.coph.2023.102426. Online ahead of print.ABSTRACTMore than 75 million people worldwide suffer from ocular hypertension (OHT)-associated retinal and optic nerve degenerative diseases that cause visual impairment and can lead to blindness. In an effort to find novel pharmaceutical therapeutics to combat OHT with reduced side-effect potential, several emerging drug candidates have advanced to human proof-of-concept in recent years. One such compound is a nonprostaglandin (non-PG) EP2-receptor-selective agonist (omidenepag isopropyl ester). Omidenepag (OMD; free acid for...
Source: Current Opinion in Pharmacology - January 3, 2024 Category: Drugs & Pharmacology Authors: Najam A Sharif Source Type: research
