Extracellular adenosine signaling in bone health and disease
Curr Opin Pharmacol. 2023 Apr 10;70:102378. doi: 10.1016/j.coph.2023.102378. Online ahead of print.ABSTRACTPurinergic signaling is a key molecular pathway in the maintenance of bone health and regeneration. P1 receptor signaling, which is activated by extracellular adenosine, has emerged as a key metabolic pathway that regulates bone tissue formation, function, and homeostasis. Extracellular adenosine is mainly produced by ectonucleotidases, and alterations in the function of these enzymes or compromised adenosine generation can result in bone disorders, such as osteoporosis and impaired fracture healing. This mini review ...
Source: Current Opinion in Pharmacology - April 12, 2023 Category: Drugs & Pharmacology Authors: Hunter Newman Shyni Varghese Source Type: research
Extracellular adenosine signaling in bone health and disease
Curr Opin Pharmacol. 2023 Apr 10;70:102378. doi: 10.1016/j.coph.2023.102378. Online ahead of print.ABSTRACTPurinergic signaling is a key molecular pathway in the maintenance of bone health and regeneration. P1 receptor signaling, which is activated by extracellular adenosine, has emerged as a key metabolic pathway that regulates bone tissue formation, function, and homeostasis. Extracellular adenosine is mainly produced by ectonucleotidases, and alterations in the function of these enzymes or compromised adenosine generation can result in bone disorders, such as osteoporosis and impaired fracture healing. This mini review ...
Source: Current Opinion in Pharmacology - April 12, 2023 Category: Drugs & Pharmacology Authors: Hunter Newman Shyni Varghese Source Type: research
Extracellular adenosine signaling in bone health and disease
Curr Opin Pharmacol. 2023 Apr 10;70:102378. doi: 10.1016/j.coph.2023.102378. Online ahead of print.ABSTRACTPurinergic signaling is a key molecular pathway in the maintenance of bone health and regeneration. P1 receptor signaling, which is activated by extracellular adenosine, has emerged as a key metabolic pathway that regulates bone tissue formation, function, and homeostasis. Extracellular adenosine is mainly produced by ectonucleotidases, and alterations in the function of these enzymes or compromised adenosine generation can result in bone disorders, such as osteoporosis and impaired fracture healing. This mini review ...
Source: Current Opinion in Pharmacology - April 12, 2023 Category: Drugs & Pharmacology Authors: Hunter Newman Shyni Varghese Source Type: research
Extracellular adenosine signaling in bone health and disease
Curr Opin Pharmacol. 2023 Apr 10;70:102378. doi: 10.1016/j.coph.2023.102378. Online ahead of print.ABSTRACTPurinergic signaling is a key molecular pathway in the maintenance of bone health and regeneration. P1 receptor signaling, which is activated by extracellular adenosine, has emerged as a key metabolic pathway that regulates bone tissue formation, function, and homeostasis. Extracellular adenosine is mainly produced by ectonucleotidases, and alterations in the function of these enzymes or compromised adenosine generation can result in bone disorders, such as osteoporosis and impaired fracture healing. This mini review ...
Source: Current Opinion in Pharmacology - April 12, 2023 Category: Drugs & Pharmacology Authors: Hunter Newman Shyni Varghese Source Type: research
Extracellular adenosine signaling in bone health and disease
Curr Opin Pharmacol. 2023 Apr 10;70:102378. doi: 10.1016/j.coph.2023.102378. Online ahead of print.ABSTRACTPurinergic signaling is a key molecular pathway in the maintenance of bone health and regeneration. P1 receptor signaling, which is activated by extracellular adenosine, has emerged as a key metabolic pathway that regulates bone tissue formation, function, and homeostasis. Extracellular adenosine is mainly produced by ectonucleotidases, and alterations in the function of these enzymes or compromised adenosine generation can result in bone disorders, such as osteoporosis and impaired fracture healing. This mini review ...
Source: Current Opinion in Pharmacology - April 12, 2023 Category: Drugs & Pharmacology Authors: Hunter Newman Shyni Varghese Source Type: research
