Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
