Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors
Curr Opin Pharmacol. 2023 Jun 10;71:102382. doi: 10.1016/j.coph.2023.102382. Online ahead of print.ABSTRACTGonadotropin-releasing hormone (GnRH) neurons are the final output pathway for the brain control of reproduction. The activity of this neuronal population, mainly located at the preoptic area of the hypothalamus, is controlled by a plethora of metabolic signals. However, it has been documented that most of these signal impact on GnRH neurons through indirect neuronal circuits, Kiss1, proopiomelanocortin, and neuropeptide Y/agouti-related peptide neurons being some of the most prominent mediators. In this context, comp...
Source: Current Opinion in Pharmacology - June 12, 2023 Category: Drugs & Pharmacology Authors: Miguel Ruiz-Cruz Carmen Torres-Granados Manuel Tena-Sempere Juan Roa Source Type: research
Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors
Curr Opin Pharmacol. 2023 Jun 10;71:102382. doi: 10.1016/j.coph.2023.102382. Online ahead of print.ABSTRACTGonadotropin-releasing hormone (GnRH) neurons are the final output pathway for the brain control of reproduction. The activity of this neuronal population, mainly located at the preoptic area of the hypothalamus, is controlled by a plethora of metabolic signals. However, it has been documented that most of these signal impact on GnRH neurons through indirect neuronal circuits, Kiss1, proopiomelanocortin, and neuropeptide Y/agouti-related peptide neurons being some of the most prominent mediators. In this context, comp...
Source: Current Opinion in Pharmacology - June 12, 2023 Category: Drugs & Pharmacology Authors: Miguel Ruiz-Cruz Carmen Torres-Granados Manuel Tena-Sempere Juan Roa Source Type: research
Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors
Curr Opin Pharmacol. 2023 Jun 10;71:102382. doi: 10.1016/j.coph.2023.102382. Online ahead of print.ABSTRACTGonadotropin-releasing hormone (GnRH) neurons are the final output pathway for the brain control of reproduction. The activity of this neuronal population, mainly located at the preoptic area of the hypothalamus, is controlled by a plethora of metabolic signals. However, it has been documented that most of these signal impact on GnRH neurons through indirect neuronal circuits, Kiss1, proopiomelanocortin, and neuropeptide Y/agouti-related peptide neurons being some of the most prominent mediators. In this context, comp...
Source: Current Opinion in Pharmacology - June 12, 2023 Category: Drugs & Pharmacology Authors: Miguel Ruiz-Cruz Carmen Torres-Granados Manuel Tena-Sempere Juan Roa Source Type: research
Corrigendum to "Antihypertensive effect of soybean bioactive peptides: A review" [Curr Opin Pharmacol (62) (2022) 74-81]
Curr Opin Pharmacol. 2023 Jun 3;71:102383. doi: 10.1016/j.coph.2023.102383. Online ahead of print.NO ABSTRACTPMID:37276767 | DOI:10.1016/j.coph.2023.102383 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 5, 2023 Category: Drugs & Pharmacology Authors: Tingna Li Xiaorui Zhang Yuanyuan Ren Yijia Zeng Qinwan Huang Chao Wang Source Type: research
Corrigendum to "Antihypertensive effect of soybean bioactive peptides: A review" [Curr Opin Pharmacol (62) (2022) 74-81]
Curr Opin Pharmacol. 2023 Jun 3;71:102383. doi: 10.1016/j.coph.2023.102383. Online ahead of print.NO ABSTRACTPMID:37276767 | DOI:10.1016/j.coph.2023.102383 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 5, 2023 Category: Drugs & Pharmacology Authors: Tingna Li Xiaorui Zhang Yuanyuan Ren Yijia Zeng Qinwan Huang Chao Wang Source Type: research
Corrigendum to "Antihypertensive effect of soybean bioactive peptides: A review" [Curr Opin Pharmacol (62) (2022) 74-81]
Curr Opin Pharmacol. 2023 Jun 3;71:102383. doi: 10.1016/j.coph.2023.102383. Online ahead of print.NO ABSTRACTPMID:37276767 | DOI:10.1016/j.coph.2023.102383 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 5, 2023 Category: Drugs & Pharmacology Authors: Tingna Li Xiaorui Zhang Yuanyuan Ren Yijia Zeng Qinwan Huang Chao Wang Source Type: research
Corrigendum to "Antihypertensive effect of soybean bioactive peptides: A review" [Curr Opin Pharmacol (62) (2022) 74-81]
Curr Opin Pharmacol. 2023 Jun 3;71:102383. doi: 10.1016/j.coph.2023.102383. Online ahead of print.NO ABSTRACTPMID:37276767 | DOI:10.1016/j.coph.2023.102383 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 5, 2023 Category: Drugs & Pharmacology Authors: Tingna Li Xiaorui Zhang Yuanyuan Ren Yijia Zeng Qinwan Huang Chao Wang Source Type: research
Corrigendum to "Antihypertensive effect of soybean bioactive peptides: A review" [Curr Opin Pharmacol (62) (2022) 74-81]
Curr Opin Pharmacol. 2023 Jun 3;71:102383. doi: 10.1016/j.coph.2023.102383. Online ahead of print.NO ABSTRACTPMID:37276767 | DOI:10.1016/j.coph.2023.102383 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 5, 2023 Category: Drugs & Pharmacology Authors: Tingna Li Xiaorui Zhang Yuanyuan Ren Yijia Zeng Qinwan Huang Chao Wang Source Type: research
Corrigendum to "Antihypertensive effect of soybean bioactive peptides: A review" [Curr Opin Pharmacol (62) (2022) 74-81]
Curr Opin Pharmacol. 2023 Jun 3;71:102383. doi: 10.1016/j.coph.2023.102383. Online ahead of print.NO ABSTRACTPMID:37276767 | DOI:10.1016/j.coph.2023.102383 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 5, 2023 Category: Drugs & Pharmacology Authors: Tingna Li Xiaorui Zhang Yuanyuan Ren Yijia Zeng Qinwan Huang Chao Wang Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 Jun;70:102380. doi: 10.1016/j.coph.2023.102380. Epub 2023 May 5.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the ALT mec...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 Jun;70:102380. doi: 10.1016/j.coph.2023.102380. Epub 2023 May 5.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the ALT mec...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Curr Opin Pharmacol. 2023 May 5;70:102380. doi: 10.1016/j.coph.2023.102380. Online ahead of print.ABSTRACTThe alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive cells relies on a baseline level of DNA replication stress to initiate elongation events. This results in an elevated level of DNA damage and presents a possible vulnerability to be exploited in the development of ALT-targeted cancer therapies. Currently, there are no treatment options that target the...
Source: Current Opinion in Pharmacology - May 7, 2023 Category: Drugs & Pharmacology Authors: Lisa M Carson Rachel L Flynn Source Type: research
